CHMP4B

Protein-coding gene in the species Homo sapiens
CHMP4B
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

3C3Q, 3UM3, 4ABM

Identifiers
AliasesCHMP4B, C20orf178, CHMP4A, CTPP3, CTRCT31, SNF7, SNF7-2, Shax1, VPS32B, Vps32-2, dJ553F4.4, charged multivesicular body protein 4B
External IDsOMIM: 610897; MGI: 1922858; HomoloGene: 57102; GeneCards: CHMP4B; OMA:CHMP4B - orthologs
Gene location (Human)
Chromosome 20 (human)
Chr.Chromosome 20 (human)[1]
Chromosome 20 (human)
Genomic location for CHMP4B
Genomic location for CHMP4B
Band20q11.22Start33,811,348 bp[1]
End33,854,366 bp[1]
Gene location (Mouse)
Chromosome 2 (mouse)
Chr.Chromosome 2 (mouse)[2]
Chromosome 2 (mouse)
Genomic location for CHMP4B
Genomic location for CHMP4B
Band2|2 H1Start154,493,625 bp[2]
End154,536,705 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • mucosa of ileum

  • skin of arm

  • tibialis anterior muscle

  • nasal epithelium

  • mucosa of transverse colon

  • cartilage tissue

  • cardiac muscle tissue of right atrium

  • muscle layer of sigmoid colon

  • gastric mucosa

  • tibial arteries
Top expressed in
  • vestibular membrane of cochlear duct

  • Ileal epithelium

  • Epithelium of choroid plexus

  • transitional epithelium of urinary bladder

  • conjunctival fornix

  • substantia nigra

  • facial motor nucleus

  • anterior horn of spinal cord

  • iris

  • motor neuron
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • protein homodimerization activity
  • protein binding
  • identical protein binding
  • cadherin binding
Cellular component
  • cytoplasm
  • ESCRT III complex
  • cytosol
  • endosome
  • membrane
  • late endosome membrane
  • cytoplasmic side of plasma membrane
  • membrane coat
  • extracellular exosome
  • vesicle
  • midbody
  • nuclear envelope
  • nucleus
Biological process
  • negative regulation of autophagosome assembly
  • regulation of centrosome duplication
  • viral life cycle
  • nucleus organization
  • maintenance of lens transparency
  • multivesicular body assembly
  • negative regulation of cell death
  • regulation of mitotic spindle assembly
  • autophagy
  • endosomal transport
  • posttranslational protein targeting to endoplasmic reticulum membrane
  • ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway
  • protein transport
  • septum digestion after cytokinesis
  • mitotic metaphase plate congression
  • protein homooligomerization
  • vacuolar transport
  • negative regulation of neuron death
  • nuclear membrane reassembly
  • exit from mitosis
  • mitotic cytokinesis
  • regulation of autophagy
  • membrane fission
  • macroautophagy
  • transport
  • viral budding via host ESCRT complex
  • midbody abscission
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

128866

75608

Ensembl

ENSG00000101421

ENSMUSG00000038467

UniProt

Q9H444

Q9D8B3

RefSeq (mRNA)

NM_176812

NM_029362

RefSeq (protein)

NP_789782

NP_083638

Location (UCSC)Chr 20: 33.81 – 33.85 MbChr 2: 154.49 – 154.54 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Charged multivesicular body protein 4b is a protein that in humans is encoded by the CHMP4B gene.[5][6]


References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000101421 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000038467 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Katoh K, Shibata H, Hatta K, Maki M (Dec 2003). "CHMP4b is a major binding partner of the ALG-2-interacting protein Alix among the three CHMP4 isoforms". Arch Biochem Biophys. 421 (1): 159–65. doi:10.1016/j.abb.2003.09.038. PMID 14678797.
  6. ^ "Entrez Gene: CHMP4B chromatin modifying protein 4B".

External links

Further reading

  • Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. Bibcode:2001Natur.414..865D. doi:10.1038/414865a. PMID 11780052.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Katoh K, Shibata H, Suzuki H, et al. (2003). "The ALG-2-interacting protein Alix associates with CHMP4b, a human homologue of yeast Snf7 that is involved in multivesicular body sorting". J. Biol. Chem. 278 (40): 39104–13. doi:10.1074/jbc.M301604200. PMID 12860994.
  • Strack B, Calistri A, Craig S, et al. (2003). "AIP1/ALIX is a binding partner for HIV-1 p6 and EIAV p9 functioning in virus budding". Cell. 114 (6): 689–99. doi:10.1016/S0092-8674(03)00653-6. PMID 14505569. S2CID 10733770.
  • von Schwedler UK, Stuchell M, Müller B, et al. (2003). "The protein network of HIV budding". Cell. 114 (6): 701–13. doi:10.1016/S0092-8674(03)00714-1. PMID 14505570. S2CID 16894972.
  • Martin-Serrano J, Yarovoy A, Perez-Caballero D, et al. (2003). "Divergent retroviral late-budding domains recruit vacuolar protein sorting factors by using alternative adaptor proteins". Proc. Natl. Acad. Sci. U.S.A. 100 (21): 12414–9. Bibcode:2003PNAS..10012414M. doi:10.1073/pnas.2133846100. PMC 218772. PMID 14519844.
  • Peck JW, Bowden ET, Burbelo PD (2004). "Structure and function of human Vps20 and Snf7 proteins". Biochem. J. 377 (Pt 3): 693–700. doi:10.1042/BJ20031347. PMC 1223912. PMID 14583093.
  • Sharma M, Pampinella F, Nemes C, et al. (2004). "Misfolding diverts CFTR from recycling to degradation: quality control at early endosomes". J. Cell Biol. 164 (6): 923–33. doi:10.1083/jcb.200312018. PMC 2172283. PMID 15007060.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Yorikawa C, Shibata H, Waguri S, et al. (2005). "Human CHMP6, a myristoylated ESCRT-III protein, interacts directly with an ESCRT-II component EAP20 and regulates endosomal cargo sorting". Biochem. J. 387 (Pt 1): 17–26. doi:10.1042/BJ20041227. PMC 1134928. PMID 15511219.
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
  • Tsang HT, Connell JW, Brown SE, et al. (2006). "A systematic analysis of human CHMP protein interactions: additional MIT domain-containing proteins bind to multiple components of the human ESCRT III complex". Genomics. 88 (3): 333–46. doi:10.1016/j.ygeno.2006.04.003. PMID 16730941.
  • Usami Y, Popov S, Göttlinger HG (2007). "Potent Rescue of Human Immunodeficiency Virus Type 1 Late Domain Mutants by ALIX/AIP1 Depends on Its CHMP4 Binding Site". J. Virol. 81 (12): 6614–22. doi:10.1128/JVI.00314-07. PMC 1900090. PMID 17428861.
  • Shiels A, Bennett TM, Knopf HL, et al. (2007). "CHMP4B, a Novel Gene for Autosomal Dominant Cataracts Linked to Chromosome 20q". Am. J. Hum. Genet. 81 (3): 596–606. doi:10.1086/519980. PMC 1950844. PMID 17701905.


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