CD151

Protein-coding gene in the species Homo sapiens
CD151
Identifiers
AliasesCD151, GP27, MER2, PETA-3, RAPH, SFA1, TSPAN24, CD151 molecule (Raph blood group), EBS7
External IDsOMIM: 602243 MGI: 1096360 HomoloGene: 20916 GeneCards: CD151
Gene location (Human)
Chromosome 11 (human)
Chr.Chromosome 11 (human)[1]
Chromosome 11 (human)
Genomic location for CD151
Genomic location for CD151
Band11p15.5Start832,887 bp[1]
End839,831 bp[1]
Gene location (Mouse)
Chromosome 7 (mouse)
Chr.Chromosome 7 (mouse)[2]
Chromosome 7 (mouse)
Genomic location for CD151
Genomic location for CD151
Band7 F5|7 86.82 cMStart141,047,305 bp[2]
End141,051,386 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • ascending aorta

  • right coronary artery

  • left coronary artery

  • popliteal artery

  • stromal cell of endometrium

  • body of pancreas

  • upper lobe of left lung

  • right lung

  • left uterine tube

  • gastric mucosa
Top expressed in
  • medullary collecting duct

  • Paneth cell

  • renal corpuscle

  • iris

  • carotid body

  • ciliary body

  • white adipose tissue

  • right lung lobe

  • external carotid artery

  • adrenal gland
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • integrin binding
  • protein binding
Cellular component
  • cytosol
  • membrane
  • focal adhesion
  • basement membrane
  • integral component of membrane
  • integral component of plasma membrane
  • plasma membrane
  • cell surface
Biological process
  • cell adhesion
  • cell surface receptor signaling pathway
  • hemidesmosome assembly
  • T cell proliferation
  • cell migration
  • positive regulation of cell migration
  • wound healing, spreading of cells
  • positive regulation of endocytosis
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

977

12476

Ensembl

ENSG00000177697

ENSMUSG00000025510

UniProt

P48509
Q6ZNZ0

O35566

RefSeq (mRNA)

NM_139030
NM_001039490
NM_004357
NM_139029

NM_001111049
NM_001111050
NM_009842

RefSeq (protein)
NP_001034579
NP_004348
NP_620598
NP_620599
NP_001034579.1

NP_004348.2
NP_620598.1
NP_620599.1

NP_001104519
NP_001104520
NP_033972

Location (UCSC)Chr 11: 0.83 – 0.84 MbChr 7: 141.05 – 141.05 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

CD151 molecule (Raph blood group), also known as CD151 (Cluster of Differentiation 151), is a human gene.[5]

Function

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins and other transmembrane 4 superfamily proteins. It is involved in cellular processes including cell adhesion and may regulate integrin trafficking and/or function. This protein enhances cell motility, invasion and metastasis of cancer cells. Multiple alternatively spliced transcript variants that encode the same protein have been described for this gene.[5] Abnormalities in CD151 have been implicated in a form of epidermolysis bullosa.[6][7]

Interactions

Fibrosarcoma cells, reportedly stained with an antibody binding to CD151 (green) and a dye for the nucleus (blue).

CD151 has been shown to interact with CD46.[8]

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000177697 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000025510 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: CD151 CD151 molecule (Raph blood group)".
  6. ^ Bardhan, Ajoy; Bruckner-Tuderman, Leena; Chapple, Iain L. C.; Fine, Jo-David; Harper, Natasha; Has, Cristina; Magin, Thomas M.; Marinkovich, M. Peter; Marshall, John F.; McGrath, John A.; Mellerio, Jemima E. (2020-09-24). "Epidermolysis bullosa". Nature Reviews Disease Primers. 6 (1): 78. doi:10.1038/s41572-020-0210-0. ISSN 2056-676X. PMID 32973163. S2CID 221861310.
  7. ^ Vahidnezhad, Hassan; Youssefian, Leila; Saeidian, Amir Hossein; Mahmoudi, Hamidreza; Touati, Andrew; Abiri, Maryam; Kajbafzadeh, Abdol-Mohammad; Aristodemou, Sophia; Liu, Lu; McGrath, John A.; Ertel, Adam (2018-03-01). "Recessive mutation in tetraspanin CD151 causes Kindler syndrome-like epidermolysis bullosa with multi-systemic manifestations including nephropathy". Matrix Biology. 66: 22–33. doi:10.1016/j.matbio.2017.11.003. hdl:11573/1182681. ISSN 0945-053X. PMID 29138120. S2CID 3812225.
  8. ^ Lozahic S, Christiansen D, Manié S, Gerlier D, Billard M, Boucheix C, Rubinstein E (March 2000). "CD46 (membrane cofactor protein) associates with multiple beta1 integrins and tetraspans". Eur. J. Immunol. 30 (3): 900–7. doi:10.1002/1521-4141(200003)30:3<900::AID-IMMU900>3.0.CO;2-X. PMID 10741407.

Further reading

  • Berditchevski F (2002). "Complexes of tetraspanins with integrins: more than meets the eye". J. Cell Sci. 114 (Pt 23): 4143–51. doi:10.1242/jcs.114.23.4143. PMID 11739647.
  • Ashman LK (2003). "CD151". J. Biol. Regul. Homeost. Agents. 16 (3): 223–6. PMID 12456024.
  • Ashman LK, Aylett GW, Mehrabani PA, Bendall LJ, Niutta S, Cambareri AC, Cole SR, Berndt MC (1992). "The murine monoclonal antibody, 14A2.H1, identifies a novel platelet surface antigen". Br. J. Haematol. 79 (2): 263–70. doi:10.1111/j.1365-2141.1991.tb04531.x. PMID 1958484. S2CID 6682391.
  • Fitter S, Tetaz TJ, Berndt MC, Ashman LK (1995). "Molecular cloning of cDNA encoding a novel platelet-endothelial cell tetra-span antigen, PETA-3". Blood. 86 (4): 1348–55. doi:10.1182/blood.V86.4.1348.bloodjournal8641348. hdl:2440/103301. PMID 7632941.
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • Hasegawa H, Utsunomiya Y, Kishimoto K, Yanagisawa K, Fujita S (1996). "SFA-1, a novel cellular gene induced by human T-cell leukemia virus type 1, is a member of the transmembrane 4 superfamily". J. Virol. 70 (5): 3258–63. doi:10.1128/JVI.70.5.3258-3263.1996. PMC 190191. PMID 8627808.
  • Hasegawa H, Kishimoto K, Yanagisawa K, Terasaki H, Shimadzu M, Fujita S (1997). "Assignment of SFA-1 (PETA-3), a member of the transmembrane 4 superfamily, to human chromosome 11p15.5 by fluorescence in situ hybridization". Genomics. 40 (1): 193–6. doi:10.1006/geno.1996.4563. PMID 9070943.
  • Sincock PM, Mayrhofer G, Ashman LK (1997). "Localization of the transmembrane 4 superfamily (TM4SF) member PETA-3 (CD151) in normal human tissues: comparison with CD9, CD63, and alpha5beta1 integrin". J. Histochem. Cytochem. 45 (4): 515–25. doi:10.1177/002215549704500404. PMID 9111230.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Fitter S, Seldin MF, Ashman LK (1998). "Characterisation of the mouse homologue of CD151 (PETA-3/SFA-1); genomic structure, chromosomal localisation and identification of 2 novel splice forms". Biochim. Biophys. Acta. 1398 (1): 75–85. doi:10.1016/S0167-4781(98)00034-7. PMID 9602068.
  • Sincock PM, Fitter S, Parton RG, Berndt MC, Gamble JR, Ashman LK (1999). "PETA-3/CD151, a member of the transmembrane 4 superfamily, is localised to the plasma membrane and endocytic system of endothelial cells, associates with multiple integrins and modulates cell function". J. Cell Sci. 112 ( Pt 6) (6): 833–44. doi:10.1242/jcs.112.6.833. hdl:2440/8940. PMID 10036233.
  • Serru V, Le Naour F, Billard M, Azorsa DO, Lanza F, Boucheix C, Rubinstein E (1999). "Selective tetraspan-integrin complexes (CD81/alpha4beta1, CD151/alpha3beta1, CD151/alpha6beta1) under conditions disrupting tetraspan interactions". Biochem. J. 340 (1): 103–11. doi:10.1042/0264-6021:3400103. PMC 1220227. PMID 10229664.
  • Testa JE, Brooks PC, Lin JM, Quigley JP (1999). "Eukaryotic expression cloning with an antimetastatic monoclonal antibody identifies a tetraspanin (PETA-3/CD151) as an effector of human tumor cell migration and metastasis". Cancer Res. 59 (15): 3812–20. PMID 10447000.
  • Sterk LM, Geuijen CA, Oomen LC, Calafat J, Janssen H, Sonnenberg A (2000). "The tetraspan molecule CD151, a novel constituent of hemidesmosomes, associates with the integrin alpha6beta4 and may regulate the spatial organization of hemidesmosomes". J. Cell Biol. 149 (4): 969–82. doi:10.1083/jcb.149.4.969. PMC 2174566. PMID 10811835.
  • Whittock NV, McLean WH (2001). "Genomic organization, amplification, fine mapping, and intragenic polymorphisms of the human hemidesmosomal tetraspanin CD151 gene". Biochem. Biophys. Res. Commun. 281 (2): 425–30. doi:10.1006/bbrc.2001.4384. PMID 11181065.
  • Charrin S, Le Naour F, Oualid M, Billard M, Faure G, Hanash SM, Boucheix C, Rubinstein E (2001). "The major CD9 and CD81 molecular partner. Identification and characterization of the complexes". J. Biol. Chem. 276 (17): 14329–37. doi:10.1074/jbc.M011297200. PMID 11278880.
  • Suzuki Y, Tsunoda T, Sese J, Taira H, Mizushima-Sugano J, Hata H, Ota T, Isogai T, Tanaka T, Nakamura Y, Suyama A, Sakaki Y, Morishita S, Okubo K, Sugano S (2001). "Identification and characterization of the potential promoter regions of 1031 kinds of human genes". Genome Res. 11 (5): 677–84. doi:10.1101/gr.gr-1640r. PMC 311086. PMID 11337467.
  • Kohno M, Hasegawa H, Miyake M, Yamamoto T, Fujita S (2002). "CD151 enhances cell motility and metastasis of cancer cells in the presence of focal adhesion kinase". Int. J. Cancer. 97 (3): 336–43. doi:10.1002/ijc.1605. PMID 11774285. S2CID 46569418.
  • Zhang XA, Kazarov AR, Yang X, Bontrager AL, Stipp CS, Hemler ME (2002). "Function of the tetraspanin CD151-alpha6beta1 integrin complex during cellular morphogenesis". Mol. Biol. Cell. 13 (1): 1–11. doi:10.1091/mbc.01-10-0481. PMC 65068. PMID 11809818.

External links

  • Raph blood group system in the BGMUT blood group antigen gene mutation database
  • Human CD151 genome location and CD151 gene details page in the UCSC Genome Browser.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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Arrestin
Membrane-spanning 4A
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see also other cell membrane protein disorders


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