CPLX2

Protein-coding gene in humans

CPLX2

Identifiers

Aliases

CPLX2, 921-L, CPX-2, CPX2, Hfb1, complexin 2

External IDs

OMIM: 605033; MGI: 104726; HomoloGene: 38212; GeneCards: CPLX2; OMA:CPLX2 - orthologs

Gene location (Human)

Chr.	Chromosome 5 (human)^[1]

Band	5q35.2	Start	175,796,310 bp^[1]
Band	5q35.2	End	175,884,021 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 13 (mouse)^[2]

Band	13\|13 B1	Start	54,519,162 bp^[2]
Band	13\|13 B1	End	54,531,730 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

right hemisphere of cerebellum

right frontal lobe

amygdala

caudate nucleus

anterior cingulate cortex

dorsolateral prefrontal cortex

prefrontal cortex

nucleus accumbens

hippocampus proper

postcentral gyrus

Top expressed in

dentate gyrus of hippocampal formation granule cell

superior frontal gyrus

olfactory tubercle

cerebellar cortex

nucleus accumbens

globus pallidus

subiculum

cerebellar vermis

lobe of cerebellum

piriform cortex

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	syntaxin-1 binding syntaxin binding SNARE binding calcium-dependent protein binding
Cellular component	cytoplasm cytosol synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex mast cell granule synapse synaptobrevin 2-SNAP-25-syntaxin-3-complexin complex neuronal cell body dendrite SNARE complex presynapse calyx of Held postsynapse glutamatergic synapse terminal bouton
Biological process	cell differentiation synaptic vesicle exocytosis nervous system development positive regulation of synaptic plasticity vesicle docking involved in exocytosis regulation of exocytosis mast cell degranulation neurotransmitter transport exocytosis regulation of synaptic vesicle fusion to presynaptic active zone membrane regulation of neurotransmitter secretion
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


10814


12890

Ensembl


ENSG00000145920


ENSMUSG00000025867

UniProt


Q6PUV4


P84086

RefSeq (mRNA)


NM_001008220 NM_006650 NM_032282


NM_009946 NM_001362218

RefSeq (protein)


NP_001008221 NP_006641


NP_034076 NP_001349147

Location (UCSC)

Chr 5: 175.8 – 175.88 Mb

Chr 13: 54.52 – 54.53 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Complexin-2 is a protein that in humans is encoded by the CPLX2 gene.^[5]^[6]^[7]

Proteins encoded by the complexin/synaphin gene family are cytosolic proteins that function in synaptic vesicle exocytosis. These proteins bind syntaxin, part of the SNAP receptor. The protein product of this gene binds to the SNAP receptor complex and disrupts it, allowing transmitter release. Two transcript variants encoding the same protein have been found for this gene.^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000145920 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000025867 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ McMahon HT, Missler M, Li C, Sudhof TC (Nov 1995). "Complexins: cytosolic proteins that regulate SNAP receptor function". Cell. 83 (1): 111–9. doi:10.1016/0092-8674(95)90239-2. PMID 7553862. S2CID 675343.
^ Raevskaya NM, Dergunova LV, Vladychenskaya IP, Stavchansky VV, Oborina MV, Poltaraus AB, Limborska SA (Sep 2005). "Structural organization of the human complexin 2 gene (CPLX2) and aspects of its functional activity". Gene. 359: 127–37. doi:10.1016/j.gene.2005.07.005. PMID 16162394.
^ ^a ^b "Entrez Gene: CPLX2 complexin 2".

External links

Human CPLX2 genome location and CPLX2 gene details page in the UCSC Genome Browser.

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Morgans CW, Brandstätter JH, Kellerman J, et al. (1996). "A SNARE complex containing syntaxin 3 is present in ribbon synapses of the retina". J. Neurosci. 16 (21): 6713–21. doi:10.1523/JNEUROSCI.16-21-06713.1996. PMC 6579260. PMID 8824312.
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Pabst S, Margittai M, Vainius D, et al. (2002). "Rapid and selective binding to the synaptic SNARE complex suggests a modulatory role of complexins in neuroexocytosis". J. Biol. Chem. 277 (10): 7838–48. doi:10.1074/jbc.M109507200. hdl:11858/00-001M-0000-0012-F415-9. PMID 11751907.
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Edwardson JM, Wang CT, Gong B, et al. (2003). "Expression of mutant huntingtin blocks exocytosis in PC12 cells by depletion of complexin II". J. Biol. Chem. 278 (33): 30849–53. doi:10.1074/jbc.M304615200. PMID 12807877.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
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Eastwood SL, Harrison PJ (2005). "Decreased expression of vesicular glutamate transporter 1 and complexin II mRNAs in schizophrenia: further evidence for a synaptic pathology affecting glutamate neurons". Schizophr. Res. 73 (2–3): 159–72. doi:10.1016/j.schres.2004.05.010. PMID 15653259. S2CID 2335413.
DiProspero NA, Chen EY, Charles V, et al. (2005). "Early changes in Huntington's disease patient brains involve alterations in cytoskeletal and synaptic elements". J. Neurocytol. 33 (5): 517–33. doi:10.1007/s11068-004-0514-8. PMID 15906159. S2CID 20082165.