Protein-coding gene in the species Homo sapiens
ATF7 |
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Identifiers |
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Aliases | ATF7, ATFA, activating transcription factor 7 |
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External IDs | OMIM: 606371 MGI: 2443472 HomoloGene: 4994 GeneCards: ATF7 |
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Gene location (Human) |
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| Chr. | Chromosome 12 (human)[1] |
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| Band | 12q13.13 | Start | 53,507,856 bp[1] |
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End | 53,626,410 bp[1] |
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Gene location (Mouse) |
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| Chr. | Chromosome 15 (mouse)[2] |
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| Band | 15|15 F3 | Start | 102,434,381 bp[2] |
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End | 102,533,899 bp[2] |
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RNA expression pattern |
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Bgee | Human | Mouse (ortholog) |
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Top expressed in | - popliteal artery
- gastric mucosa
- minor salivary glands
- ascending aorta
- right coronary artery
- left coronary artery
- sural nerve
- monocyte
- canal of the cervix
- rectum
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| Top expressed in | - yolk sac
- lip
- aortic valve
- ascending aorta
- secondary oocyte
- superior frontal gyrus
- sciatic nerve
- urethra
- female urethra
- thymus
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| More reference expression data |
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BioGPS | | More reference expression data |
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Gene ontology |
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Molecular function | - DNA-binding transcription factor activity
- RNA polymerase II cis-regulatory region sequence-specific DNA binding
- enzyme binding
- DNA binding
- DNA-binding transcription repressor activity, RNA polymerase II-specific
- transcription factor binding
- protein binding
- metal ion binding
- mitogen-activated protein kinase binding
- nucleic acid binding
- DNA-binding transcription factor activity, RNA polymerase II-specific
| Cellular component | - cytoplasm
- nuclear periphery
- nucleus
- nucleoplasm
| Biological process | - viral process
- regulation of transcription, DNA-templated
- negative regulation of transcription by RNA polymerase II
- transcription, DNA-templated
- regulation of transcription by RNA polymerase II
| Sources:Amigo / QuickGO |
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Orthologs |
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Species | Human | Mouse |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNA) | NM_001130059 NM_001130060 NM_001206682 NM_001206683 NM_006856
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NM_001366555 NM_001366556 NM_001366558 NM_001366561 NM_001366562 NM_001366563 |
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NM_146065 NM_001310066 NM_001310067 NM_001310070 |
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RefSeq (protein) | NP_001123532 NP_001193611 NP_001193612 NP_006847 NP_001353484
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NP_001353485 NP_001353487 NP_001353490 NP_001353491 NP_001353492 |
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NP_001296995 NP_001296996 NP_001296999 |
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Location (UCSC) | Chr 12: 53.51 – 53.63 Mb | Chr 15: 102.43 – 102.53 Mb |
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PubMed search | [3] | [4] |
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Wikidata |
View/Edit Human | View/Edit Mouse |
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Cyclic AMP-dependent transcription factor ATF-7 is a protein that in humans is encoded by the ATF7 gene.[5][6][7]
Homonym
In 2001, Peters et al. published a paper showing that ATF-7, a Novel bZIP Protein, interacts with PTP4A1.[6] This ATF-7 is actually ATF5 and not ATF7, as noted by the authors at the end of their paper ("Note Added in Proof—While this manuscript was under review, sequences for mouse and human ATF-5 were deposited in GenBankTM. It appears that ATF-7 and ATF-5 are likely to be the same protein. In addition, an unrelated sequence named ATF7 has also been deposited in GenBankTM. In order to avoid confusion, future work on the protein described in this publication will likely refer to it as either ATF-5 or ATF-5/7.")[6]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000170653 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000099083 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Gaire M, Chatton B, Kedinger C (Aug 1990). "Isolation and characterization of two novel, closely related ATF cDNA clones from HeLa cells". Nucleic Acids Res. 18 (12): 3467–73. doi:10.1093/nar/18.12.3467. PMC 330998. PMID 1694576.
- ^ a b c Peters CS, Liang X, Li S, Kannan S, Peng Y, Taub R, Diamond RH (Apr 2001). "ATF-7, a novel bZIP protein, interacts with the PRL-1 protein-tyrosine phosphatase". J Biol Chem. 276 (17): 13718–26. doi:10.1074/jbc.M011562200. PMID 11278933.
- ^ "Entrez Gene: ATF7 activating transcription factor 7".
Further reading
- Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
- Hamard PJ, Dalbies-Tran R, Hauss C, Davidson I, Kedinger C, Chatton B (2005). "A functional interaction between ATF7 and TAF12 that is modulated by TAF4". Oncogene. 24 (21): 3472–83. doi:10.1038/sj.onc.1208565. PMID 15735663. S2CID 23431610.
- Hamard PJ, Boyer-Guittaut M, Camuzeaux B, Dujardin D, Hauss C, Oelgeschläger T, Vigneron M, Kedinger C, Chatton B (2007). "Sumoylation delays the ATF7 transcription factor subcellular localization and inhibits its transcriptional activity". Nucleic Acids Res. 35 (4): 1134–44. doi:10.1093/nar/gkl1168. PMC 1851647. PMID 17264123.
- Breitwieser W, Lyons S, Flenniken AM, Ashton G, Bruder G, Willington M, Lacaud G, Kouskoff V, Jones N (2007). "Feedback regulation of p38 activity via ATF2 is essential for survival of embryonic liver cells". Genes Dev. 21 (16): 2069–82. doi:10.1101/gad.430207. PMC 1948861. PMID 17699753.
- Newman JR, Keating AE (2003). "Comprehensive identification of human bZIP interactions with coiled-coil arrays". Science. 300 (5628): 2097–101. Bibcode:2003Sci...300.2097N. doi:10.1126/science.1084648. PMID 12805554. S2CID 36715183.
- Newman SP, Bates NP, Vernimmen D, Parker MG, Hurst HC (2000). "Cofactor competition between the ligand-bound oestrogen receptor and an intron 1 enhancer leads to oestrogen repression of ERBB2 expression in breast cancer". Oncogene. 19 (4): 490–7. doi:10.1038/sj.onc.1203416. PMID 10698518. S2CID 7619430.
- Goetz J, Chatton B, Mattei MG, Kedinger C (1997). "Structure and expression of the ATFa gene". J. Biol. Chem. 271 (47): 29589–98. doi:10.1074/jbc.271.47.29589. PMID 8939888.
- Bocco JL, Bahr A, Goetz J, Hauss C, Kallunki T, Kedinger C, Chatton B (1996). "In vivo association of ATFa with JNK/SAP kinase activities". Oncogene. 12 (9): 1971–80. PMID 8649858.
- Pescini R, Kaszubska W, Whelan J, DeLamarter JF, Hooft van Huijsduijnen R (1994). "ATF-a0, a novel variant of the ATF/CREB transcription factor family, forms a dominant transcription inhibitor in ATF-a heterodimers". J. Biol. Chem. 269 (2): 1159–65. doi:10.1016/S0021-9258(17)42236-8. PMID 8288576.
- Zhou Q, Gedrich RW, Engel DA (1995). "Transcriptional repression of the c-fos gene by YY1 is mediated by a direct interaction with ATF/CREB". J. Virol. 69 (7): 4323–30. doi:10.1128/JVI.69.7.4323-4330.1995. PMC 189172. PMID 7769693.
External links
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
(1) Basic domains |
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(1.1) Basic leucine zipper (bZIP) | |
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(1.2) Basic helix-loop-helix (bHLH) | Group A | |
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Group B | |
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Group C bHLH-PAS | |
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Group D | |
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Group E | |
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Group F bHLH-COE | |
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(1.3) bHLH-ZIP | |
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(1.4) NF-1 | |
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(1.5) RF-X | |
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(1.6) Basic helix-span-helix (bHSH) | |
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(2) Zinc finger DNA-binding domains |
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(2.1) Nuclear receptor (Cys4) | subfamily 1 | |
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subfamily 2 | |
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subfamily 3 | |
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subfamily 4 | |
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subfamily 5 | |
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subfamily 6 | |
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subfamily 0 | |
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(2.2) Other Cys4 | |
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(2.3) Cys2His2 | |
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(2.4) Cys6 | |
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(2.5) Alternating composition | |
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(2.6) WRKY | |
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(4) β-Scaffold factors with minor groove contacts |
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(0) Other transcription factors |
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see also transcription factor/coregulator deficiencies |
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