BCAS3

Protein-coding gene in the species Homo sapiens
BCAS3
Identifiers
AliasesBCAS3, GAOB1, MAAB, breast carcinoma amplified sequence 3, microtubule associated cell migration factor, BCAS3 microtubule associated cell migration factor, PHAF2, HEMARS
External IDsOMIM: 607470 MGI: 2385848 HomoloGene: 9778 GeneCards: BCAS3
Gene location (Human)
Chromosome 17 (human)
Chr.Chromosome 17 (human)[1]
Chromosome 17 (human)
Genomic location for BCAS3
Genomic location for BCAS3
Band17q23.2Start60,677,453 bp[1]
End61,392,838 bp[1]
Gene location (Mouse)
Chromosome 11 (mouse)
Chr.Chromosome 11 (mouse)[2]
Chromosome 11 (mouse)
Genomic location for BCAS3
Genomic location for BCAS3
Band11|11 CStart85,353,167 bp[2]
End85,826,058 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • sural nerve

  • right uterine tube

  • bone marrow cells

  • Achilles tendon

  • prefrontal cortex

  • right coronary artery

  • popliteal artery

  • corpus callosum

  • gastrocnemius muscle

  • left coronary artery
Top expressed in
  • seminal vesicula

  • morula

  • superior frontal gyrus

  • lip

  • yolk sac

  • blastocyst

  • cerebellar cortex

  • blood

  • spermatocyte

  • spermatid
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • histone binding
  • chromatin binding
  • acetyltransferase activator activity
  • beta-tubulin binding
  • histone acetyltransferase binding
  • transcription factor binding
  • protein binding
Cellular component
  • intermediate filament cytoskeleton
  • nucleolus
  • cell periphery
  • cell leading edge
  • cytoplasmic microtubule
  • cytoskeleton
  • nucleus
  • cytoplasm
Biological process
  • angiogenesis
  • cellular response to estrogen stimulus
  • positive regulation of endothelial cell migration
  • positive regulation of GTPase activity
  • positive regulation of intracellular protein transport
  • transcription, DNA-templated
  • positive regulation of actin cytoskeleton reorganization
  • microtubule organizing center organization
  • negative regulation of focal adhesion assembly
  • response to starvation
  • activation of GTPase activity
  • Golgi organization
  • regulation of establishment of cell polarity
  • tube formation
  • regulation of transcription, DNA-templated
  • positive regulation of transcription by RNA polymerase II
  • negative regulation of GTPase activity
  • positive regulation of catalytic activity
  • positive regulation of filopodium assembly
  • vesicle-mediated transport
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

54828

192197

Ensembl

ENSG00000141376

ENSMUSG00000059439

UniProt

Q9H6U6

Q8CCN5

RefSeq (mRNA)
NM_001099432
NM_017679
NM_001320470
NM_001330413
NM_001330414

NM_001353144
NM_001353145
NM_001353146

NM_001166642
NM_001166643
NM_138681

RefSeq (protein)
NP_001092902
NP_001307399
NP_001317342
NP_001317343
NP_060149

NP_001340073
NP_001340074
NP_001340075

NP_001160114
NP_001160115
NP_619622

Location (UCSC)Chr 17: 60.68 – 61.39 MbChr 11: 85.35 – 85.83 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Breast carcinoma amplified sequence 3, also known as BCAS3, is a protein which in humans is encoded by the BCAS3 gene.[5][6] BCAS3 is a gene that is amplified and overexpressed in breast cancer cells.[6]

Function

The BCAS3 gene is regulated by estrogen receptor alpha (ER-α).[7] The PELP1 protein acts as a transcriptional coactivator of estrogen receptor induced BCAS3 gene expression. In addition BCAS3 possesses histone acetyltransferase activity and itself appears to act as a coactivator of ER-α.[8] Furthermore, BCAS3 requires PELP1 to function as a coactivator in ER-α. Hence BCAS3 apparently is involved in a positive feedback loop leading to ER-α mediated signal amplification.[8]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000141376 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000059439 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: BCAS3 breast carcinoma amplified sequence 3".
  6. ^ a b Bärlund M, Monni O, Weaver JD, Kauraniemi P, Sauter G, Heiskanen M, Kallioniemi OP, Kallioniemi A (December 2002). "Cloning of BCAS3 (17q23) and BCAS4 (20q13) genes that undergo amplification, overexpression, and fusion in breast cancer". Genes Chromosomes Cancer. 35 (4): 311–7. doi:10.1002/gcc.10121. PMID 12378525. S2CID 9759638.
  7. ^ Gururaj AE, Singh RR, Rayala SK, Holm C, den Hollander P, Zhang H, Balasenthil S, Talukder AH, Landberg G, Kumar R (April 2006). "MTA1, a transcriptional activator of breast cancer amplified sequence 3". Proc. Natl. Acad. Sci. U.S.A. 103 (17): 6670–5. Bibcode:2006PNAS..103.6670G. doi:10.1073/pnas.0601989103. PMC 1458939. PMID 16617102.
  8. ^ a b Gururaj AE, Peng S, Vadlamudi RK, Kumar R (August 2007). "Estrogen induces expression of BCAS3, a novel estrogen receptor-alpha coactivator, through proline-, glutamic acid-, and leucine-rich protein-1 (PELP1)". Mol. Endocrinol. 21 (8): 1847–60. doi:10.1210/me.2006-0514. PMID 17505058.

External links

Further reading

  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Bärlund M, Monni O, Weaver JD, et al. (2003). "Cloning of BCAS3 (17q23) and BCAS4 (20q13) genes that undergo amplification, overexpression, and fusion in breast cancer". Genes Chromosomes Cancer. 35 (4): 311–7. doi:10.1002/gcc.10121. PMID 12378525. S2CID 9759638.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
  • Gururaj AE, Singh RR, Rayala SK, et al. (2006). "MTA1, a transcriptional activator of breast cancer amplified sequence 3". Proc. Natl. Acad. Sci. U.S.A. 103 (17): 6670–5. Bibcode:2006PNAS..103.6670G. doi:10.1073/pnas.0601989103. PMC 1458939. PMID 16617102.
  • Gururaj AE, Holm C, Landberg G, Kumar R (2006). "Breast cancer-amplified sequence 3, a target of metastasis-associated protein 1, contributes to tamoxifen resistance in premenopausal patients with breast cancer". Cell Cycle. 5 (13): 1407–10. doi:10.4161/cc.5.13.2924. PMID 16855396.
  • Gururaj AE, Peng S, Vadlamudi RK, Kumar R (2007). "Estrogen induces expression of BCAS3, a novel estrogen receptor-alpha coactivator, through proline-, glutamic acid-, and leucine-rich protein-1 (PELP1)". Mol. Endocrinol. 21 (8): 1847–60. doi:10.1210/me.2006-0514. PMID 17505058.
  • v
  • t
  • e
Coactivators
Corepressors
ATP-dependent remodeling factors
  • Chromatin Structure Remodeling (RSC) Complex
  • SWI/SNF



Stub icon

This article on a gene on human chromosome 17 is a stub. You can help Wikipedia by expanding it.

  • v
  • t
  • e