CENPN

Protein-coding gene in the species Homo sapiens
CENPN
Identifiers
AliasesCENPN, BM039, C16orf60, CENP-N, ICEN32, centromere protein N
External IDsOMIM: 611509 MGI: 1919405 HomoloGene: 12450 GeneCards: CENPN
Gene location (Human)
Chromosome 16 (human)
Chr.Chromosome 16 (human)[1]
Chromosome 16 (human)
Genomic location for CENPN
Genomic location for CENPN
Band16q23.2Start81,006,552 bp[1]
End81,033,114 bp[1]
Gene location (Mouse)
Chromosome 8 (mouse)
Chr.Chromosome 8 (mouse)[2]
Chromosome 8 (mouse)
Genomic location for CENPN
Genomic location for CENPN
Band8|8 E1Start117,648,469 bp[2]
End117,668,246 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • ganglionic eminence

  • secondary oocyte

  • bone marrow

  • stromal cell of endometrium

  • sperm

  • trabecular bone

  • bone marrow cells

  • prostate

  • testicle

  • amniotic fluid
Top expressed in
  • secondary oocyte

  • seminiferous tubule

  • spermatid

  • spermatocyte

  • yolk sac

  • primitive streak

  • blastocyst

  • morula

  • maxillary prominence

  • otic placode
More reference expression data
BioGPS


More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

55839

72155

Ensembl

ENSG00000166451

ENSMUSG00000031756

UniProt

Q96H22

Q9CZW2

RefSeq (mRNA)

NM_001100624
NM_001100625
NM_001270473
NM_001270474
NM_018455

NM_028131

RefSeq (protein)

NP_001094094
NP_001094095
NP_001257402
NP_001257403
NP_060925

NP_082407

Location (UCSC)Chr 16: 81.01 – 81.03 MbChr 8: 117.65 – 117.67 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Centromere protein N is a protein that in humans is encoded by the CENPN gene.[5][6]


References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000166451 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000031756 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Foltz DR, Jansen LE, Black BE, Bailey AO, Yates JR 3rd, Cleveland DW (May 2006). "The human CENP-A centromeric nucleosome-associated complex". Nat Cell Biol. 8 (5): 458–69. doi:10.1038/ncb1397. PMID 16622419. S2CID 205286556.
  6. ^ "Entrez Gene: CENPN centromere protein N".

External links

Further reading

  • Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
  • Izuta H, Ikeno M, Suzuki N, et al. (2006). "Comprehensive analysis of the ICEN (Interphase Centromere Complex) components enriched in the CENP-A chromatin of human cells". Genes Cells. 11 (6): 673–84. doi:10.1111/j.1365-2443.2006.00969.x. PMID 16716197. S2CID 45931410.
  • Okada M, Cheeseman IM, Hori T, et al. (2006). "The CENP-H-I complex is required for the efficient incorporation of newly synthesized CENP-A into centromeres". Nat. Cell Biol. 8 (5): 446–57. doi:10.1038/ncb1396. PMID 16622420. S2CID 26974412.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Obuse C, Yang H, Nozaki N, et al. (2004). "Proteomics analysis of the centromere complex from HeLa interphase cells: UV-damaged DNA binding protein 1 (DDB-1) is a component of the CEN-complex, while BMI-1 is transiently co-localized with the centromeric region in interphase". Genes Cells. 9 (2): 105–20. doi:10.1111/j.1365-2443.2004.00705.x. PMID 15009096. S2CID 21813024.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.


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