AKIRIN2

Protein-coding gene in the species Homo sapiens
AKIRIN2
Identifiers
AliasesAKIRIN2, C6orf166, FBI1, dJ486L4.2, akirin 2
External IDsOMIM: 615165 MGI: 1889364 HomoloGene: 9988 GeneCards: AKIRIN2
Gene location (Human)
Chromosome 6 (human)
Chr.Chromosome 6 (human)[1]
Chromosome 6 (human)
Genomic location for AKIRIN2
Genomic location for AKIRIN2
Band6q15Start87,674,860 bp[1]
End87,702,233 bp[1]
Gene location (Mouse)
Chromosome 4 (mouse)
Chr.Chromosome 4 (mouse)[2]
Chromosome 4 (mouse)
Genomic location for AKIRIN2
Genomic location for AKIRIN2
Band4|4 A5Start34,550,937 bp[2]
End34,566,908 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • oocyte

  • monocyte

  • secondary oocyte

  • ganglionic eminence

  • gastrocnemius muscle

  • spleen

  • tibialis anterior muscle

  • appendix

  • lymph node

  • blood
Top expressed in
  • oocyte

  • secondary oocyte

  • medial ganglionic eminence

  • seminiferous tubule

  • abdominal wall

  • primitive streak

  • entorhinal cortex

  • superior surface of tongue

  • endocardial cushion

  • extraocular muscle
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • enzyme binding
  • protein binding
Cellular component
  • transcription repressor complex
  • nucleus
  • nucleoplasm
Biological process
  • multicellular organism development
  • positive regulation of endopeptidase activity
  • response to lipopolysaccharide
  • innate immune response
  • negative regulation of transcription, DNA-templated
  • regulation of transcription, DNA-templated
  • negative regulation of transcription by RNA polymerase II
  • negative regulation of gene expression
  • transcription, DNA-templated
  • positive regulation of cell population proliferation
  • positive regulation of interleukin-6 production
  • positive regulation of transcription by RNA polymerase II
  • immune system process
  • embryo development ending in birth or egg hatching
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

55122

433693

Ensembl

ENSG00000135334

ENSMUSG00000028291

UniProt

Q53H80

B1AXD8

RefSeq (mRNA)

NM_018064

NM_001007589
NM_026019

RefSeq (protein)

NP_060534

NP_001007590

Location (UCSC)Chr 6: 87.67 – 87.7 MbChr 4: 34.55 – 34.57 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Akirin-2 is a protein that in humans is encoded by the AKIRIN2 gene.[5]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000135334 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028291 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: C6orf166 chromosome 6 open reading frame 166".

External links

Further reading

  • Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (Nov 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
  • Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (Oct 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Maruyama K, Sugano S (Jan 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.


  • v
  • t
  • e