BD-1047

Chemical compound

none

Identifiers

IUPAC name

N'-[2-(3,4-dichlorophenyl)ethyl]-N,N,N'-trimethylethane-1,2-diamine

CAS Number

138356-20-4^N

PubChem CID

188914

IUPHAR/BPS

6680

ChemSpider

164154^Y

UNII

1S3X75QGDO

ChEMBL

ChEMBL143360^Y

CompTox Dashboard (EPA)

DTXSID70160640

Chemical and physical dataFormulaC₁₃H₂₀Cl₂N₂Molar mass275.22 g·mol⁻¹3D model (JSmol)

Interactive image

SMILES

Clc1ccc(CCN(C)CCN(C)C)cc1Cl

InChI

InChI=1S/C13H20Cl2N2/c1-16(2)8-9-17(3)7-6-11-4-5-12(14)13(15)10-11/h4-5,10H,6-9H2,1-3H3^Y
Key:MGVRNMUKTZOQOW-UHFFFAOYSA-N^Y

^NY (what is this?) (verify)

BD-1047 is a sigma receptor antagonist, selective for the σ₁ subtype. It has effects in animal studies suggestive of antipsychotic activity and may also be useful in the treatment of neuropathic pain.^[1]^[2]

More recent studies also suggest a novel role for BD-1047 in attenuating ethanol-induced neurotoxicity in vitro, and additional research is being conducted on this compound as a possible pharmacotherapy for alcohol use disorder (AUD) ^[3]

References

^ Skuza G, Rogóz Z (2006). "Effect of BD 1047, a sigma1 receptor antagonist, in the animal models predictive of antipsychotic activity". Pharmacological Reports. 58 (5): 626–35. PMID 17085854.
^ Roh DH, Kim HW, Yoon SY, Seo HS, Kwon YB, Kim KW, Han HJ, Beitz AJ, Na HS, Lee JH (November 2008). "Intrathecal injection of the sigma(1) receptor antagonist BD1047 blocks both mechanical allodynia and increases in spinal NR1 expression during the induction phase of rodent neuropathic pain". Anesthesiology. 109 (5): 879–89. doi:10.1097/ALN.0b013e3181895a83. PMID 18946301.
^ Reynolds AR, Saunders MA, Prendergast MA (2016). "Ethanol Stimulates Endoplasmic Reticulum Inositol Triphosphate and Sigma Receptors to Promote Withdrawal-Associated Loss of Neuron-Specific Nuclear Protein/Fox-3". Alcohol Clin Exp Res. 40 (7): 1454–61. doi:10.1111/acer.13097. PMC 6662182. PMID 27177604.