ATG9A

Protein-coding gene in the species Homo sapiens
ATG9A
Identifiers
AliasesATG9A, APG9L1, MGD3208, mATG9, autophagy related 9A
External IDsOMIM: 612204; MGI: 2138446; HomoloGene: 34495; GeneCards: ATG9A; OMA:ATG9A - orthologs
Gene location (Human)
Chromosome 2 (human)
Chr.Chromosome 2 (human)[1]
Chromosome 2 (human)
Genomic location for ATG9A
Genomic location for ATG9A
Band2q35Start219,219,380 bp[1]
End219,229,717 bp[1]
Gene location (Mouse)
Chromosome 1 (mouse)
Chr.Chromosome 1 (mouse)[2]
Chromosome 1 (mouse)
Genomic location for ATG9A
Genomic location for ATG9A
Band1|1 C4Start75,157,504 bp[2]
End75,168,840 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • gastrocnemius muscle

  • skeletal muscle tissue

  • blood

  • stromal cell of endometrium

  • left ventricle

  • prefrontal cortex

  • islet of Langerhans

  • superior frontal gyrus

  • gastric mucosa

  • Brodmann area 9
Top expressed in
  • testicle

  • skeletal muscle tissue

  • quadriceps femoris muscle

  • spermatid

  • superior frontal gyrus

  • cerebellar cortex

  • spermatocyte

  • bone marrow

  • hippocampus proper

  • hypothalamus
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • protein binding
Cellular component
  • integral component of membrane
  • recycling endosome
  • endosome
  • late endosome
  • Golgi apparatus
  • endoplasmic reticulum membrane
  • membrane
  • late endosome membrane
  • phagophore assembly site
  • trans-Golgi network
  • autophagosome membrane
  • endoplasmic reticulum
  • cytoplasmic vesicle
  • autophagosome
  • intracellular membrane-bounded organelle
  • cytoplasmic vesicle membrane
Biological process
  • protein localization to phagophore assembly site
  • autophagosome assembly
  • autophagy
  • autophagy of mitochondrion
  • late nucleophagy
  • protein transport
  • response to nutrient levels
  • transport
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

79065

245860

Ensembl

ENSG00000198925

ENSMUSG00000033124

UniProt

Q7Z3C6

Q68FE2

RefSeq (mRNA)

NM_001077198
NM_024085

NM_001003917
NM_001288612
NM_001288613

RefSeq (protein)

NP_001070666
NP_076990
NP_001070666.1
NP_076990.4

NP_001003917
NP_001275541
NP_001275542
NP_001395154
NP_001395156

NP_001395158
NP_001395159
NP_001395160

Location (UCSC)Chr 2: 219.22 – 219.23 MbChr 1: 75.16 – 75.17 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Autophagy-related protein 9A is a protein that in humans is encoded by the ATG9A gene.[5]

Functional studies indicate that ATG9A plays a role in autophagy.[6][7] and other non-autophagy membrane remodeling processes such as plasma membrane repair.[8] Enzymatically, it is a lipid scramblase.[6][7] ATG9A interacts with IQGAP1 and the ESCRT machinery in membrane remodeling.[8]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000198925 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000033124 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: ATG9A ATG9 autophagy related 9 homolog A (S. cerevisiae)".
  6. ^ a b Maeda S, Yamamoto H, Kinch LN, Garza CM, Takahashi S, Otomo C, et al. (December 2020). "Structure, lipid scrambling activity and role in autophagosome formation of ATG9A". Nature Structural & Molecular Biology. 27 (12): 1194–1201. doi:10.1038/s41594-020-00520-2. PMC 7718406. PMID 33106659.
  7. ^ a b Matoba K, Kotani T, Tsutsumi A, Tsuji T, Mori T, Noshiro D, et al. (December 2020). "Atg9 is a lipid scramblase that mediates autophagosomal membrane expansion". Nature Structural & Molecular Biology. 27 (12): 1185–1193. doi:10.1038/s41594-020-00518-w. PMID 33106658. S2CID 225081989.
  8. ^ a b Claude-Taupin A, Jia J, Bhujabal Z, Garfa-Traoré M, Kumar S, da Silva GP, et al. (July 2021). "ATG9A protects the plasma membrane from programmed and incidental permeabilization". Nature Cell Biology. 23 (8): 846–858. doi:10.1038/s41556-021-00706-w. ISSN 1465-7392. PMC 8276549. PMID 34257406.

Further reading

  • Hartley JL, Temple GF, Brasch MA (November 2000). "DNA cloning using in vitro site-specific recombination". Genome Research. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
  • Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, et al. (March 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Research. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
  • Suzuki Y, Yamashita R, Shirota M, Sakakibara Y, Chiba J, Mizushima-Sugano J, et al. (September 2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions". Genome Research. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
  • Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, et al. (October 2004). "From ORFeome to biology: a functional genomics pipeline". Genome Research. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
  • Yamada T, Carson AR, Caniggia I, Umebayashi K, Yoshimori T, Nakabayashi K, Scherer SW (May 2005). "Endothelial nitric-oxide synthase antisense (NOS3AS) gene encodes an autophagy-related protein (APG9-like2) highly expressed in trophoblast". The Journal of Biological Chemistry. 280 (18): 18283–90. doi:10.1074/jbc.M413957200. PMID 15755735.
  • Mehrle A, Rosenfelder H, Schupp I, del Val C, Arlt D, Hahne F, et al. (January 2006). "The LIFEdb database in 2006". Nucleic Acids Research. 34 (Database issue): D415-8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
  • Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (November 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.

External links

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