7α-Hydroxycholesterol
Names | |
---|---|
IUPAC name Cholest-5-ene-3β,7α-diol | |
Systematic IUPAC name (1R,3aS,3bS,4S,7S,9aR,9bS,11aR)-9a,11a-Dimethyl-1-[(2R)-6-methylheptan-2-yl]-2,3,3a,3b,4,6,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-cyclopenta[a]phenanthrene-4,7-diol | |
Identifiers | |
CAS Number |
|
3D model (JSmol) |
|
ChEBI |
|
ChemSpider |
|
IUPHAR/BPS |
|
MeSH | 7+alpha-hydroxycholesterol |
PubChem CID |
|
UNII |
|
CompTox Dashboard (EPA) |
|
InChI
| |
| |
Properties | |
Chemical formula | C27H46O2 |
Molar mass | 402.653 g/mol |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Y verify (what is YN ?) Infobox references |
Chemical compound
7α-Hydroxycholesterol is a precursor of bile acids, created by cholesterol 7α-hydroxylase (CYP7A1). Its formation is the rate-determining step in bile acid synthesis.[1]
References
- ^ Chiang JY, Ferrell JM (March 2020). "Bile acid receptors FXR and TGR5 signaling in fatty liver diseases and therapy". American Journal of Physiology. Gastrointestinal and Liver Physiology. 318 (3): G554–G573. doi:10.1152/ajpgi.00223.2019. PMC 7099488. PMID 31984784.
- v
- t
- e
Cholesterol and steroid metabolic intermediates
to HMG-CoA | |
---|---|
Ketone bodies | |
to DMAPP | |
Geranyl- | |
Carotenoid |
- Lanosterol
- 14-demethyllanosterol
- 4alpha-Methylzymosterol
- Zymosterone
- Zymosterol
- Zymosterol
- Zymostenol
- Lathosterol
- 7-Dehydrocholesterol
- Cholesterol
- Zymosterol
- Cholesta-7,24-dien-3-ol
- 7-Dehydrodesmosterol
- Desmosterol
- Cholesterol
to Steroid hormones
- 22R-Hydroxycholesterol
- 20α,22R-Dihydroxycholesterol
- See here instead.
To Sitosterol |
|
---|---|
To Ergocalciferol |
|
This article about a steroid is a stub. You can help Wikipedia by expanding it. |
- v
- t
- e