Neuronal acetylcholine receptor subunit beta-2 is a protein that in humans is encoded by the CHRNB2gene.[5][6]
Neuronal acetylcholine receptors are homo- or heteropentameric complexes composed of homologous alpha and beta subunits. They belong to a superfamily of ligand-gated ion channels which allow the flow of sodium and potassium across the plasma membrane in response to ligands such as acetylcholine and nicotine. This gene encodes one of several beta subunits. Mutations in this gene are associated with autosomal dominant nocturnal frontal lobe epilepsy.[6]
It has been discovered that suppression, rather than stimulation, of B2-containing nAChR currents yields an antidepressant effect. This is believed to explain the significantly increased prevalence of cigarette smoking in depressed individuals and the profound rise in depressive symptoms during abstinence.
Interactive pathway map
Click on genes, proteins and metabolites below to link to respective articles.[§ 1]
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|alt=Nicotine Activity on Dopaminergic Neurons edit]]
Nicotine Activity on Dopaminergic Neurons edit
^The interactive pathway map can be edited at WikiPathways: "NicotineDopaminergic_WP1602".
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Engidawork E, Gulesserian T, Balic N, et al. (2002). "Changes in nicotinic acetylcholine receptor subunits expression in brain of patients with Down syndrome and Alzheimer's disease". Protein Expression in Down Syndrome Brain. pp. 211–22. doi:10.1007/978-3-7091-6262-0_17. ISBN 978-3-211-83704-7. PMID 11771745. {{cite book}}: |journal= ignored (help)
Lueders KK, Hu S, McHugh L, et al. (2002). "Genetic and functional analysis of single nucleotide polymorphisms in the beta2-neuronal nicotinic acetylcholine receptor gene (CHRNB2)". Nicotine Tob. Res. 4 (1): 115–25. doi:10.1080/14622200110098419. PMID 11906688.
Duga S, Asselta R, Bonati MT, et al. (2002). "Mutational analysis of nicotinic acetylcholine receptor beta2 subunit gene (CHRNB2) in a representative cohort of Italian probands affected by autosomal dominant nocturnal frontal lobe epilepsy". Epilepsia. 43 (4): 362–4. doi:10.1046/j.1528-1157.2002.39001.x. PMID 11952766. S2CID 34970690.
Heeschen C, Weis M, Aicher A, et al. (2002). "A novel angiogenic pathway mediated by non-neuronal nicotinic acetylcholine receptors". J. Clin. Invest. 110 (4): 527–36. doi:10.1172/JCI14676. PMC 150415. PMID 12189247.
Lin L, Jeanclos EM, Treuil M, et al. (2003). "The calcium sensor protein visinin-like protein-1 modulates the surface expression and agonist sensitivity of the alpha 4beta 2 nicotinic acetylcholine receptor". J. Biol. Chem. 277 (44): 41872–8. doi:10.1074/jbc.M206857200. PMID 12202488.
Kawamata J, Shimohama S (2002). "Association of novel and established polymorphisms in neuronal nicotinic acetylcholine receptors with sporadic Alzheimer's disease". J. Alzheimers Dis. 4 (2): 71–6. doi:10.3233/JAD-2002-4201. hdl:2433/149693. PMID 12214130.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
