Bendazac

Chemical compound
  • M02AA11 (WHO) S01BC07 (WHO)
Identifiers
  • [(1-benzyl-1H-indazol-3-yl)oxy]acetic acid
CAS Number
  • 20187-55-7 checkY
PubChem CID
  • 2313
ChemSpider
  • 2223 checkY
UNII
  • G4AG71204O
KEGG
  • D01594 checkY
ChEBI
  • CHEBI:31257 ☒N
ChEMBL
  • ChEMBL1089221 checkY
CompTox Dashboard (EPA)
  • DTXSID1048334 Edit this at Wikidata
ECHA InfoCard100.039.594 Edit this at WikidataChemical and physical dataFormulaC16H14N2O3Molar mass282.299 g·mol−13D model (JSmol)
  • Interactive image
  • O=C(O)COc2nn(c1ccccc12)Cc3ccccc3
InChI
  • InChI=1S/C16H14N2O3/c19-15(20)11-21-16-13-8-4-5-9-14(13)18(17-16)10-12-6-2-1-3-7-12/h1-9H,10-11H2,(H,19,20) checkY
  • Key:BYFMCKSPFYVMOU-UHFFFAOYSA-N checkY
 ☒NcheckY (what is this?)  (verify)

Bendazac (or bendazolic acid) is a nonsteroidal anti-inflammatory drug (NSAID) used for joint and muscular pain.[1]

Synthesis

Principal action is inhibition of protein denaturation.

Bendazac synthesis: BE 699226 ; G. Palazzo, U.S. patent 3,470,194 (1967, 1969 both to Francesco Angelini).

Use of chloroacetamide in the alkylation step, followed by acid hydrolysis produces bendazac (instead of benzydamine).

See also

  • Benzydamine

References

  1. ^ Balfour JA, Clissold SP (April 1990). "Bendazac lysine. A review of its pharmacological properties and therapeutic potential in the management of cataracts". Drugs. 39 (4): 575–96. doi:10.2165/00003495-199039040-00007. PMID 2190795. S2CID 46956362.


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Non-steroidal anti-inflammatory drugs (NSAIDs) (primarily M01A and M02A, also N02BA)
pyrazolones /
pyrazolidinessalicylatesacetic acid derivatives
and related substancesoxicamspropionic acid
derivatives (profens)n-arylanthranilic
acids (fenamates)COX-2 inhibitors
(coxibs)otherNSAID
combinations
Key: underline indicates initially developed first-in-class compound of specific group; #WHO-Essential Medicines; withdrawn drugs; veterinary use.
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Receptor
(ligands)
DP (D2)Tooltip Prostaglandin D2 receptor
DP1Tooltip Prostaglandin D2 receptor 1
DP2Tooltip Prostaglandin D2 receptor 2
EP (E2)Tooltip Prostaglandin E2 receptor
EP1Tooltip Prostaglandin EP1 receptor
  • Antagonists: AH-6809
  • ONO-8130
  • SC-19220
  • SC-51089
  • SC-51322
EP2Tooltip Prostaglandin EP2 receptor
  • Antagonists: AH-6809
  • PF-04418948
  • TG 4-155
EP3Tooltip Prostaglandin EP3 receptor
  • Antagonists: L-798106
EP4Tooltip Prostaglandin EP4 receptor
  • Antagonists: Grapiprant
  • GW-627368
  • L-161982
  • ONO-AE3-208
Unsorted
  • Agonists: 16,16-Dimethyl Prostaglandin E2
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FP (F)Tooltip Prostaglandin F receptor
IP (I2)Tooltip Prostacyclin receptor
  • Antagonists: RO1138452
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Enzyme
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PGD2STooltip Prostaglandin D synthase
PGESTooltip Prostaglandin E synthase
HQL-79
PGFSTooltip Prostaglandin F synthase
PGI2STooltip Prostacyclin synthase
TXASTooltip Thromboxane A synthase
Others
See also
Receptor/signaling modulators
Leukotriene signaling modulators


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