Amflutizole

Chemical compound
  • none
Identifiers
  • 4-Amino-3-[3-(trifluoromethyl)phenyl]-1,2-thiazole-5-carboxylic acid
CAS Number
  • 82114-19-0 checkY
PubChem CID
  • 54833
ChemSpider
  • 49508 checkY
UNII
  • 83N680M457
KEGG
  • D02896 checkY
ChEMBL
  • ChEMBL2106558
Chemical and physical dataFormulaC11H7F3N2O2SMolar mass288.24 g·mol−13D model (JSmol)
  • Interactive image
  • FC(F)(F)c1cccc(c1)c2nsc(c2N)C(=O)O
InChI
  • InChI=1S/C11H7F3N2O2S/c12-11(13,14)6-3-1-2-5(4-6)8-7(15)9(10(17)18)19-16-8/h1-4H,15H2,(H,17,18) checkY
  • Key:KVMCEGAWQYTFKC-UHFFFAOYSA-N checkY
  (verify)

Amflutizole is a xanthine oxidase inhibitor[1] used for the treatment of gout.

References

  1. ^ O'Regan MH, Smith-Barbour M, Perkins LM, Cao X, Phillis JW (October 1994). "The effect of amflutizole, a xanthine oxidase inhibitor, on ischemia-evoked purine release and free radical formation in the rat cerebral cortex". Neuropharmacology. 33 (10): 1197–201. doi:10.1016/S0028-3908(05)80010-3. PMID 7862255. S2CID 37262919.
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Purine receptor modulators
Receptor
(ligands)
P0 (adenine)
  • Agonists: 8-Aminoadenine
  • Adenine
P1
(adenosine)
P2
(nucleotide)
P2X
(ATPTooltip Adenosine triphosphate)
P2Y
Transporter
(blockers)
CNTsTooltip Concentrative nucleoside transporters
ENTsTooltip Equilibrative nucleoside transporters
PMATTooltip Plasma membrane monoamine transporter
Enzyme
(inhibitors)
XOTooltip Xanthine oxidase
Others
Others
See also: Receptor/signaling modulators
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