11-Hydroxy-Delta-8-THC

11-Hydroxy-Delta-8-THC

Identifiers
IUPAC name (6aR,10aR)-9-(hydroxymethyl)-6,6-dimethyl-3-pentyl-6a,7,10,10a-tetrahydrobenzo[c]chromen-1-ol
CAS Number	28646-40-4 N[EPA]
PubChem CID	185651
ChemSpider	161395
UNII	GM4TR07BPX
Chemical and physical data
Formula	C21H30O3
Molar mass	330.468 g·mol−1
3D model (JSmol)	Interactive image
SMILES CCCCCC1=CC(=C2[C@@H]3CC(=CC[C@H]3C(OC2=C1)(C)C)CO)O
InChI InChI=1S/C21H30O3/c1-4-5-6-7-14-11-18(23)20-16-10-15(13-22)8-9-17(16)21(2,3)24-19(20)12-14/h8,11-12,16-17,22-23H,4-7,9-10,13H2,1-3H3/t16-,17-/m1/s1 Key:LOUSQMWLMDHRIK-IAGOWNOFSA-N

11-Hydroxy-Delta-8-tetrahydrocannabinol (11-OH-Δ⁸-THC, alternatively numbered as 7-OH-Δ⁶-THC) is an active metabolite of Δ⁸-THC, a psychoactive cannabinoid found in small amounts in cannabis. It is an isomer of 11-OH-Δ⁹-THC, and is produced via the same metabolic pathway. It was the first cannabinoid metabolite discovered in 1970.^[1]

It retains psychoactive effects in animal studies with higher potency than Δ⁸-THC but lower potency than 11-OH-Δ⁹-THC. With widespread legal use of semi-synthetic Δ⁸-THC in certain jurisdictions where Δ⁹-THC remains illegal, 11-OH-Δ⁸-THC is now an important metabolite for distinguishing between use of legal Δ⁸-THC and illegal Δ⁹-THC.^{[2][3][4][5][6]}

See also

• 11-Hydroxy-THC
• 11-Hydroxyhexahydrocannabinol
• 3'-Hydroxy-THC
• 7-Hydroxycannabidiol
• 8,11-Dihydroxytetrahydrocannabinol
• 9-OH-HHC
• 11-OH-HHC
• 11-OH-CBN
• 11-Nor-9-carboxy-THC
• Delta-6-Cannabidiol
• Delta-10-Tetrahydrocannabinol
• HU-210
• Delta-11-Tetrahydrocannabinol

References

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