CLCA4

Protein-coding gene in the species Homo sapiens
CLCA4
Identifiers
AliasesCLCA4, CaCC, CaCC2, chloride channel accessory 4
External IDsOMIM: 616857 MGI: 2139744 HomoloGene: 40808 GeneCards: CLCA4
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for CLCA4
Genomic location for CLCA4
Band1p22.3Start86,547,078 bp[1]
End86,580,754 bp[1]
Gene location (Mouse)
Chromosome 3 (mouse)
Chr.Chromosome 3 (mouse)[2]
Chromosome 3 (mouse)
Genomic location for CLCA4
Genomic location for CLCA4
Band3|3 H2Start144,658,241 bp[2]
End144,680,806 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • oral cavity

  • rectum

  • cervix epithelium

  • mucosa of urinary bladder

  • vulva

  • gums

  • body of tongue

  • periodontal fiber

  • appendix

  • vagina
Top expressed in
  • jejunum

  • Paneth cell

  • left colon

  • ileum

  • duodenum

  • conjunctival fornix

  • cornea

  • ciliary body

  • esophagus

  • stomach
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • peptidase activity
  • hydrolase activity
  • metallopeptidase activity
  • metal ion binding
  • chloride channel activity
  • metalloendopeptidase activity
  • intracellular calcium activated chloride channel activity
Cellular component
  • integral component of membrane
  • extracellular region
  • plasma membrane
  • integral component of plasma membrane
  • apical plasma membrane
  • membrane
Biological process
  • ion transmembrane transport
  • chloride transport
  • proteolysis
  • chloride transmembrane transport
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

22802

99663

Ensembl

ENSG00000016602

ENSMUSG00000068547

UniProt

Q14CN2

Q6Q473

RefSeq (mRNA)

NM_012128

NM_207208

RefSeq (protein)

NP_036260

NP_997091

Location (UCSC)Chr 1: 86.55 – 86.58 MbChr 3: 144.66 – 144.68 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Chloride channel accessory 4, also known as CLCA4, is a protein which in humans CLCA4 gene. The protein encoded by this gene is a chloride channel.[5] Protein structure prediction methods suggest the N-terminal region of CLCA4 protein is a zinc metalloprotease, and the protein is not an ion channel per se.[6]

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000016602 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000068547 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Agnel M, Vermat T, Culouscou JM (July 1999). "Identification of three novel members of the calcium-dependent chloride channel (CaCC) family predominantly expressed in the digestive tract and trachea". FEBS Lett. 455 (3): 295–301. doi:10.1016/S0014-5793(99)00891-1. PMID 10437792. S2CID 82094058.
  6. ^ Pawłowski K, Lepistö M, Meinander N, et al. (2006). "Novel conserved hydrolase domain in the CLCA family of alleged calcium-activated chloride channels". Proteins. 63 (3): 424–39. doi:10.1002/prot.20887. PMID 16470849. S2CID 40041491.

Further reading

  • Liu QH, Williams DA, McManus C, et al. (2000). "HIV-1 gp120 and chemokines activate ion channels in primary macrophages through CCR5 and CXCR4 stimulation". Proc. Natl. Acad. Sci. U.S.A. 97 (9): 4832–7. Bibcode:2000PNAS...97.4832L. doi:10.1073/pnas.090521697. PMC 18318. PMID 10758170.
  • Ritzka M, Stanke F, Jansen S, et al. (2004). "The CLCA gene locus as a modulator of the gastrointestinal basic defect in cystic fibrosis". Hum. Genet. 115 (6): 483–91. doi:10.1007/s00439-004-1190-y. PMID 15490240. S2CID 12935280.
  • Bonaldo MF, Lennon G, Soares MB (1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
  • Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
  • Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Pauli BU, Abdel-Ghany M, Cheng HC, et al. (2000). "Molecular characteristics and functional diversity of CLCA family members". Clin. Exp. Pharmacol. Physiol. 27 (11): 901–5. doi:10.1046/j.1440-1681.2000.03358.x. PMID 11071307. S2CID 28762005.

External links

  • v
  • t
  • e
Ligand-gated
Voltage-gated
Constitutively active
Proton-gated
Voltage-gated
Calcium-activated
Inward-rectifier
Tandem pore domain
Voltage-gated
Miscellaneous
Cl−: Chloride channel
H+: Proton channel
M+: CNG cation channel
M+: TRP cation channel
H2O (+ solutes): Porin
Cytoplasm: Gap junction
By gating mechanism
Ion channel class
see also disorders


Stub icon

This membrane protein–related article is a stub. You can help Wikipedia by expanding it.

  • v
  • t
  • e