Ablukast
Chemical compound
- none
- Investigational
- 6-acetyl-7-[5-(4-acetyl-3-hydroxy-2-propylphenoxy)pentoxy]chroman-2-carboxylic acid
- 96566-25-5
- 57109
- 51496 Y
- 000TKM5BBQ
- D02739 Y
- ChEMBL22016 Y
- DTXSID20869277
- Interactive image
- CCCC1=C(C=CC(=C1O)C(=O)C)OCCCCCOC2=CC3=C(CCC(O3)C(=O)O)C=C2C(=O)C
InChI
- InChI=1S/C28H34O8/c1-4-8-21-23(12-10-20(17(2)29)27(21)31)34-13-6-5-7-14-35-26-16-25-19(15-22(26)18(3)30)9-11-24(36-25)28(32)33/h10,12,15-16,24,31H,4-9,11,13-14H2,1-3H3,(H,32,33) Y
- Key:FGGYJWZYDAROFF-UHFFFAOYSA-N Y
Ablukast (INN) is an experimental drug that is a leukotriene antagonist. It was investigated for potential applications in the treatment of inflammatory conditions, including asthma, skin disorders, and inflammatory bowel disease.[1][2] It reached Phase III clinical trials, but development was discontinued in 1996.[2]
References
- ^ Rosenbach T, Csatò M, Czarnetzki BM (January 1988). "Studies on the role of leukotrienes in murine allergic and irritant contact dermatitis". The British Journal of Dermatology. 118 (1): 1–6. doi:10.1111/j.1365-2133.1988.tb01743.x. PMID 2829957. S2CID 1164113.
- ^ a b "Ablukast". Adis Insight.
External links
- Media related to Ablukast at Wikimedia Commons
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Leukotriene signaling modulators
(ligands)
BLTTooltip Leukotriene B4 receptor |
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CysLTTooltip Cysteinyl leukotriene receptor |
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(inhibitors)
5-LOXTooltip Arachidonate 5-lipoxygenase |
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12-LOXTooltip Arachidonate 12-lipoxygenase |
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15-LOXTooltip Arachidonate 15-lipoxygenase |
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LTA4HTooltip Leukotriene A4 hydrolase |
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LTB4HTooltip Leukotriene B4 ω-hydroxylase |
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LTC4STooltip Leukotriene C4 synthase | |
LTC4HTooltip Leukotriene C4 hydrolase |
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LTD4Tooltip Leukotriene D4 hydrolase |
- See also
- Receptor/signaling modulators
- Prostanoid signaling modulators
This dermatologic drug article is a stub. You can help Wikipedia by expanding it. |
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