Protein-coding gene in the species Homo sapiens
| CHRNA2 |
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| Identifiers |
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| Aliases | CHRNA2, cholinergic receptor nicotinic alpha 2 subunit |
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| External IDs | OMIM: 118502 MGI: 87886 HomoloGene: 20193 GeneCards: CHRNA2 |
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| Gene location (Human) |
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 | | Chr. | Chromosome 8 (human)[1] |
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| | Band | 8p21.2 | Start | 27,459,756 bp[1] |
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| End | 27,479,883 bp[1] |
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| Gene location (Mouse) |
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 | | Chr. | Chromosome 14 (mouse)[2] |
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| | Band | 14 D1|14 34.36 cM | Start | 66,372,488 bp[2] |
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| End | 66,390,397 bp[2] |
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| RNA expression pattern |
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| Bgee | | Human | Mouse (ortholog) |
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| Top expressed in | - secondary oocyte
- prostate
- prefrontal cortex
- inferior ganglion of vagus nerve
- periodontal fiber
- renal medulla
- bone
- bone marrow
- monocyte
- corpus epididymis
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| | Top expressed in | - proximal tubule
- superior frontal gyrus
- thoracic diaphragm
- cerebellar cortex
- liver
- white adipose tissue
- olfactory bulb
- muscle tissue
- striated muscle tissue
- skeletal muscle tissue
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| | More reference expression data |
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| BioGPS |  | | More reference expression data |
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| Gene ontology |
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| Molecular function | - acetylcholine binding
- acetylcholine receptor activity
- ion channel activity
- extracellular ligand-gated ion channel activity
- ligand-gated ion channel activity
- acetylcholine-gated cation-selective channel activity
- transmembrane signaling receptor activity
| | Cellular component | - integral component of membrane
- acetylcholine-gated channel complex
- postsynaptic membrane
- membrane
- plasma membrane
- synapse
- cell junction
- cell periphery
- integral component of plasma membrane
- neuron projection
| | Biological process | - protein heterooligomerization
- response to nicotine
- synaptic transmission, cholinergic
- ion transport
- neuromuscular synaptic transmission
- signal transduction
- regulation of postsynaptic membrane potential
- excitatory postsynaptic potential
- ion transmembrane transport
- chemical synaptic transmission
- regulation of membrane potential
- nervous system process
- transmembrane transport
| | Sources:Amigo / QuickGO |
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| Orthologs |
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| Species | Human | Mouse |
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| Entrez | | |
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| Ensembl | | |
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| UniProt | | |
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| RefSeq (mRNA) | NM_000742
NM_001282455
NM_001347705
NM_001347706
NM_001347707
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NM_001347708 |
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| RefSeq (protein) | NP_000733
NP_001269384
NP_001334634
NP_001334635
NP_001334636
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NP_001334637 |
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| Location (UCSC) | Chr 8: 27.46 – 27.48 Mb | Chr 14: 66.37 – 66.39 Mb |
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| PubMed search | [3] | [4] |
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| Wikidata |
| View/Edit Human | View/Edit Mouse |
|
Neuronal acetylcholine receptor subunit alpha-2, also known as nAChRα2, is a protein that in humans is encoded by the CHRNA2 gene.[5][6] The protein encoded by this gene is a subunit of certain nicotinic acetylcholine receptors (nAchR).
Function
Knockout of this gene in mice potentiates nicotine-modulated behaviors.[7] Using two different genetically modified mutant mouse lines (Chrna2L9'S/L9'S and Chrna2KO), findings highlight that α2* nAChRs influence hippocampus-dependent learning and memory and CA1 synaptic plasticity in adolescent mice. [8]
See also
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000120903 - Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000022041 - Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Anand R, Lindstrom J (Sep 1992). "Chromosomal localization of seven neuronal nicotinic acetylcholine receptor subunit genes in humans". Genomics. 13 (4): 962–7. doi:10.1016/0888-7543(92)90008-G. PMID 1505988.
- ^ "Entrez Gene: CHRNA2 cholinergic receptor, nicotinic, alpha 2 (neuronal)".
- ^ Lotfipour S, Byun JS, Leach P, Fowler CD, Murphy NP, Kenny PJ, Gould TJ, Boulter J (May 2013). "Targeted Deletion of the Mouse α2 Nicotinic Acetylcholine Receptor Subunit Gene (Chrna2) Potentiates Nicotine-Modulated Behaviors". J. Neurosci. 33 (18): 7728–41. doi:10.1523/JNEUROSCI.4731-12.2013. PMC 3831006. PMID 23637165.
- ^ Lotfipour S, Mojica C, Nakauchi S, Lipovsek M, Silverstein S, Cushman J, Tirtorahardjo J, Poulos A, Elgoyhen AB, Sumikawa K, Fanselow MS, Boulter J (May 2017). "α2* Nicotinic acetylcholine receptors influence hippocampus-dependent learning and memory in adolescent mice". Learn Mem. 24 (6): 231–244. doi:10.1101/lm.045369.117. PMC 5435881. PMID 28507032.
Further reading
- Hogg RC, Raggenbass M, Bertrand D (2003). "Nicotinic acetylcholine receptors: from structure to brain function". Rev. Physiol. Biochem. Pharmacol. Reviews of Physiology, Biochemistry and Pharmacology. 147: 1–46. doi:10.1007/s10254-003-0005-1. ISBN 978-3-540-01365-5. PMID 12783266.
- Wood S, Schertzer M, Yaremko ML (1995). "Identification of the human neuronal nicotinic cholinergic alpha 2 receptor locus, (CHRNA2), within an 8p21 mapped locus, by sequence homology with rat DNA". Somat. Cell Mol. Genet. 21 (2): 147–50. doi:10.1007/BF02255790. PMID 7570187. S2CID 28611125.
- García-Colunga J, Miledi R (1995). "Effects of serotonergic agents on neuronal nicotinic acetylcholine receptors". Proc. Natl. Acad. Sci. U.S.A. 92 (7): 2919–23. Bibcode:1995PNAS...92.2919G. doi:10.1073/pnas.92.7.2919. PMC 42330. PMID 7708749.
- Elliott KJ, Ellis SB, Berckhan KJ, et al. (1997). "Comparative structure of human neuronal alpha 2-alpha 7 and beta 2-beta 4 nicotinic acetylcholine receptor subunits and functional expression of the alpha 2, alpha 3, alpha 4, alpha 7, beta 2, and beta 4 subunits". J. Mol. Neurosci. 7 (3): 217–28. doi:10.1007/BF02736842. PMID 8906617. S2CID 45737923.
- Chavez-Noriega LE, Crona JH, Washburn MS, et al. (1997). "Pharmacological characterization of recombinant human neuronal nicotinic acetylcholine receptors h alpha 2 beta 2, h alpha 2 beta 4, h alpha 3 beta 2, h alpha 3 beta 4, h alpha 4 beta 2, h alpha 4 beta 4 and h alpha 7 expressed in Xenopus oocytes". J. Pharmacol. Exp. Ther. 280 (1): 346–56. PMID 8996215.
- Navaneetham D, Penn A, Howard J, Conti-Fine BM (1997). "Expression of the alpha 7 subunit of the nicotinic acetylcholine receptor in normal and myasthenic human thymuses". Cell. Mol. Biol. (Noisy-le-grand). 43 (3): 433–42. PMID 9193799.
- Sato KZ, Fujii T, Watanabe Y, et al. (1999). "Diversity of mRNA expression for muscarinic acetylcholine receptor subtypes and neuronal nicotinic acetylcholine receptor subunits in human mononuclear leukocytes and leukemic cell lines". Neurosci. Lett. 266 (1): 17–20. doi:10.1016/S0304-3940(99)00259-1. PMID 10336173. S2CID 43548155.
- Bertrand D, Picard F, Le Hellard S, et al. (2002). "How mutations in the nAChRs can cause ADNFLE epilepsy". Epilepsia. 43 (Suppl 5): 112–22. doi:10.1046/j.1528-1157.43.s.5.16.x. PMID 12121305. S2CID 32858402.
- Jin P, Fu GK, Wilson AD, et al. (2004). "PCR isolation and cloning of novel splice variant mRNAs from known drug target genes". Genomics. 83 (4): 566–71. doi:10.1016/j.ygeno.2003.09.023. PMID 15028279.
- Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
- Nusbaum C, Mikkelsen TS, Zody MC, et al. (2006). "DNA sequence and analysis of human chromosome 8". Nature. 439 (7074): 331–5. Bibcode:2006Natur.439..331N. doi:10.1038/nature04406. PMID 16421571.
- Aridon P, Marini C, Di Resta C, et al. (2006). "Increased Sensitivity of the Neuronal Nicotinic Receptor α2 Subunit Causes Familial Epilepsy with Nocturnal Wandering and Ictal Fear". Am. J. Hum. Genet. 79 (2): 342–50. doi:10.1086/506459. PMC 1559502. PMID 16826524.
External links
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