Amedalin

Group of stereoisomers
  • None
Identifiers
  • 3-Methyl-3-[3-(methylamino)propyl]-1-phenyl-1,3-dihydro-2H-indol-2-one
CAS Number
  • 22136-26-1 checkY
    22232-73-1 (HCl)
PubChem CID
  • 31075
ChemSpider
  • 28832 checkY
UNII
  • 2OWK6X9N16
KEGG
  • D02891 ☒N
ChEMBL
  • ChEMBL2110769 ☒N
Chemical and physical dataFormulaC19H22N2OMolar mass294.398 g·mol−13D model (JSmol)
  • Interactive image
  • CC1(C2=CC=CC=C2N(C1=O)C3=CC=CC=C3)CCCNC
InChI
  • InChI=1S/C19H22N2O/c1-19(13-8-14-20-2)16-11-6-7-12-17(16)21(18(19)22)15-9-4-3-5-10-15/h3-7,9-12,20H,8,13-14H2,1-2H3 checkY
  • Key:HBGWAZBZXJBYQD-UHFFFAOYSA-N checkY
 ☒NcheckY (what is this?)  (verify)

Amedalin (UK-3540-1) is an antidepressant which was synthesized in the early 1970s but was never marketed.[1][2] It is a selective norepinephrine reuptake inhibitor, with no significant effects on the reuptake of serotonin and dopamine, and no antihistamine or anticholinergic properties.[2][3]

See also

References

  1. ^ Triggle DJ (1997). Dictionary of pharmacological agents. London: Chapman & Hall. ISBN 978-0-412-46630-4.
  2. ^ a b Cañas-Rodriguez A, Leeming PR (July 1972). "N-Phenyl-2-indolinones and N-phenylindolines. A new class of antidepressant agents". Journal of Medicinal Chemistry. 15 (7): 762–70. doi:10.1021/jm00277a017. PMID 5043876.
  3. ^ Koe BK (December 1976). "Molecular geometry of inhibitors of the uptake of catecholamines and serotonin in synaptosomal preparations of rat brain". Journal of Pharmacology and Experimental Therapeutics. 199 (3): 649–661. PMID 994022.
  • v
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SSRIsTooltip Selective serotonin reuptake inhibitors
SNRIsTooltip Serotonin–norepinephrine reuptake inhibitors
NRIsTooltip Norepinephrine reuptake inhibitors
NDRIsTooltip Norepinephrine–dopamine reuptake inhibitors
NaSSAsTooltip Noradrenergic and specific serotonergic antidepressants
SARIsTooltip Serotonin antagonist and reuptake inhibitors
SMSTooltip Serotonin modulator and stimulators
Others
TCAsTooltip Tricyclic antidepressants
TeCAsTooltip Tetracyclic antidepressants
Others
Non-selective
MAOATooltip Monoamine oxidase A-selective
MAOBTooltip Monoamine oxidase B-selective
Miscellaneous
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DATTooltip Dopamine transporter
(DRIsTooltip Dopamine reuptake inhibitors)
NETTooltip Norepinephrine transporter
(NRIsTooltip Norepinephrine reuptake inhibitors)
SERTTooltip Serotonin transporter
(SRIsTooltip Serotonin reuptake inhibitors)
VMATsTooltip Vesicular monoamine transporters
Others
See also: Receptor/signaling modulators • Monoamine releasing agents • Adrenergics • Dopaminergics • Serotonergics • Monoamine metabolism modulators • Monoamine neurotoxins
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