ARID2

ARID2
Identifiers
Aliases	ARID2, BAF200, p200, AT-rich interaction domain 2, CSS6, SMARCF3
External IDs	OMIM: 609539 MGI: 1924294 HomoloGene: 14601 GeneCards: ARID2
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q12 Start 45,729,706 bp[1] End 45,908,040 bp[1]
Gene location (Mouse) Chr. Chromosome 15 (mouse)[2] Band 15|15 F1 Start 96,185,399 bp[2] End 96,302,873 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sperm pancreatic ductal cell secondary oocyte bone marrow cells thymus ganglionic eminence trabecular bone Achilles tendon nipple tibialis anterior muscle Top expressed in hair follicle primitive streak ciliary body internal carotid artery external carotid artery hand vas deferens iris Paneth cell cumulus cell More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding protein binding metal ion binding nucleic acid binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component plasma membrane nucleus nucleoplasm Biological process nucleosome disassembly regulation of transcription, DNA-templated transcription, DNA-templated negative regulation of cell migration negative regulation of cell population proliferation heart morphogenesis homeostatic process embryonic organ development cardiac muscle cell proliferation coronary artery morphogenesis chromatin organization regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 196528 77044 Ensembl ENSG00000189079 ENSMUSG00000033237 UniProt Q68CP9 E9Q7E2 RefSeq (mRNA) NM_152641 NM_001347839 NM_175251 RefSeq (protein) NP_001334768 NP_689854 NP_780460 Location (UCSC) Chr 12: 45.73 – 45.91 Mb Chr 15: 96.19 – 96.3 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

AT-rich interactive domain-containing protein 2 (ARID2) is a protein that in humans is encoded by the ARID2 gene.^[5]

Function

ARID2 is a subunit of the PBAF chromatin-remodeling complex, which facilitates ligand-dependent transcriptional activation by nuclear receptors.^[5]

Structure

The ARID2 protein contains two conserved C-terminal C2H2 zinc fingers motifs, a region rich in the amino acid residues proline and glutamine, a RFX (regulatory factor X)-type winged-helix DNA-binding domain, and a conserved N-terminal AT-rich DNA interaction domain—the last domain for which the protein is named.^[6]

Clinical significance

Mutation studies have revealed ARID2 to be a significant tumor suppressor in many cancer subtypes. ARID2 mutations are prevalent in hepatocellular carcinoma^[7] and melanoma.^[8][9] Mutations are present in a smaller but significant fraction in a wide range of other tumors.^[10] ARID2 mutations are enriched in hepatitis C virus-associated hepatocellular carcinoma in the US and European patient populations compared with the overall mutation frequency.^[6]

References

Further reading

External links

• ARID2+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
• Human ARID2 genome location and ARID2 gene details page in the UCSC Genome Browser.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.