Angiopoietin 1

ANGPT1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4EPU, 4JYO, 4K0V
Identifiers
Aliases	ANGPT1, AGP1, AGPT, ANG1, angiopoietin 1, HAE5, AGPT-1
External IDs	OMIM: 601667 MGI: 108448 HomoloGene: 37447 GeneCards: ANGPT1
Gene location (Human) Chr. Chromosome 8 (human)[1] Band 8q23.1 Start 107,249,482 bp[1] End 107,498,055 bp[1]
Gene location (Mouse) Chr. Chromosome 15 (mouse)[2] Band 15 B3.1|15 16.69 cM Start 42,288,119 bp[2] End 42,540,373 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in lower lobe of lung Achilles tendon optic nerve right lung popliteal artery seminal vesicula urethra stromal cell of endometrium visceral pleura gallbladder Top expressed in atrium atrioventricular valve blood intercostal muscle digastric muscle molar right lung soleus muscle right ventricle left lung lobe More reference expression data BioGPS More reference expression data
Gene ontology Molecular function receptor tyrosine kinase binding protein binding signaling receptor binding Cellular component plasma membrane microvillus membrane raft extracellular exosome extracellular region intracellular anatomical structure extracellular space Biological process negative regulation of neuron apoptotic process negative regulation of protein phosphorylation negative regulation of endothelial cell apoptotic process negative regulation of cell adhesion cell differentiation hemopoiesis positive regulation of protein kinase B signaling heparin biosynthetic process positive regulation of receptor internalization regulation of tumor necrosis factor production transmembrane receptor protein tyrosine kinase signaling pathway negative regulation of cytokine production involved in immune response sprouting angiogenesis in utero embryonic development negative regulation of apoptotic process positive regulation of peptidyl-serine phosphorylation MAPK cascade positive regulation of endothelial cell migration multicellular organism development cell-substrate adhesion protein localization to cell surface angiogenesis positive regulation of blood vessel endothelial cell migration positive regulation of ERK1 and ERK2 cascade regulation of macrophage migration inhibitory factor signaling pathway regulation of endothelial cell proliferation positive regulation of phosphatidylinositol 3-kinase signaling positive chemotaxis activation of transmembrane receptor protein tyrosine kinase activity regulation of protein binding regulation of skeletal muscle satellite cell proliferation positive regulation of protein ubiquitination leukocyte migration regulation of I-kappaB kinase/NF-kappaB signaling negative regulation of protein import into nucleus positive regulation of cell adhesion glomerulus vasculature development negative regulation of vascular permeability Tie signaling pathway positive regulation of peptidyl-tyrosine phosphorylation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 284 11600 Ensembl ENSG00000154188 ENSMUSG00000022309 UniProt Q15389 O08538 RefSeq (mRNA) NM_001146 NM_001199859 NM_001314051 NM_139290 NM_009640 NM_001286062 RefSeq (protein) NP_001137 NP_001186788 NP_001300980 NP_001272991 NP_033770 Location (UCSC) Chr 8: 107.25 – 107.5 Mb Chr 15: 42.29 – 42.54 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Angiopoietin 1 is a type of angiopoietin and is encoded by the gene ANGPT1.

Angiopoietins are proteins with important roles in vascular development and angiogenesis. All angiopoietins bind with similar affinity to an endothelial cell-specific tyrosine-protein kinase receptor. The protein encoded by this gene is a secreted glycoprotein that activates the receptor by inducing its tyrosine phosphorylation. It plays a critical role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme. The protein also contributes to blood vessel maturation and stability, and may be involved in early development of the heart.^[5] During pregnancy, angiopoietins act complementary to the VEGF system and contribute to endothelial cell survival and the remodeling of vessels. Few studies have examined the role of angiopoietins in human pregnancy complications like preeclampsia and intrauterine growth restriction (IUGR).

A knockout model of ANGPT1 was introduced in mice embryos. Results showed that embryos began to appear abnormal by day 11 and were dead by day 12.5 of pregnancy. The embryos showed prominent defects in endocardial and myocardial development as well as a less complex vascular network.

^[6][7]

Interactions

Angiopoietin 1 has been shown to interact with TEK tyrosine kinase.^{[8][9][10][11]}

Placental Malaria

Recently, studies in malaria-endemic areas suggest that placental malaria (PM) may be associated with a dysregulation in angiopoietins. Increased levels of angiopoietin-1 appear to be associated with a decrease in placental weight and placental barrier thickness in women infected with Plasmodium (the causative agent of malaria).^[12] In a mouse model of PM, Plasmodium infection of pregnant mice led to decreased angiopoietin-1, increased angiopoietin-2, and an elevated ratio of angiopoietin-2/angiopoietin-1 in the placenta.^[13] This suggests that angiopoietin levels could be clinically significant biomarkers to identify mothers infected with PM.

See also

• Angiopoietin

References

Further reading

External links

• Human ANGPT1 genome location and ANGPT1 gene details page in the UCSC Genome Browser.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.