CNOT9

Protein-coding gene in the species Homo sapiens
CNOT9
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

2FV2, 4CRU, 4CRV, 4CT6, 4CT7

Identifiers
AliasesCNOT9, CT129, RCD-1, RCD1, CAF40, RQCD1, CCR4-NOT transcription complex subunit 9
External IDsOMIM: 612054; MGI: 1928902; HomoloGene: 3973; GeneCards: CNOT9; OMA:CNOT9 - orthologs
Gene location (Human)
Chromosome 2 (human)
Chr.Chromosome 2 (human)[1]
Chromosome 2 (human)
Genomic location for CNOT9
Genomic location for CNOT9
Band2q35Start218,568,580 bp[1]
End218,597,080 bp[1]
Gene location (Mouse)
Chromosome 1 (mouse)
Chr.Chromosome 1 (mouse)[2]
Chromosome 1 (mouse)
Genomic location for CNOT9
Genomic location for CNOT9
Band1|1 C4Start74,545,217 bp[2]
End74,570,001 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • gingival epithelium

  • epithelium of nasopharynx

  • ganglionic eminence

  • right uterine tube

  • lymph node

  • stromal cell of endometrium

  • gastric mucosa

  • Achilles tendon

  • anterior pituitary

  • rectum
Top expressed in
  • tail of embryo

  • genital tubercle

  • yolk sac

  • epiblast

  • somite

  • ventricular zone

  • maxillary prominence

  • zygote

  • mandibular prominence

  • fetal liver hematopoietic progenitor cell
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • protein homodimerization activity
  • protein domain specific binding
  • protein binding
  • epidermal growth factor receptor binding
  • kinase binding
Cellular component
  • cytoplasm
  • cytosol
  • membrane
  • CCR4-NOT complex
  • P-body
  • CCR4-NOT core complex
  • nucleus
  • protein-containing complex
Biological process
  • nuclear-transcribed mRNA poly(A) tail shortening
  • negative regulation of translation
  • regulation of transcription, DNA-templated
  • mRNA catabolic process
  • cytokine-mediated signaling pathway
  • sex differentiation
  • transcription, DNA-templated
  • gene silencing
  • negative regulation of intracellular estrogen receptor signaling pathway
  • regulation of translation
  • DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
  • nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
  • positive regulation of peptidyl-serine phosphorylation
  • positive regulation of epidermal growth factor receptor signaling pathway
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

9125

58184

Ensembl

ENSG00000144580

ENSMUSG00000026174

UniProt

Q92600

Q9JKY0

RefSeq (mRNA)

NM_001271634
NM_001271635
NM_005444

NM_021383

RefSeq (protein)

NP_001258563
NP_001258564
NP_005435

NP_067358

Location (UCSC)Chr 2: 218.57 – 218.6 MbChr 1: 74.55 – 74.57 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

CCR4-NOT transcription complex subunit 9 is a protein that in humans is encoded by the CNOT9 gene. [5]

Function

This gene encodes a member of the highly conserved RCD1 protein family. The encoded protein is a transcriptional cofactor and a core protein of the CCR4-Not deadenylation complex. It may be involved in signal transduction as well as retinoic acid-regulated cell differentiation and development. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Oct 2012].

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000144580 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000026174 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: CCR4-NOT transcription complex subunit 9". Retrieved 2020-04-15.

Further reading

  • Hiroi N, Ito T, Yamamoto H, Ochiya T, Jinno S, Okayama H (October 2002). "Mammalian Rcd1 is a novel transcriptional cofactor that mediates retinoic acid-induced cell differentiation". EMBO J. 21 (19): 5235–44. doi:10.1093/emboj/cdf521. PMC 129043. PMID 12356739.
  • Garapaty S, Mahajan MA, Samuels HH (March 2008). "Components of the CCR4-NOT complex function as nuclear hormone receptor coactivators via association with the NRC-interacting Factor NIF-1". J. Biol. Chem. 283 (11): 6806–16. doi:10.1074/jbc.M706986200. PMID 18180299.
  • Ajiro M, Katagiri T, Ueda K, Nakagawa H, Fukukawa C, Lin ML, Park JH, Nishidate T, Daigo Y, Nakamura Y (October 2009). "Involvement of RQCD1 overexpression, a novel cancer-testis antigen, in the Akt pathway in breast cancer cells". Int. J. Oncol. 35 (4): 673–81. PMID 19724902.
  • Ajiro M, Nishidate T, Katagiri T, Nakamura Y (November 2010). "Critical involvement of RQCD1 in the EGFR-Akt pathway in mammary carcinogenesis". Int. J. Oncol. 37 (5): 1085–93. doi:10.3892/ijo_00000760. PMID 20878056.
  • Mathys H, Basquin J, Ozgur S, Czarnocki-Cieciura M, Bonneau F, Aartse A, Dziembowski A, Nowotny M, Conti E, Filipowicz W (June 2014). "Structural and biochemical insights to the role of the CCR4-NOT complex and DDX6 ATPase in microRNA repression". Mol. Cell. 54 (5): 751–65. doi:10.1016/j.molcel.2014.03.036. PMID 24768538.
  • Chen Y, Boland A, Kuzuoğlu-Öztürk D, Bawankar P, Loh B, Chang CT, Weichenrieder O, Izaurralde E (June 2014). "A DDX6-CNOT1 complex and W-binding pockets in CNOT9 reveal direct links between miRNA target recognition and silencing". Mol. Cell. 54 (5): 737–50. doi:10.1016/j.molcel.2014.03.034. PMID 24768540.
  • Wong SQ, Behren A, Mar VJ, Woods K, Li J, Martin C, Sheppard KE, Wolfe R, Kelly J, Cebon J, Dobrovic A, McArthur GA (January 2015). "Whole exome sequencing identifies a recurrent RQCD1 P131L mutation in cutaneous melanoma". Oncotarget. 6 (2): 1115–27. doi:10.18632/oncotarget.2747. PMC 4359221. PMID 25544760.
  • Bulbrook D, Brazier H, Mahajan P, Kliszczak M, Fedorov O, Marchese FP, Aubareda A, Chalk R, Picaud S, Strain-Damerell C, Filippakopoulos P, Gileadi O, Clark AR, Yue WW, Burgess-Brown NA, Dean JLE (March 2018). "Tryptophan-Mediated Interactions between Tristetraprolin and the CNOT9 Subunit Are Required for CCR4-NOT Deadenylase Complex Recruitment" (PDF). J. Mol. Biol. 430 (5): 722–736. doi:10.1016/j.jmb.2017.12.018. PMID 29291391.
  • Han J, Yu J, Dai Y, Li J, Guo M, Song J, Zhou X (February 2019). "Overexpression of miR-361-5p in triple-negative breast cancer (TNBC) inhibits migration and invasion by targeting RQCD1 and inhibiting the EGFR/PI3K/Akt pathway". Bosn J Basic Med Sci. 19 (1): 52–59. doi:10.17305/bjbms.2018.3399. PMC 6387672. PMID 29924958.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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