BAIAP3

Protein-coding gene in the species Homo sapiens
BAIAP3
Identifiers
AliasesBAIAP3, BAP3, BAI1 associated protein 3
External IDsOMIM: 604009 MGI: 2685783 HomoloGene: 20844 GeneCards: BAIAP3
Gene location (Human)
Chromosome 16 (human)
Chr.Chromosome 16 (human)[1]
Chromosome 16 (human)
Genomic location for BAIAP3
Genomic location for BAIAP3
Band16p13.3Start1,333,638 bp[1]
End1,349,441 bp[1]
Gene location (Mouse)
Chromosome 17 (mouse)
Chr.Chromosome 17 (mouse)[2]
Chromosome 17 (mouse)
Genomic location for BAIAP3
Genomic location for BAIAP3
Band17|17 A3.3Start25,461,633 bp[2]
End25,475,338 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • right uterine tube

  • anterior pituitary

  • Brodmann area 9

  • cingulate gyrus

  • hypothalamus

  • amygdala

  • prefrontal cortex

  • nucleus accumbens

  • hippocampus proper

  • islet of Langerhans
Top expressed in
  • arcuate nucleus

  • ventromedial nucleus

  • dorsomedial hypothalamic nucleus

  • median eminence

  • paraventricular nucleus of hypothalamus

  • suprachiasmatic nucleus

  • lateral hypothalamus

  • ventral tegmental area

  • mammillary body

  • dorsal tegmental nucleus
More reference expression data
BioGPS




More reference expression data
Gene ontology
Molecular function
  • syntaxin binding
  • SNARE binding
  • calcium ion binding
  • protein binding
  • phospholipid binding
Cellular component
  • presynapse
  • endoplasmic reticulum
  • dense core granule
  • early endosome membrane
  • cytosol
  • plasma membrane
  • late endosome membrane
  • trans-Golgi network membrane
  • recycling endosome membrane
  • cytoplasm
  • endosome
  • Golgi apparatus
  • membrane
Biological process
  • G protein-coupled receptor signaling pathway
  • dense core granule maturation
  • positive regulation of neurotransmitter secretion
  • regulation of synaptic transmission, GABAergic
  • positive regulation of insulin secretion involved in cellular response to glucose stimulus
  • retrograde transport, endosome to Golgi
  • regulation of dense core granule exocytosis
  • exocytosis
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

8938

545192

Ensembl

ENSG00000007516

ENSMUSG00000047507

UniProt

O94812

Q80TT2

RefSeq (mRNA)
NM_001199096
NM_001199097
NM_001199098
NM_001199099
NM_001286464

NM_003933

NM_001163270

RefSeq (protein)
NP_001186025
NP_001186026
NP_001186027
NP_001186028
NP_001273393

NP_003924

n/a

Location (UCSC)Chr 16: 1.33 – 1.35 MbChr 17: 25.46 – 25.48 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

BAI1-associated protein 3 is a protein that in humans is encoded by the BAIAP3 gene.[5][6]

BAIAP3 was identified as a protein-binding partner of BAI1. BAI1 is a p53-target gene that encodes a brain-specific angiogenesis inhibitor. The protein is a seven-span transmembrane protein and a member of the secretin receptor family. BAIAP3 interacts with the cytoplasmic region of brain-specific angiogenesis inhibitor 1. BAIAP3 also contains two C2 domains, which are often found in proteins involved in signal transduction or membrane trafficking. Its expression pattern and similarity to other proteins suggest that it may be involved in synaptic functions.[6]

Interactions

BAIAP3 has been shown to interact with Brain-specific angiogenesis inhibitor 1.[5]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000007516 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000047507 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b Shiratsuchi T, Oda K, Nishimori H, Suzuki M, Takahashi E, Tokino T, Nakamura Y (Nov 1998). "Cloning and characterization of BAP3 (BAI-associated protein 3), a C2 domain-containing protein that interacts with BAI1". Biochem Biophys Res Commun. 251 (1): 158–65. doi:10.1006/bbrc.1998.9408. PMID 9790924.
  6. ^ a b "Entrez Gene: BAIAP3 BAI1-associated protein 3".

External links

Further reading

  • Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Res. 9 (3): 99–106. doi:10.1093/dnares/9.3.99. PMID 12168954.
  • Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
  • Martin J, Han C, Gordon LA, et al. (2005). "The sequence and analysis of duplication-rich human chromosome 16". Nature. 432 (7020): 988–94. Bibcode:2004Natur.432..988M. doi:10.1038/nature03187. PMID 15616553.
  • Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
  • Daniels RJ, Peden JF, Lloyd C, et al. (2001). "Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16". Hum. Mol. Genet. 10 (4): 339–52. doi:10.1093/hmg/10.4.339. PMID 11157797.
  • Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
  • Nagase T, Ishikawa K, Suyama M, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 5 (5): 277–86. doi:10.1093/dnares/5.5.277. PMID 9872452.
  • Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
  • Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.


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