Artemotil

Chemical compound

not available

Routes of
administrationIntramuscular injectionATC code

P01BE04 (WHO)

Pharmacokinetic dataMetabolismHepaticElimination half-life20 hoursIdentifiers

IUPAC name

(5aS,6R,8aS,9R,10S,12R,12aR)-10-ethoxy-3,6,9-trimethyldecahydro-3,12-epoxy[1,2]dioxepino[4,3-i]isochromene

CAS Number

75887-54-6^N

PubChem CID

3000469

ChemSpider

2272064^N

UNII

XGL7GFB9YI

ChEMBL

ChEMBL301267^N

Chemical and physical dataFormulaC₁₇H₂₈O₅Molar mass312.406 g·mol⁻¹3D model (JSmol)

Interactive image

SMILES

CCO[C@@H]1[C@@H]([C@@H]2CC[C@H]([C@H]3[C@]24[C@H](O1)O[C@@](CC3)(OO4)C)C)C

InChI

InChI=1S/C17H28O5/c1-5-18-14-11(3)13-7-6-10(2)12-8-9-16(4)20-15(19-14)17(12,13)22-21-16/h10-15H,5-9H2,1-4H3/t10-,11-,12+,13+,14+,15-,16-,17-/m1/s1^N
Key:NLYNIRQVMRLPIQ-XQLAAWPRSA-N^N

^NY (what is this?) (verify)

Artemotil (INN; also known as β-arteether^[1]), is a fast acting blood schizonticide specifically indicated for the treatment of chloroquine-resistant Plasmodium falciparum malaria and cerebral malaria cases.^[2] It is a semi-synthetic derivative of artemisinin, a natural product of the Chinese plant Artemisia annua. It is currently only used as a second line drug in severe cases of malaria.

References

^ "The International Pharmacopoeia - Sixth Edition - Artemotil" (PDF). 2016. Retrieved 10 April 2019.
^ Yeates RA (April 2002). "Artemotil Artecef". Current Opinion in Investigational Drugs. 3 (4). London, England: 545–9. PMID 12090721.

Antiparasitics – antiprotozoal agents – Chromalveolata antiparasitics (P01)

Alveo-
late

Apicom-
plexa

Conoidasida/
(Coccidiostats)

Cryptosporidiosis	thiazolides (nitazoxanide)
Isosporiasis	trimethoprim/sulfamethoxazole^#
Toxoplasmosis	pyrimethamine sulfadiazine clindamycin atovaquone

Aconoidasida

Malaria

Individual
agents

Hemozoin
inhibitors

Aminoquinolines	(4-): amodiaquine^# chloroquine^# hydroxychloroquine^# (8-): primaquine^# pamaquine^‡ tafenoquine
4-Methanolquinolines	mefloquine^# quinine^# quinidine
Other	lumefantrine + artemether^# halofantrine

Antifolates

DHFR inhibitors	pyrimethamine cycloguanil biguanides chlorproguanil proguanil^#
Sulfonamides	sulfadoxine sulfalene
Co-formulation	sulfadoxine/pyrimethamine (SP)^#

Sesquiterpene
lactones

Other

Combi-
nations

Fixed-dose (co-formulated) ACTs	artemether/lumefantrine^# arterolane/piperaquine artesunate/amodiaquine (ASAQ) artesunate/mefloquine (ASMQ) artesunate/pyronaridine piperaquine/dihydroartemisinin
Other combinations (not co-formulated)	artesunate/mefloquine artesunate/SP quinine/clindamycin quinine/doxycycline quinine/tetracycline