CACNB3

Protein-coding gene in humans
CACNB3
Identifiers
AliasesCACNB3, CAB3, CACNLB3, calcium voltage-gated channel auxiliary subunit beta 3
External IDsOMIM: 601958 MGI: 103307 HomoloGene: 20187 GeneCards: CACNB3
Gene location (Human)
Chromosome 12 (human)
Chr.Chromosome 12 (human)[1]
Chromosome 12 (human)
Genomic location for CACNB3
Genomic location for CACNB3
Band12q13.12Start48,813,794 bp[1]
End48,828,941 bp[1]
Gene location (Mouse)
Chromosome 15 (mouse)
Chr.Chromosome 15 (mouse)[2]
Chromosome 15 (mouse)
Genomic location for CACNB3
Genomic location for CACNB3
Band15 F1|15 54.64 cMStart98,528,721 bp[2]
End98,542,410 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • ganglionic eminence

  • frontal pole

  • right uterine tube

  • endothelial cell

  • prefrontal cortex

  • stromal cell of endometrium

  • amygdala

  • cingulate gyrus

  • dorsolateral prefrontal cortex

  • Brodmann area 9
Top expressed in
  • habenula

  • superior frontal gyrus

  • entorhinal cortex

  • olfactory epithelium

  • external carotid artery

  • internal carotid artery

  • prefrontal cortex

  • hippocampus proper

  • primary motor cortex

  • olfactory bulb
More reference expression data
BioGPS


More reference expression data
Gene ontology
Molecular function
  • protein kinase binding
  • voltage-gated ion channel activity
  • voltage-gated calcium channel activity
  • high voltage-gated calcium channel activity
  • calcium channel activity
  • protein binding
  • calcium channel regulator activity
Cellular component
  • apical plasma membrane
  • membrane
  • cytosol
  • plasma membrane
  • voltage-gated calcium channel complex
  • L-type voltage-gated calcium channel complex
  • cytoplasm
Biological process
  • membrane depolarization
  • regulation of ion transmembrane transport
  • ion transport
  • regulation of voltage-gated calcium channel activity
  • neuromuscular junction development
  • calcium ion transmembrane transport
  • calcium ion transport
  • regulation of membrane repolarization during action potential
  • calcium ion transport into cytosol
  • protein localization to plasma membrane
  • chemical synaptic transmission
  • calcium ion transmembrane transport via high voltage-gated calcium channel
  • detection of mechanical stimulus involved in sensory perception of pain
  • positive regulation of protein targeting to membrane
  • cellular response to oxygen-glucose deprivation
  • negative regulation of voltage-gated calcium channel activity
  • positive regulation of voltage-gated calcium channel activity
  • positive regulation of high voltage-gated calcium channel activity
  • regulation of membrane hyperpolarization
  • negative regulation of detection of mechanical stimulus involved in sensory perception of touch
  • positive regulation of excitatory postsynaptic potential
  • T cell receptor signaling pathway
  • cardiac conduction
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

784

12297

Ensembl

ENSG00000167535

ENSMUSG00000003352

UniProt

P54284

P54285

RefSeq (mRNA)

NM_000725
NM_001206915
NM_001206916
NM_001206917

NM_001044741
NM_001286226
NM_007581
NM_001356543

RefSeq (protein)

NP_000716
NP_001193844
NP_001193845
NP_001193846

NP_001038206
NP_001273155
NP_031607
NP_001343472

Location (UCSC)Chr 12: 48.81 – 48.83 MbChr 15: 98.53 – 98.54 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Voltage-dependent L-type calcium channel subunit beta-3 is a protein that in humans is encoded by the CACNB3 gene.[5][6]

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000167535 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000003352 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Collin T, Lory P, Taviaux S, Courtieu C, Guilbault P, Berta P, Nargeot J (Apr 1994). "Cloning, chromosomal location and functional expression of the human voltage-dependent calcium-channel beta 3 subunit". Eur J Biochem. 220 (1): 257–62. doi:10.1111/j.1432-1033.1994.tb18621.x. PMID 8119293.
  6. ^ "Entrez Gene: CACNB3 calcium channel, voltage-dependent, beta 3 subunit".

Further reading

  • Yamada Y, Masuda K, Li Q, et al. (1995). "The structures of the human calcium channel alpha 1 subunit (CACNL1A2) and beta subunit (CACNLB3) genes". Genomics. 27 (2): 312–9. doi:10.1006/geno.1995.1048. PMID 7557998.
  • Rosenfeld MR, Wong E, Dalmau J, et al. (1993). "Cloning and characterization of a Lambert-Eaton myasthenic syndrome antigen". Ann. Neurol. 33 (1): 113–20. doi:10.1002/ana.410330126. PMID 8494331. S2CID 24241609.
  • Murakami M, Wissenbach U, Flockerzi V (1996). "Gene structure of the murine calcium channel beta3 subunit, cDNA and characterization of alternative splicing and transcription products". Eur. J. Biochem. 236 (1): 138–43. doi:10.1111/j.1432-1033.1996.t01-1-00138.x. PMID 8617257.
  • Scott VE, De Waard M, Liu H, et al. (1996). "Beta subunit heterogeneity in N-type Ca2+ channels". J. Biol. Chem. 271 (6): 3207–12. doi:10.1074/jbc.271.6.3207. PMID 8621722.
  • Bell DC, Butcher AJ, Berrow NS, et al. (2001). "Biophysical properties, pharmacology, and modulation of human, neuronal L-type (alpha(1D), Ca(V)1.3) voltage-dependent calcium currents". J. Neurophysiol. 85 (2): 816–27. doi:10.1152/jn.2001.85.2.816. PMID 11160515. S2CID 147295966.
  • Colecraft HM, Alseikhan B, Takahashi SX, et al. (2002). "Novel functional properties of Ca(2+) channel beta subunits revealed by their expression in adult rat heart cells". J. Physiol. 541 (Pt 2): 435–52. doi:10.1113/jphysiol.2002.018515. PMC 2290333. PMID 12042350.
  • Murakami M, Fleischmann B, De Felipe C, et al. (2002). "Pain perception in mice lacking the beta3 subunit of voltage-activated calcium channels". J. Biol. Chem. 277 (43): 40342–51. doi:10.1074/jbc.M203425200. hdl:10261/310195. PMID 12161429.
  • Qin N, Yagel S, Momplaisir ML, et al. (2002). "Molecular cloning and characterization of the human voltage-gated calcium channel alpha(2)delta-4 subunit". Mol. Pharmacol. 62 (3): 485–96. doi:10.1124/mol.62.3.485. PMID 12181424.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Chen YH, Li MH, Zhang Y, et al. (2004). "Structural basis of the alpha1-beta subunit interaction of voltage-gated Ca2+ channels". Nature. 429 (6992): 675–80. Bibcode:2004Natur.429..675C. doi:10.1038/nature02641. PMID 15170217. S2CID 4422712.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Vendel AC, Terry MD, Striegel AR, et al. (2006). "Alternative splicing of the voltage-gated Ca2+ channel beta4 subunit creates a uniquely folded N-terminal protein binding domain with cell-specific expression in the cerebellar cortex". J. Neurosci. 26 (10): 2635–44. doi:10.1523/JNEUROSCI.0067-06.2006. PMC 6675161. PMID 16525042.

External links

  • v
  • t
  • e
  • 1vyt: BETA3 SUBUNIT COMPLEXED WITH AID
    1vyt: BETA3 SUBUNIT COMPLEXED WITH AID
  • 1vyu: BETA3 SUBUNIT OF VOLTAGE-GATED CA2+-CHANNEL
    1vyu: BETA3 SUBUNIT OF VOLTAGE-GATED CA2+-CHANNEL
  • v
  • t
  • e
Ligand-gated
Voltage-gated
Constitutively active
Proton-gated
Voltage-gated
Calcium-activated
Inward-rectifier
Tandem pore domain
Voltage-gated
Miscellaneous
Cl−: Chloride channel
H+: Proton channel
M+: CNG cation channel
M+: TRP cation channel
H2O (+ solutes): Porin
Cytoplasm: Gap junction
By gating mechanism
Ion channel class
see also disorders


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