CRTC3

Protein-coding gene in the species Homo sapiens
CRTC3
Identifiers
AliasesCRTC3, TORC-3, TORC3, CREB regulated transcription coactivator 3
External IDsOMIM: 608986 MGI: 1917711 HomoloGene: 11248 GeneCards: CRTC3
Gene location (Human)
Chromosome 15 (human)
Chr.Chromosome 15 (human)[1]
Chromosome 15 (human)
Genomic location for CRTC3
Genomic location for CRTC3
Band15q26.1Start90,529,923 bp[1]
End90,645,345 bp[1]
Gene location (Mouse)
Chromosome 7 (mouse)
Chr.Chromosome 7 (mouse)[2]
Chromosome 7 (mouse)
Genomic location for CRTC3
Genomic location for CRTC3
Band7|7 D2- D3Start80,236,375 bp[2]
End80,338,625 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • endothelial cell

  • saphenous vein

  • parotid gland

  • visceral pleura

  • urethra

  • inferior olivary nucleus

  • parietal pleura

  • nipple

  • popliteal artery

  • inferior ganglion of vagus nerve
Top expressed in
  • internal carotid artery

  • external carotid artery

  • sciatic nerve

  • secondary oocyte

  • lacrimal gland

  • upper arm

  • ciliary body

  • iris

  • hair follicle

  • ankle
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • cAMP response element binding protein binding
  • protein binding
Cellular component
  • nucleus
  • nucleoplasm
  • cytoplasm
  • cytosol
Biological process
  • energy homeostasis
  • macrophage activation
  • positive regulation of CREB transcription factor activity
  • viral process
  • negative regulation of lipid catabolic process
  • regulation of transcription, DNA-templated
  • protein homotetramerization
  • negative regulation of cAMP-mediated signaling
  • transcription, DNA-templated
  • positive regulation of transcription by RNA polymerase II
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

64784

70461

Ensembl

ENSG00000140577

ENSMUSG00000030527

UniProt

Q6UUV7

Q91X84

RefSeq (mRNA)

NM_001042574
NM_022769

NM_173863

RefSeq (protein)

NP_001036039
NP_073606

NP_776288

Location (UCSC)Chr 15: 90.53 – 90.65 MbChr 7: 80.24 – 80.34 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

CREB-regulated transcription coactivator 3 is a protein that in humans is encoded by the CRTC3 gene.[5][6][7]

This gene has been shown to be linked to weight gain.[8]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000140577 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000030527 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Conkright MD, Canettieri G, Screaton R, Guzman E, Miraglia L, Hogenesch JB, Montminy M (Aug 2003). "TORCs: transducers of regulated CREB activity". Molecular Cell. 12 (2): 413–23. doi:10.1016/j.molcel.2003.08.013. PMID 14536081.
  6. ^ Iourgenko V, Zhang W, Mickanin C, Daly I, Jiang C, Hexham JM, Orth AP, Miraglia L, Meltzer J, Garza D, Chirn GW, McWhinnie E, Cohen D, Skelton J, Terry R, Yu Y, Bodian D, Buxton FP, Zhu J, Song C, Labow MA (Oct 2003). "Identification of a family of cAMP response element-binding protein coactivators by genome-scale functional analysis in mammalian cells". Proceedings of the National Academy of Sciences of the United States of America. 100 (21): 12147–52. doi:10.1073/pnas.1932773100. PMC 218727. PMID 14506290.
  7. ^ "Entrez Gene: CRTC3 CREB regulated transcription coactivator 3".
  8. ^ Song Y, Altarejos J, Goodarzi MO, Inoue H, Guo X, Berdeaux R, Kim JH, Goode J, Igata M, Paz JC, Hogan MF, Singh PK, Goebel N, Vera L, Miller N, Cui J, Jones MR, Chen YD, Taylor KD, Hsueh WA, Rotter JI, Montminy M (Dec 2010). "CRTC3 links catecholamine signalling to energy balance". Nature. 468 (7326): 933–939. Bibcode:2010Natur.468..933S. doi:10.1038/nature09564. PMC 3025711. PMID 21164481.

Further reading

  • Hishiki T, Ohshima T, Ego T, Shimotohno K (Sep 2007). "BCL3 acts as a negative regulator of transcription from the human T-cell leukemia virus type 1 long terminal repeat through interactions with TORC3". The Journal of Biological Chemistry. 282 (39): 28335–43. doi:10.1074/jbc.M702656200. PMID 17644518.
  • Wu Z, Huang X, Feng Y, Handschin C, Feng Y, Gullicksen PS, Bare O, Labow M, Spiegelman B, Stevenson SC (Sep 2006). "Transducer of regulated CREB-binding proteins (TORCs) induce PGC-1alpha transcription and mitochondrial biogenesis in muscle cells". Proceedings of the National Academy of Sciences of the United States of America. 103 (39): 14379–84. Bibcode:2006PNAS..10314379W. doi:10.1073/pnas.0606714103. PMC 1569674. PMID 16980408.
  • Koga H, Ohshima T, Shimotohno K (December 2004). "Enhanced activation of tax-dependent transcription of human T-cell leukemia virus type I (HTLV-I) long terminal repeat by TORC3". The Journal of Biological Chemistry. 279 (51): 52978–83. doi:10.1074/jbc.M409021200. PMID 15466468.
  • Jin J, Smith FD, Stark C, Wells CD, Fawcett JP, Kulkarni S, Metalnikov P, O'Donnell P, Taylor P, Taylor L, Zougman A, Woodgett JR, Langeberg LK, Scott JD, Pawson T (Aug 2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Current Biology. 14 (16): 1436–50. Bibcode:2004CBio...14.1436J. doi:10.1016/j.cub.2004.07.051. PMID 15324660.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (Oct 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Maruyama K, Sugano S (Jan 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.

External links

  • v
  • t
  • e
Coactivators
Corepressors
ATP-dependent remodeling factors
  • Chromatin Structure Remodeling (RSC) Complex
  • SWI/SNF


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