Alvameline

Chemical compound

None

Identifiers

3-(2-ethyltetrazol-5-yl)-1-methyl-5,6-dihydro-2H-pyridine

CAS Number

120241-31-8^Y

PubChem CID

178030

ChemSpider

154980^Y

UNII

4XFD7B36M6

ChEMBL

ChEMBL131428^Y

CompTox Dashboard (EPA)

DTXSID30152748

Chemical and physical dataFormulaC₉H₁₅N₅Molar mass193.254 g·mol⁻¹3D model (JSmol)

Interactive image

n1nn(nc1\C2=C\CCN(C)C2)CC

InChI

InChI=1S/C9H15N5/c1-3-14-11-9(10-12-14)8-5-4-6-13(2)7-8/h5H,3-4,6-7H2,1-2H3^Y
Key:RNMOMKCRCIRYCZ-UHFFFAOYSA-N^Y

(verify)

Alvameline (Lu 25-109) is a M₁ receptor agonist and M₂/M₃ receptor antagonist^[1] that was under investigation for the treatment of Alzheimer's disease, but produced poor results in clinical trials^[2] and was subsequently discontinued.

See also

Milameline
Sabcomeline
Tazomeline
Xanomeline

References

^ Sánchez C, Arnt J, Didriksen M, Dragsted N, Moltzen Lenz S, Matz J (June 1998). "In vivo muscarinic cholinergic mediated effects of Lu 25-109, a M1 agonist and M2/M3 antagonist in vitro". Psychopharmacology. 137 (3): 233–240. doi:10.1007/s002130050615. PMID 9683000. S2CID 20740372. Archived from the original on 2000-10-02. Retrieved 2009-12-03.
^ Sramek JJ, Forrest M, Mengel H, Jhee SS, Hourani J, Cutler NR (1998). "A bridging study of LU 25-109 in patients with probable Alzheimer's disease". Life Sciences. 62 (3): 195–202. doi:10.1016/S0024-3205(97)01087-4. PMID 9488097.

v
t
e

Psychoanaleptics: Anti-dementia agents (ATC code N06D and others)

AChE inhibitor medications

Other medications

Experimental BACE inhibitors

v
t
e

Muscarinic acetylcholine receptor modulators

mAChRsTooltip Muscarinic acetylcholine receptors

Precursors
(and prodrugs)

See also: Receptor/signaling modulators; Nicotinic acetylcholine receptor modulators; Acetylcholine metabolism/transport modulators

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