Aquaporin-1

AQP1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4CSK, 1FQY, 1H6I, 1IH5
Identifiers
Aliases	AQP1, AQP-CHIP, CHIP28, CO, aquaporin 1 (Colton blood group)
External IDs	OMIM: 107776 MGI: 103201 HomoloGene: 68051 GeneCards: AQP1
Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7p14.3 Start 30,911,853 bp[1] End 30,925,517 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6 B3|6 27.38 cM Start 55,313,417 bp[2] End 55,325,540 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ascending aorta right lung upper lobe of left lung right coronary artery pericardium kidney lower lobe of lung left coronary artery gastric mucosa renal medulla Top expressed in right lung right lung lobe ankle fourth ventricle left lung rib kidney body of femur digastric muscle left lung lobe More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transporter activity ammonium transmembrane transporter activity nitric oxide transmembrane transporter activity intracellular cGMP-activated cation channel activity potassium channel activity transmembrane transporter activity carbon dioxide transmembrane transporter activity protein binding water transmembrane transporter activity potassium ion transmembrane transporter activity glycerol transmembrane transporter activity water channel activity ephrin receptor binding identical protein binding channel activity Cellular component cytoplasm nuclear membrane symbiont-containing vacuole membrane membrane nucleus apical plasma membrane integral component of membrane plasma membrane apical part of cell basal plasma membrane integral component of plasma membrane brush border membrane basolateral plasma membrane sarcolemma brush border symbiont-containing vacuole axon neuron projection axon terminus extracellular exosome Biological process cellular response to retinoic acid cellular response to mechanical stimulus cellular response to copper ion cellular response to nitric oxide cellular response to hypoxia cellular response to cAMP carbon dioxide transmembrane transport positive regulation of fibroblast proliferation cellular homeostasis pancreatic juice secretion cGMP biosynthetic process cellular response to stress cellular response to salt stress cellular response to inorganic substance cell volume homeostasis cellular response to UV establishment or maintenance of actin cytoskeleton polarity negative regulation of apoptotic process cellular response to dexamethasone stimulus positive regulation of angiogenesis odontogenesis renal water transport negative regulation of cysteine-type endopeptidase activity involved in apoptotic process cellular response to mercury ion nitric oxide transport cellular hyperosmotic response bicarbonate transport positive regulation of saliva secretion renal water homeostasis multicellular organismal water homeostasis transepithelial water transport carbon dioxide transport cellular response to hydrogen peroxide cerebrospinal fluid secretion potassium ion transmembrane transport ammonium transmembrane transport cation transmembrane transport glomerular filtration potassium ion transport water transport hyperosmotic response response to hormone positive regulation of lamellipodium assembly positive regulation of epithelial cell migration glycerol transport sensory perception of pain lateral ventricle development water homeostasis positive regulation of cell migration secretion by cell secretory granule organization wound healing hyperosmotic salinity response response to estrogen lipid digestion camera-type eye morphogenesis corticotropin secretion renal water absorption metanephric descending thin limb development metanephric proximal straight tubule development metanephric proximal convoluted tubule segment 2 development metanephric glomerulus vasculature development transport cGMP-mediated signaling ion transmembrane transport transmembrane transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 358 11826 Ensembl ENSG00000240583 ENSMUSG00000004655 UniProt P29972 Q6JSD8 Q6JSD7 Q02013 RefSeq (mRNA) NM_198098 NM_000385 NM_001185060 NM_001185061 NM_001185062 NM_001329872 NM_007472 RefSeq (protein) NP_001316801 NP_932766 NP_031498 Location (UCSC) Chr 7: 30.91 – 30.93 Mb Chr 6: 55.31 – 55.33 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Aquaporin 1 (AQP-1) is a protein that in humans is encoded by the AQP1 gene.

AQP-1 is a widely expressed water channel, whose physiological function has been most thoroughly characterized in the kidney. It is found in the basolateral and apical plasma membranes of the proximal tubules, the descending limb of the loop of Henle, and in the descending portion of the vasa recta. Additionally, it is found in red blood cells, vascular endothelium, the gastrointestinal tract, sweat glands, lungs, and the central nervous system.^[5]

Neural AQP-1 receptors are regulated by vasopressin AVPR1A receptor activity.^[6]

Function

Aquaporins are a family of small integral membrane proteins related to the major intrinsic protein (MIP or AQP0). This gene encodes an aquaporin which functions as both a molecular water channel protein and as a non-selective cation channel gated by cyclic guanosine monophosphate (cGMP).^[7] It is a homotetramer with six bilayer spanning domains and N-glycosylation sites. The AQP1 monomer consists of six transmembrane alpha helices that are connected by five loops (A to E).^[8] The protein physically resembles channel proteins and is abundant in erythrocytes and renal tubes. The gene encoding this aquaporin is a possible candidate for disorders involving imbalance in ocular fluid movement.^[9]

See also

• Aquaporin
• Colton antigen system

References

Further reading

External links

• Aquaporin+1 at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
• Gallery of Aquaporin Simulations
• Human AQP1 genome location and AQP1 gene details page in the UCSC Genome Browser.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.