Atiprosin
Chemical compound
- none
- (4aR,12bS)-1-ethyl-12-methyl-4-(propan-2-yl)-1,2,3,4,4a,5,6,12b-octahydropyrazino[2',3':3,4]pyrido[1,2-a]indole
- 89303-63-9
N
- 71770
- 64808
Y
- ALS52889WF
- ChEMBL2111172 N
- Interactive image
- n23c1ccccc1c(c2[C@H]4N(CCN([C@@H]4CC3)C(C)C)CC)C
InChI
- InChI=1S/C20H29N3/c1-5-21-12-13-22(14(2)3)18-10-11-23-17-9-7-6-8-16(17)15(4)19(23)20(18)21/h6-9,14,18,20H,5,10-13H2,1-4H3/t18-,20+/m1/s1Y
- Key:WXNVFYIBELASJW-QUCCMNQESA-NY
N
Y (what is this?) (verify)Atiprosin (developmental code name AY-28,228) is an antihypertensive agent which acts as a selective α1-adrenergic receptor antagonist.[1][2][3][4] It also possesses some antihistamine activity, though it is some 15-fold weaker in this regard than as an alpha blocker.[3] It was never marketed.[1]
See also
- Prazosin
- Ketanserin
References
- ^ a b David J. Triggle (1996). Dictionary of Pharmacological Agents. Boca Raton: Chapman & Hall/CRC. ISBN 0-412-46630-9.
- ^ Jirkovsky I, Santroch G, Baudy R, Oshiro G (February 1987). "Octahydropyrazino[2',3':3,4]pyrido[1,2-a]indoles. A new class of potent antihypertensive agents". Journal of Medicinal Chemistry. 30 (2): 388–94. doi:10.1021/jm00385a022. PMID 3806618.
- ^ a b Grimes D, Rimele TJ, Henry DE, et al. (September 1987). "In vitro isolated tissue studies with atiprosin (AY-28,228): a new antihypertensive compound". Journal of Cardiovascular Pharmacology. 10 (3): 249–58. doi:10.1097/00005344-198709000-00001. PMID 2444771. S2CID 9361176.
- ^ Oshiro G, Wojdan A, Klein M, Metcalf G (September 1987). "Antihypertensive and hypotensive actions of atiprosin (AY-28,228) in rats, dogs, and monkeys". Journal of Cardiovascular Pharmacology. 10 (3): 341–9. doi:10.1097/00005344-198709000-00014. PMID 2444784. S2CID 19086175.
External links
Media related to Atiprosin at Wikimedia Commons
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(antagonize α-adrenergic
vasoconstriction)
| Central |
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| Peripheral |
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| Serotonin receptor antagonists | |
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| Endothelin receptor antagonists (for PHTooltip Pulmonary hypertension) |
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- #WHO-EM
- ‡Withdrawn from market
- Clinical trials:
- †Phase III
- §Never to phase III
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