CCL14

Mammalian protein found in Homo sapiens
chemokine (C-C motif) ligand 14
Identifiers
SymbolCCL14
Alt. symbolsSCYA14, HCC-1, HCC-3, NCC-2, SCYL2, CKb1, MCIF
NCBI gene6358
HGNC10612
OMIM601392
RefSeqNM_032962
UniProtQ16627
Other data
LocusChr. 17 q11.2
Search for
StructuresSwiss-model
DomainsInterPro

Chemokine (C-C motif) ligand 14 (CCL14) is a small cytokine belonging to the CC chemokine family. It is also commonly known as HCC-1. It is produced as a protein precursor that is processed to generate a mature active protein containing 74 amino acids that and is 46% identical in amino acid composition to CCL3 and CCL4. This chemokine is expressed in various tissues including spleen, bone marrow, liver, muscle, and gut.[1] CCL14 activates monocytes, but does not induce their chemotaxis. Human CCL14 is located on chromosome 17 within a cluster of other chemokines belonging to the CC family.[2]

References

  1. ^ Schulz-Knappe et al., HCC-1, a novel chemokine from human plasma. J. Exp. Med., 1996, 183: 295-299.
  2. ^ Naruseet al., A YAC contig of the human CC chemokine genes clustered on chromosome 17q11.2. Genomics, 1996, 34: 236-240.


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Cell signaling: cytokines
By family
Chemokine
CCL
CXCL
CX3CL
XCL
TNF
Interleukin
Type I
(grouped by
receptor
subunit)
γ chain
β chain
IL6 like/gp130
IL12 family/IL12RB1
Other
Type II
IL10 family
Interferon
I
II
Ig superfamily
IL17 family
Other
By function/
cell
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CC
CCR1
CCR2
CCR3
CCR4
CCR5
CCR6
CCR7
CCR8
CCR9
CCR10
CCR11
Ungrouped
CXC
CXCR1
(IL-8Rα)
  • Antagonists: Navarixin
  • NAMs: Ladarixin
  • Reparixin (repertaxin)
CXCR2
(IL-8Rβ)
  • Antagonists: Danirixin
  • Elubrixin
  • Navarixin
  • NAMs: Ladarixin
  • Reparixin (repertaxin)
CXCR3
CXCR4
CXCR5
CXCR6
CXCR7
C (XC)
XCR1
CX3C
CX3CR1
Others
CCBP2
CMKLR1


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