ARL8A

Protein-coding gene in the species Homo sapiens

ARL8A

Available structures

PDB

Ortholog search: PDBe RCSB

List of PDB id codes
1ZD9, 2H18, 4ILE

Identifiers

Aliases

ARL8A, ARL10B, GIE2, ADP ribosylation factor like GTPase 8A

External IDs

OMIM: 616597 MGI: 1915974 HomoloGene: 23600 GeneCards: ARL8A

Gene location (Human)

Chr.	Chromosome 1 (human)^[1]

Band	1q32.1	Start	202,133,404 bp^[1]
Band	1q32.1	End	202,144,743 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 1 (mouse)^[2]

Band	1\|1 E4	Start	135,074,562 bp^[2]
Band	1\|1 E4	End	135,084,007 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

Brodmann area 9

hypothalamus

ganglionic eminence

substantia nigra

cingulate gyrus

inferior ganglion of vagus nerve

putamen

amygdala

nucleus accumbens

caudate nucleus

Top expressed in

superior frontal gyrus

dorsomedial hypothalamic nucleus

cerebellar cortex

piriform cortex

habenula

subiculum

medial dorsal nucleus

prefrontal cortex

primary motor cortex

medial geniculate nucleus

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	nucleotide binding alpha-tubulin binding GTP binding protein binding beta-tubulin binding GTPase activity
Cellular component	cytoplasm spindle midzone lysosomal membrane endosome lysosome midbody extracellular exosome intracellular anatomical structure membrane late endosome membrane plasma membrane azurophil granule membrane ficolin-1-rich granule membrane vacuolar membrane axon cytoplasm spindle cytoskeleton cell junction axon cell projection synapse
Biological process	cell division small GTPase mediated signal transduction cell cycle chromosome segregation neutrophil degranulation anterograde axonal transport protein transport
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


127829


68724

Ensembl


ENSG00000143862


ENSMUSG00000026426

UniProt


Q96BM9


Q8VEH3

RefSeq (mRNA)


NM_138795 NM_001256129


NM_026823

RefSeq (protein)


NP_001243058 NP_620150


NP_081099

Location (UCSC)

Chr 1: 202.13 – 202.14 Mb

Chr 1: 135.07 – 135.08 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

ADP-ribosylation factor-like protein 8A is a protein that in humans is encoded by the ARL8A gene.^[5]^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000143862 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000026426 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Bonaldo MF, Lennon G, Soares MB (September 1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
^ "Entrez Gene: ARL8A ADP-ribosylation factor-like 8A".

External links

Human ARL8A genome location and ARL8A gene details page in the UCSC Genome Browser.

Hofmann I, Munro S (April 2006). "An N-terminally acetylated Arf-like GTPase is localised to lysosomes and affects their motility". Journal of Cell Science. 119 (Pt 8): 1494–503. doi:10.1242/jcs.02958. PMID 16537643.
Okai T, Araki Y, Tada M, Tateno T, Kontani K, Katada T (September 2004). "Novel small GTPase subfamily capable of associating with tubulin is required for chromosome segregation". Journal of Cell Science. 117 (Pt 20): 4705–15. doi:10.1242/jcs.01347. PMID 15331635. S2CID 24407165.
Secombe J, Parkhurst SM (April 2004). "Drosophila Topors is a RING finger-containing protein that functions as a ubiquitin-protein isopeptide ligase for the hairy basic helix-loop-helix repressor protein". The Journal of Biological Chemistry. 279 (17): 17126–33. doi:10.1074/jbc.M310097200. PMID 14871887.