CNOT11

Protein-coding gene in the species Homo sapiens
CNOT11
Identifiers
AliasesCNOT11, C2orf29, C40, CCR4-NOT transcription complex subunit 11
External IDsMGI: 106580; HomoloGene: 9711; GeneCards: CNOT11; OMA:CNOT11 - orthologs
Gene location (Human)
Chromosome 2 (human)
Chr.Chromosome 2 (human)[1]
Chromosome 2 (human)
Genomic location for CNOT11
Genomic location for CNOT11
Band2q11.2Start101,252,886 bp[1]
End101,270,316 bp[1]
Gene location (Mouse)
Chromosome 1 (mouse)
Chr.Chromosome 1 (mouse)[2]
Chromosome 1 (mouse)
Genomic location for CNOT11
Genomic location for CNOT11
Band1 B|1 18.31 cMStart39,574,073 bp[2]
End39,585,970 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • oocyte

  • secondary oocyte

  • mucosa of ileum

  • myocardium of left ventricle

  • tibialis anterior muscle

  • rectum

  • body of pancreas

  • mucosa of transverse colon

  • cardiac muscle tissue of right atrium

  • granulocyte
Top expressed in
  • primary oocyte

  • secondary oocyte

  • hand

  • epiblast

  • spermatocyte

  • zygote

  • interventricular septum

  • superior cervical ganglion

  • endocardial cushion

  • Gonadal ridge
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • protein binding
  • molecular function
Cellular component
  • cytoplasm
  • cytosol
  • nucleus
  • CCR4-NOT complex
Biological process
  • nuclear-transcribed mRNA poly(A) tail shortening
  • gene silencing
  • cell population proliferation
  • regulation of transcription, DNA-templated
  • regulation of translation
  • transcription, DNA-templated
  • DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

55571

52846

Ensembl

ENSG00000158435

ENSMUSG00000003135

UniProt

Q9UKZ1

Q9CWN7

RefSeq (mRNA)

NM_017546

NM_028043

RefSeq (protein)

NP_060016

NP_082319

Location (UCSC)Chr 2: 101.25 – 101.27 MbChr 1: 39.57 – 39.59 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

CCR4-NOT transcription complex subunit 11 is a protein that in humans is encoded by the CNOT11 gene.[5] It is a subunit of the CCR4-Not deadenylase complex.


References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000158435 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000003135 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: CCR4-NOT transcription complex subunit 11". Retrieved 2020-04-15.

Further reading

  • Mauxion F, Prève B, Séraphin B (February 2013). "C2ORF29/CNOT11 and CNOT10 form a new module of the CCR4-NOT complex". RNA Biol. 10 (2): 267–76. doi:10.4161/rna.23065. PMC 3594285. PMID 23232451.


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