18-Methylaminocoronaridine
Chemical compound
- 44325016
- 24721797 Y
- Interactive image
- c4cccc1c4[nH]c3c1CCN2CC(C5)CC3(C(=O)OC)C2C5CCNC
InChI
- InChI=1S/C22H29N3O2/c1-23-9-7-15-11-14-12-22(21(26)27-2)19-17(8-10-25(13-14)20(15)22)16-5-3-4-6-18(16)24-19/h3-6,14-15,20,23-24H,7-13H2,1-2H3/t14-,15+,20+,22-/m1/s1 Y
- Key:YKMOJVPLIUXEIP-SVBQBFEESA-N Y
(−)-18-Methylaminocoronaridine (18-MAC) is a second generation synthetic derivative of ibogaine developed by the research team led by the pharmacologist Stanley D. Glick from the Albany Medical College and the chemist Martin E. Kuehne from the University of Vermont.[1][2]
See also
- 2-Methoxyethyl-18-methoxycoronaridinate
- 18-Methoxycoronaridine
- Coronaridine
- Ibogaine
- Noribogaine
- Voacangine
References
- ^ Kuehne ME, He L, Jokiel PA, Pace CJ, Fleck MW, Maisonneuve IM, et al. (June 2003). "Synthesis and biological evaluation of 18-methoxycoronaridine congeners. Potential antiaddiction agents". Journal of Medicinal Chemistry. 46 (13): 2716–30. doi:10.1021/jm020562o. PMID 12801235.
- ^ Pace CJ, Glick SD, Maisonneuve IM, He LW, Jokiel PA, Kuehne ME, Fleck MW (May 2004). "Novel iboga alkaloid congeners block nicotinic receptors and reduce drug self-administration". European Journal of Pharmacology. 492 (2–3): 159–67. doi:10.1016/j.ejphar.2004.03.062. PMID 15178360.
- v
- t
- e
Nicotinic acetylcholine receptor modulators
(and prodrugs)
- See also
- Receptor/signaling modulators
- Muscarinic acetylcholine receptor modulators
- Acetylcholine metabolism/transport modulators