AVN-211

Chemical compound
AVN-211
Clinical data
Other namesCD-008-0173
Identifiers
  • 5,7-dimethyl-2-(methylsulfanyl)-3-(phenylsulfonyl)pyrazolo[1,5-a]pyrimidine
CAS Number
  • 1173103-84-8
ChemSpider
  • 26387125
ChEMBL
  • ChEMBL1668500
Chemical and physical data
FormulaC15H15N3O2S2
Molar mass333.42 g·mol−1
3D model (JSmol)
  • Interactive image
  • Cc1cc(n2c(n1)c(c(n2)SC)S(=O)(=O)c3ccccc3)C
InChI
  • InChI=1S/C15H15N3O2S2/c1-10-9-11(2)18-14(16-10)13(15(17-18)21-3)22(19,20)12-7-5-4-6-8-12/h4-9H,1-3H3
  • Key:KSAUCBGUWGWPDL-UHFFFAOYSA-N

AVN-211 (CD-008-0173) is a drug which acts as a highly selective 5-HT6 receptor antagonist and is under development by Avineuro Pharmaceuticals for the treatment of schizophrenia.[1][2][3] In early 2011, it successfully completed phase IIa clinical trials,[1][4] with benefits on positive symptoms and some procognitive effects observed,[5] and in mid 2013, phase IIb clinical trials for schizophrenia began.[6] Avineuro Pharmaceuticals also expressed intention to start clinical trials of AVN-211 for Alzheimer's disease in 2015.[6][7][needs update]

See also

References

  1. ^ a b Ellenbroek BA, Cesura AM (13 October 2014). "Antipsychotics and the Dopamine-Serotonin Connection". In Celanire S, Poli S (eds.). Small Molecule Therapeutics for Schizophrenia. Springer. pp. 31, 37. ISBN 978-3-319-11502-3.
  2. ^ Pharmacology of 5-HT6 receptors. Academic Press. 7 December 2010. pp. 164–. ISBN 978-0-12-384977-9.
  3. ^ "Drug Development in Schizophrenia: Summary and Table". Pharmaceutical Medicine. 28 (5): 265–271. 2014. doi:10.1007/s40290-014-0070-6. ISSN 1178-2595. S2CID 8513976.
  4. ^ "Avineuro Pharmaceuticals, Inc. Reports positive Phase 2a clinical proof of concept trial results on AVN-211, potent small molecule for treatment of schizophrenia". Avineuro Pharmaceuticals, Inc.
  5. ^ Morozova MA, Lepilkina TA, Rupchev GE, Beniashvily AG, Burminskiy DS, Potanin SS, et al. (August 2014). "Add-on clinical effects of selective antagonist of 5HT6 receptors AVN-211 (CD-008-0173) in patients with schizophrenia stabilized on antipsychotic treatment: pilot study". CNS Spectrums. 19 (4): 316–323. doi:10.1017/S1092852913000394. PMID 23768250. S2CID 25486838.
  6. ^ a b "Avineuro Pharmaceuticals, Inc. Announces beginning of Phase 2b clinical studies of AVN-211, potent small molecule for treatment of schizophrenia". Avineuro Pharmaceuticals, Inc.
  7. ^ Ivachtchenko AV, Lavrovsky Y, Ivanenkov YA (March 2016). "AVN-211, Novel and Highly Selective 5-HT6 Receptor Small Molecule Antagonist, for the Treatment of Alzheimer's Disease". Molecular Pharmaceutics. 13 (3): 945–963. doi:10.1021/acs.molpharmaceut.5b00830. PMID 26886442.

External links

  • Pipeline - Avineuro Pharmaceuticals, Inc.
  • v
  • t
  • e
Typical
DisputedAtypicalOthers
  • v
  • t
  • e
5-HT1
5-HT1A
5-HT1B
5-HT1D
5-HT1E
5-HT1F
5-HT2
5-HT2A
5-HT2B
5-HT2C
5-HT3–7
5-HT3
5-HT4
5-HT5A
5-HT6
5-HT7
  • See also: Receptor/signaling modulators
  • Adrenergics
  • Dopaminergics
  • Melatonergics
  • Monoamine reuptake inhibitors and releasing agents
  • Monoamine metabolism modulators
  • Monoamine neurotoxins
Stub icon

This drug article relating to the nervous system is a stub. You can help Wikipedia by expanding it.

  • v
  • t
  • e