ACSS3

Protein-coding gene in humans
ACSS3
Identifiers
AliasesACSS3, acyl-CoA synthetase short-chain family member 3, acyl-CoA synthetase short chain family member 3
External IDsOMIM: 614356; MGI: 2685720; HomoloGene: 11587; GeneCards: ACSS3; OMA:ACSS3 - orthologs
Gene location (Human)
Chromosome 12 (human)
Chr.Chromosome 12 (human)[1]
Chromosome 12 (human)
Genomic location for ACSS3
Genomic location for ACSS3
Band12q21.31Start80,936,414 bp[1]
End81,261,210 bp[1]
Gene location (Mouse)
Chromosome 10 (mouse)
Chr.Chromosome 10 (mouse)[2]
Chromosome 10 (mouse)
Genomic location for ACSS3
Genomic location for ACSS3
Band10|10 D1Start106,769,378 bp[2]
End106,959,529 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • germinal epithelium

  • parotid gland

  • liver

  • Achilles tendon

  • corpus epididymis

  • left adrenal gland

  • right lobe of liver

  • caput epididymis

  • right adrenal cortex

  • left adrenal cortex
Top expressed in
  • white adipose tissue

  • otolith organ

  • utricle

  • brown adipose tissue

  • intercostal muscle

  • gastrula

  • mammary gland

  • subcutaneous adipose tissue

  • Epithelium of choroid plexus

  • olfactory epithelium
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • nucleotide binding
  • ligase activity
  • catalytic activity
  • ATP binding
  • acetate-CoA ligase activity
Cellular component
  • mitochondrion
  • mitochondrial matrix
Biological process
  • metabolism
  • ketone body biosynthetic process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

79611

380660

Ensembl

ENSG00000111058

ENSMUSG00000035948

UniProt

Q9H6R3

Q14DH7

RefSeq (mRNA)

NM_024560
NM_001330242
NM_001330243

NM_001142804
NM_198636

RefSeq (protein)

NP_001317171
NP_001317172
NP_078836

NP_001136276
NP_941038

Location (UCSC)Chr 12: 80.94 – 81.26 MbChr 10: 106.77 – 106.96 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Acyl-CoA synthetase short-chain family member 3 is a protein that in humans is encoded by the ACSS3 gene.[5]

Function

ACSS3 is part of a family known as Acyl-coenzyme A synthetases (ACSs), which catalyze the initial reaction in fatty acid metabolism. This reaction activates fatty acids via thioesterification to CoA, thereby allowing their participation in both anabolic and catabolic pathways. The existence of many ACSs suggests that each plays a unique role, directing the acyl-CoA product to a specific metabolic fate. Knowing the full complement of ACS genes in the human genome will facilitate future studies to characterize their specific biological functions.[6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000111058 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000035948 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: Acyl-CoA synthetase short-chain family member 3".
  6. ^ Watkins PA, Maiguel D, Jia Z, Pevsner J (Dec 2007). "Evidence for 26 distinct acyl-coenzyme A synthetase genes in the human genome". Journal of Lipid Research. 48 (12): 2736–50. doi:10.1194/jlr.M700378-JLR200. PMID 17762044.

Further reading

  • Hunter AM, Leuchter AF, Power RA, Muthén B, McGrath PJ, Lewis CM, Cook IA, Garriock HA, McGuffin P, Uher R, Hamilton SP (Sep 2013). "A genome-wide association study of a sustained pattern of antidepressant response". Journal of Psychiatric Research. 47 (9): 1157–65. doi:10.1016/j.jpsychires.2013.05.002. PMC 3710535. PMID 23726668.
  • Watkins PA, Maiguel D, Jia Z, Pevsner J (Dec 2007). "Evidence for 26 distinct acyl-coenzyme A synthetase genes in the human genome". Journal of Lipid Research. 48 (12): 2736–50. doi:10.1194/jlr.M700378-JLR200. PMID 17762044.
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