Benorilate
Chemical compound
- N02BA10 (WHO)
- 4-acetamidophenyl 2-(acetyloxy)benzoate
- 5003-48-5
N
- 21102
- 19846 N
- W1QX9DV96G
- ChEMBL162036 N
- DTXSID5022649
- Interactive image
- O=C(C)Oc2ccccc2C(=O)Oc1ccc(NC(C)=O)cc1
InChI
- InChI=1S/C17H15NO5/c1-11(19)18-13-7-9-14(10-8-13)23-17(21)15-5-3-4-6-16(15)22-12(2)20/h3-10H,1-2H3,(H,18,19)N
- Key:FEJKLNWAOXSSNR-UHFFFAOYSA-NN
N
Y (what is this?) (verify)Benorilate (INN), or benorylate, is an ester-linked codrug of aspirin with paracetamol. It is used as an anti-inflammatory and antipyretic medication. In the treatment of childhood fever, it has been shown to be inferior to paracetamol and aspirin taken separately. In addition, because it is converted to aspirin, benorylate is not recommended in children due to concerns about Reye syndrome.[1]
Synthesis
Acetyl salicoyl chloride (1) is reacted with paracetamol (2) to give benorilate (3).[2][3][4][5]
Partial saponification of benorilate leads to acetaminosalol (phenetsal).[6]
References
- ^ Similä S, Keinänen S, Kouvalainen K (December 1975). "Oral antipyretic therapy: evaluation of benorylate, an ester of acetylsalicylic acid and paracetamol". European Journal of Pediatrics. 121 (1): 15–20. doi:10.1007/bf00464391. PMID 2478. S2CID 21112438.
- ^ Thieme
- ^ NL6504517 idem Andrew Robertson, U.S. patent 3,431,293 (1969 to Sterling Drug Inc)
- ^ Mario Portelli & Giorgio Renzi, DE 2402231 (1974 to Whitefin Holding SA)
- ^ Huang Xiaocheng, et al. CN 111056968 (2020 to Guangxi University of Science and Technology)
- ^ Moerk Nielsen, N., Bundgaard, H. (March 1989). "Evaluation of glycolamide esters and various other esters of aspirin as true aspirin prodrugs". Journal of Medicinal Chemistry. 32 (3): 727–734. doi:10.1021/jm00123a040. PMID 2918521.
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modulators
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| Sodium blockers |
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| Potassium openers |
- #WHO-EM
- ‡Withdrawn from market
- Clinical trials:
- †Phase III
- §Never to phase III
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| pyrazolones / pyrazolidines | |
| salicylates | |
| acetic acid derivatives and related substances | |
| oxicams |
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| propionic acid derivatives (profens) |
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| n-arylanthranilic acids (fenamates) | |
| COX-2 inhibitors (coxibs) | |
| other | |
| NSAID combinations | |
Key: underline indicates initially developed first-in-class compound of specific group; #WHO-Essential Medicines; †withdrawn drugs; ‡veterinary use. | |
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