CCL11

CCL11
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1EOT, 2EOT, 2MPM
Identifiers
Aliases	CCL11, SCYA11, C-C motif chemokine ligand 11
External IDs	OMIM: 601156 MGI: 103576 HomoloGene: 7929 GeneCards: CCL11
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q12 Start 34,285,742 bp[1] End 34,288,334 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11 C|11 49.84 cM Start 81,948,649 bp[2] End 81,953,781 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in pylorus cardia cecum appendix right ventricle fundus duodenum rectum jejunal mucosa smooth muscle tissue Top expressed in cervix intercostal muscle sciatic nerve white adipose tissue lip parotid gland ankle stomach sternocleidomastoid muscle quadriceps femoris muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function cytokine activity protein binding chemokine activity CCR3 chemokine receptor binding protein dimerization activity receptor ligand activity CCR chemokine receptor binding Cellular component extracellular region extracellular space intracellular anatomical structure Biological process G protein-coupled receptor signaling pathway positive regulation of endothelial cell proliferation positive regulation of actin filament polymerization response to interleukin-4 branching involved in mammary gland duct morphogenesis monocyte chemotaxis actin filament organization positive regulation of cell migration chemokine-mediated signaling pathway response to interleukin-13 cellular response to tumor necrosis factor response to virus cellular calcium ion homeostasis mast cell chemotaxis neutrophil chemotaxis positive regulation of angiogenesis mammary duct terminal end bud growth chemotaxis protein phosphorylation positive regulation of GTPase activity cell adhesion cytoskeleton organization cellular response to interleukin-1 immune response positive regulation of ERK1 and ERK2 cascade regulation of cell shape cellular response to interferon-gamma lymphocyte chemotaxis response to radiation inflammatory response chronic inflammatory response signal transduction eosinophil chemotaxis antimicrobial humoral immune response mediated by antimicrobial peptide regulation of signaling receptor activity cytokine-mediated signaling pathway ERK1 and ERK2 cascade Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6356 20292 Ensembl ENSG00000172156 ENSMUSG00000020676 UniProt P51671 P48298 RefSeq (mRNA) NM_002986 NM_011330 RefSeq (protein) NP_002977 NP_035460 Location (UCSC) Chr 17: 34.29 – 34.29 Mb Chr 11: 81.95 – 81.95 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

C-C motif chemokine 11 also known as eosinophil chemotactic protein and eotaxin-1 is a protein that in humans is encoded by the CCL11 gene. This gene is encoded on three exons and is located on chromosome 17.^[5][6]

Function

CCL11 is a small cytokine belonging to the CC chemokine family. CCL11 selectively recruits eosinophils by inducing their chemotaxis, and therefore, is implicated in allergic responses.^[7][8][9] The effects of CCL11 are mediated by its binding to a G-protein-linked receptor known as a chemokine receptor. Chemokine receptors for which CCL11 is a ligand include CCR2,^[10] CCR3^[5] and CCR5.^[10] However, it has been found that eotaxin-1 (CCL11) has high degree selectivity for its receptor, such that they are inactive on neutrophils and monocytes, which do not express CCR3.^[11]

Clinical significance

Increased CCL11 levels in blood plasma are associated with aging in mice and humans.^[12] Additionally, it has been demonstrated that exposing young mice to CCL11 or the blood plasma of older mice decreases their neurogenesis and cognitive performance on behavioural tasks thought to be dependent on neurogenesis in the hippocampus.^[12]

Higher plasma concentrations of CCL11 have been found in current cannabis users compared to past users and those who had never used. CCL11 has also been found in higher concentrations in people with schizophrenia; cannabis is a known trigger of schizophrenia.^[13]

It's also a biomarker for CTE or punch-drunk syndrome.^[14]

During periods of bone inflammation, CCL11 and CCR3 are upregulated. This is associated with an increase in osteoclast activity.^[15]

In 2022, Monje et al demonstrated that elevated levels of CCL11 may contribute to the brain fog associated with both chemotherapy and so-called long covid^[16][17]

References

External links

• Human CCL11 genome location and CCL11 gene details page in the UCSC Genome Browser.

Further reading