APBA3

Protein-coding gene in the species Homo sapiens
APBA3
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

2YT7, 2YT8

Identifiers
AliasesAPBA3, MGC:15815, X11L2, mint3, amyloid beta precursor protein binding family A member 3
External IDsOMIM: 604262 MGI: 1888527 HomoloGene: 3591 GeneCards: APBA3
Gene location (Human)
Chromosome 19 (human)
Chr.Chromosome 19 (human)[1]
Chromosome 19 (human)
Genomic location for APBA3
Genomic location for APBA3
Band19p13.3Start3,750,772 bp[1]
End3,761,692 bp[1]
Gene location (Mouse)
Chromosome 10 (mouse)
Chr.Chromosome 10 (mouse)[2]
Chromosome 10 (mouse)
Genomic location for APBA3
Genomic location for APBA3
Band10|10 C1Start81,102,794 bp[2]
End81,109,080 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • pancreatic ductal cell

  • blood

  • spleen

  • lymph node

  • gastrocnemius muscle

  • right lobe of thyroid gland

  • pituitary gland

  • canal of the cervix

  • right coronary artery

  • left lobe of thyroid gland
Top expressed in
  • skeletal muscle tissue

  • adrenal gland

  • spermatocyte

  • yolk sac

  • quadriceps femoris muscle

  • proximal tubule

  • esophagus

  • white adipose tissue

  • kidney

  • lip
More reference expression data
BioGPS


More reference expression data
Gene ontology
Molecular function
  • enzyme binding
  • enzyme inhibitor activity
  • amyloid-beta binding
  • protein binding
Cellular component
  • cytoplasm
  • perinuclear region of cytoplasm
  • plasma membrane
  • dendritic spine
  • synapse
Biological process
  • protein transport
  • regulation of catalytic activity
  • negative regulation of catalytic activity
  • in utero embryonic development
  • chemical synaptic transmission
  • regulation of gene expression
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

9546

57267

Ensembl

ENSG00000011132

ENSMUSG00000004931

UniProt

O96018

O88888

RefSeq (mRNA)

NM_004886

NM_018758

RefSeq (protein)

NP_004877

NP_061228

Location (UCSC)Chr 19: 3.75 – 3.76 MbChr 10: 81.1 – 81.11 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Amyloid beta A4 precursor protein-binding family A member 3 is a protein that in humans is encoded by the APBA3 gene.[5][6]

Function

The protein encoded by this gene is a member of the X11 protein family. It is an adapter protein that interacts with the Alzheimer's disease amyloid precursor protein. This gene product is believed to be involved in signal transduction processes. This gene is a candidate gene for Alzheimer's disease.[6]

Interactions

APBA3 has been shown to interact with Amyloid precursor protein.[5][7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000011132 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000004931 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b Tanahashi H, Tabira T (Apr 1999). "X11L2, a new member of the X11 protein family, interacts with Alzheimer's beta-amyloid precursor protein". Biochem Biophys Res Commun. 255 (3): 663–7. doi:10.1006/bbrc.1999.0265. PMID 10049767.
  6. ^ a b "Entrez Gene: APBA3 amyloid beta (A4) precursor protein-binding, family A, member 3 (X11-like 2)".
  7. ^ Biederer T, Cao X, Südhof TC, Liu X (Sep 2002). "Regulation of APP-dependent transcription complexes by Mint/X11s: differential functions of Mint isoforms". J. Neurosci. 22 (17): 7340–51. doi:10.1523/JNEUROSCI.22-17-07340.2002. PMC 6757996. PMID 12196555.

External links

Further reading

  • Kuriyan J, Cowburn D (1997). "Modular peptide recognition domains in eukaryotic signaling". Annual Review of Biophysics and Biomolecular Structure. 26: 259–88. doi:10.1146/annurev.biophys.26.1.259. PMID 9241420.
  • Morishima-Kawashima M, Ihara Y (2002). "[Recent advances in Alzheimer's disease]". Seikagaku. 73 (11): 1297–307. PMID 11831025.
  • Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
  • Okamoto M, Südhof TC (1999). "Mint 3: a ubiquitous mint isoform that does not bind to munc18-1 or -2". Eur. J. Cell Biol. 77 (3): 161–5. doi:10.1016/s0171-9335(98)80103-9. PMID 9860131.
  • Tanahashi H, Tabira T (1999). "Genomic organization of the human X11L2 gene (APBA3), a third member of the X11 protein family interacting with Alzheimer's beta-amyloid precursor protein". NeuroReport. 10 (12): 2575–8. doi:10.1097/00001756-199908200-00025. PMID 10574372.
  • Okamoto M, Nakajima Y, Matsuyama T, Sugita M (2001). "Amyloid precursor protein associates independently and collaboratively with PTB and PDZ domains of mint on vesicles and at cell membrane". Neuroscience. 104 (3): 653–65. doi:10.1016/S0306-4522(01)00124-5. PMID 11440799. S2CID 39280897.
  • Wang P, Wang X, Pei D (2004). "Mint-3 regulates the retrieval of the internalized membrane-type matrix metalloproteinase, MT5-MMP, to the plasma membrane by binding to its carboxyl end motif EWV". J. Biol. Chem. 279 (19): 20461–70. doi:10.1074/jbc.M400264200. PMID 14990567.
  • Malmberg EK, Andersson CX, Gentzsch M, Chen JH, Mengos A, Cui L, Hansson GC, Riordan JR (2005). "Bcr (breakpoint cluster region) protein binds to PDZ-domains of scaffold protein PDZK1 and vesicle coat protein Mint3". J. Cell Sci. 117 (Pt 23): 5535–41. doi:10.1242/jcs.01472. PMID 15494376.

External links

  • PDBe-KB provides an overview of all the structure information available in the PDB for Human Amyloid-beta A4 precursor protein-binding family A member 3 (APBA3)
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