ABCG4

Protein-coding gene in the species Homo sapiens
ABCG4
Identifiers
AliasesABCG4, WHITE2, ATP binding cassette subfamily G member 4
External IDsOMIM: 607784 MGI: 1890594 HomoloGene: 75179 GeneCards: ABCG4
Gene location (Human)
Chromosome 11 (human)
Chr.Chromosome 11 (human)[1]
Chromosome 11 (human)
Genomic location for ABCG4
Genomic location for ABCG4
Band11q23.3Start119,149,052 bp[1]
End119,162,653 bp[1]
Gene location (Mouse)
Chromosome 9 (mouse)
Chr.Chromosome 9 (mouse)[2]
Chromosome 9 (mouse)
Genomic location for ABCG4
Genomic location for ABCG4
Band9|9 A5.2Start44,184,485 bp[2]
End44,199,912 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • prefrontal cortex

  • oocyte

  • secondary oocyte

  • dorsolateral prefrontal cortex

  • Brodmann area 9

  • postcentral gyrus

  • Brodmann area 46

  • superior frontal gyrus

  • cerebellar vermis

  • entorhinal cortex
Top expressed in
  • superior frontal gyrus

  • cerebellar cortex

  • superior colliculus

  • dorsal tegmental nucleus

  • habenula

  • subiculum

  • pontine nuclei

  • inferior colliculus

  • lateral geniculate nucleus

  • medial dorsal nucleus
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • nucleotide binding
  • ATPase activity
  • protein binding
  • ATP binding
  • cholesterol transfer activity
  • protein homodimerization activity
  • ABC-type sterol transporter activity
  • protein heterodimerization activity
  • ATPase-coupled transmembrane transporter activity
Cellular component
  • integral component of membrane
  • plasma membrane
  • membrane
Biological process
  • transmembrane transport
  • cholesterol efflux
  • cellular response to leukemia inhibitory factor
  • cholesterol transport
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

64137

192663

Ensembl

ENSG00000172350

ENSMUSG00000032131

UniProt

Q9H172

Q91WA9

RefSeq (mRNA)

NM_001142505
NM_022169
NM_001348191
NM_001348192

NM_138955

RefSeq (protein)

NP_001135977
NP_071452
NP_001335120
NP_001335121

NP_620405

Location (UCSC)Chr 11: 119.15 – 119.16 MbChr 9: 44.18 – 44.2 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

ATP-binding cassette sub-family G member 4 is a protein that in humans is encoded by the ABCG4 gene.[5][6]

The protein encoded by this gene is included in the ATP-binding cassette transporter (ABC protein) superfamily. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily and is expressed predominantly in liver tissue. The function has not yet been determined but may involve cholesterol transport. Alternate splice variants have been described but their full length sequences have not been determined.[6]

ABCG4 has demonstrated, in vitro, to participate in the efflux of desmosterol and amyloid-β peptide (Aβ). It is highly expressed in the brain, but its localization and function at the blood-brain barrier (BBB) level remain unknown.[7]

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000172350 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000032131 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Dean M, Rzhetsky A, Allikmets R (Jul 2001). "The human ATP-binding cassette (ABC) transporter superfamily". Genome Res. 11 (7): 1156–66. doi:10.1101/gr.184901. PMID 11435397. S2CID 9528197.
  6. ^ a b "Entrez Gene: ABCG4 ATP-binding cassette, sub-family G (WHITE), member 4".
  7. ^ Dodacki, Agnès (2017). "Expression and function of Abcg4 in the mouse blood-brain barrier: role in restricting the brain entry of amyloid-β peptide". Scientific Reports. 7 (1). Springer Nature: 13393. Bibcode:2017NatSR...713393D. doi:10.1038/s41598-017-13750-0. PMC 5645361. PMID 29042617.

Further reading

  • Engel T, Lorkowski S, Lueken A, et al. (2001). "The human ABCG4 gene is regulated by oxysterols and retinoids in monocyte-derived macrophages". Biochem. Biophys. Res. Commun. 288 (2): 483–8. doi:10.1006/bbrc.2001.5756. PMID 11606068.
  • Annilo T, Tammur J, Hutchinson A, et al. (2002). "Human and mouse orthologs of a new ATP-binding cassette gene, ABCG4". Cytogenet. Cell Genet. 94 (3–4): 196–201. doi:10.1159/000048816. PMID 11856881. S2CID 19897612.
  • Yoshikawa M, Yabuuchi H, Kuroiwa A, et al. (2002). "Molecular and cytogenetic characterization of the mouse ATP-binding cassette transporter Abcg4". Gene. 293 (1–2): 67–75. doi:10.1016/S0378-1119(02)00719-9. PMID 12137944.
  • Oldfield S, Lowry C, Ruddick J, Lightman S (2002). "ABCG4: a novel human white family ABC-transporter expressed in the brain and eye". Biochim. Biophys. Acta. 1591 (1–3): 175–9. doi:10.1016/S0167-4889(02)00269-0. PMID 12183068.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Cserepes J, Szentpétery Z, Seres L, et al. (2004). "Functional expression and characterization of the human ABCG1 and ABCG4 proteins: indications for heterodimerization". Biochem. Biophys. Res. Commun. 320 (3): 860–7. doi:10.1016/j.bbrc.2004.06.037. PMID 15240127.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Engel T, Bode G, Lueken A, et al. (2006). "Expression and functional characterization of ABCG1 splice variant ABCG1(666)". FEBS Lett. 580 (18): 4551–9. doi:10.1016/j.febslet.2006.07.006. PMID 16870176. S2CID 22947257.
  • Vaughan AM, Oram JF (2007). "ABCA1 and ABCG1 or ABCG4 act sequentially to remove cellular cholesterol and generate cholesterol-rich HDL". J. Lipid Res. 47 (11): 2433–43. doi:10.1194/jlr.M600218-JLR200. PMID 16902247. S2CID 15872767.

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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