6-Nitroquipazine
Chemical compound
- none
- In general: uncontrolled
- 6-nitro-2-piperazin-1-yl-quinoline
- 77372-73-7 N
- 5012
- 4837 Y
- 28M0X094BH
- ChEMBL41140 Y
- DTXSID7044001
- Interactive image
- [O-][N+](=O)c3cc1c(nc(cc1)N2CCNCC2)cc3
InChI
- InChI=1S/C13H14N4O2/c18-17(19)11-2-3-12-10(9-11)1-4-13(15-12)16-7-5-14-6-8-16/h1-4,9,14H,5-8H2 Y
- Key:GGDBEAVVGFNWIA-UHFFFAOYSA-N Y
6-Nitroquipazine (developmental code name DU-24,565) is a potent and selective serotonin reuptake inhibitor used in scientific research.[1][2]
6-Nitroquipazine has been found to inhibit melanogenesis in-vitro,[3] suggesting that it can be used for skin whitening.
See also
- Quipazine
References
- ^ Vaatstra WJ, Deiman-Van Aalst WM, Eigeman L (March 1981). "Du 24565, a quipazine derivative, a potent selective serotonin uptake inhibitor". European Journal of Pharmacology. 70 (2): 195–202. doi:10.1016/0014-2999(81)90214-4. PMID 6973481.
- ^ Classen K, Göthert M, Schlicker E (June 1984). "Effects of DU 24565 (6-nitroquipazine) on serotoninergic and noradrenergic neurones of the rat brain and comparison with the effects of quipazine". Naunyn-Schmiedeberg's Archives of Pharmacology. 326 (3): 198–202. doi:10.1007/bf00505318. PMID 6206407. S2CID 20858707.
- ^ McEwan M, Parsons PG (July 1987). "Inhibition of melanization in human melanoma cells by a serotonin uptake inhibitor". The Journal of Investigative Dermatology. 89 (1): 82–86. doi:10.1111/1523-1747.ep12580425. PMID 3110297. No-cost access but non-free license.
- v
- t
- e
(DRIsTooltip Dopamine reuptake inhibitors)
(NRIsTooltip Norepinephrine reuptake inhibitors)
(SRIsTooltip Serotonin reuptake inhibitors)
- Amiodarone
- Amphetamines (e.g., amphetamine, methamphetamine, MDMA)
- APP
- AZIK
- Bietaserpine
- Deserpidine
- Deutetrabenazine
- Dihydrotetrabenazine
- Efavirenz
- GBR-12935
- GZ-793A
- Ibogaine
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- Methoxytetrabenazine
- Reserpine
- Rose bengal
- Tetrabenazine
- Valbenazine
- Vanoxerine (GBR-12909)
- DAT enhancers: Luteolin
- DAT modulators: Agonist-like: SoRI-9804
- SoRI-20040; Antagonist-like: SoRI-20041
See also: Receptor/signaling modulators • Monoamine releasing agents • Adrenergics • Dopaminergics • Serotonergics • Monoamine metabolism modulators • Monoamine neurotoxins