CWC15

Protein-coding gene in the species Homo sapiens
CWC15
Identifiers
AliasesCWC15, AD002, C11orf5, Cwf15, HSPC148, ORF5, CWC15 spliceosome-associated protein, CWC15 spliceosome associated protein homolog
External IDsMGI: 1913320; HomoloGene: 9499; GeneCards: CWC15; OMA:CWC15 - orthologs
Gene location (Human)
Chromosome 11 (human)
Chr.Chromosome 11 (human)[1]
Chromosome 11 (human)
Genomic location for CWC15
Genomic location for CWC15
Band11q21Start94,962,620 bp[1]
End94,973,586 bp[1]
Gene location (Mouse)
Chromosome 9 (mouse)
Chr.Chromosome 9 (mouse)[2]
Chromosome 9 (mouse)
Genomic location for CWC15
Genomic location for CWC15
Band9|9 A2Start14,411,913 bp[2]
End14,421,873 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • tibialis anterior muscle

  • cardiac muscle tissue of right atrium

  • myocardium of left ventricle

  • Skeletal muscle tissue of rectus abdominis

  • vastus lateralis muscle

  • biceps brachii

  • Skeletal muscle tissue of biceps brachii

  • body of tongue

  • muscle of thigh

  • left testis
Top expressed in
  • ventricular zone

  • neural layer of retina

  • muscle of thigh

  • morula

  • yolk sac

  • embryo

  • epiblast

  • embryo

  • tail of embryo

  • lip
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • protein binding
  • RNA binding
Cellular component
  • catalytic step 2 spliceosome
  • spliceosomal complex
  • nucleus
  • nucleoplasm
  • mitochondrion
  • nuclear speck
  • U2-type catalytic step 2 spliceosome
Biological process
  • mRNA processing
  • RNA splicing
  • mRNA splicing, via spliceosome
  • mRNA cis splicing, via spliceosome
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

51503

66070

Ensembl

ENSG00000150316

ENSMUSG00000004096

UniProt

Q9P013

Q9JHS9

RefSeq (mRNA)

NM_016403
NM_001363371
NM_001363372

NM_023153

RefSeq (protein)

NP_057487
NP_001350300
NP_001350301

NP_075642

Location (UCSC)Chr 11: 94.96 – 94.97 MbChr 9: 14.41 – 14.42 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Protein CWC15 homolog is a protein that in humans is encoded by the CWC15 gene.[5][6][7]


Interactions

CWC15 has been shown to interact with CDC5L.[8]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000150316 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000004096 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ O'Brien KP, Tapia-Paez I, Stahle-Backdahl M, Kedra D, Dumanski JP (Jul 2000). "Characterization of five novel human genes in the 11q13-q22 region". Biochem Biophys Res Commun. 273 (1): 90–4. doi:10.1006/bbrc.2000.2910. PMID 10873569.
  6. ^ Ohi MD, Link AJ, Ren L, Jennings JL, McDonald WH, Gould KL (Mar 2002). "Proteomics analysis reveals stable multiprotein complexes in both fission and budding yeasts containing Myb-related Cdc5p/Cef1p, novel pre-mRNA splicing factors, and snRNAs". Mol Cell Biol. 22 (7): 2011–24. doi:10.1128/MCB.22.7.2011-2024.2002. PMC 133674. PMID 11884590.
  7. ^ "Entrez Gene: HSPC148 hypothetical protein HSPC148".
  8. ^ Ajuh, P; Kuster B; Panov K; Zomerdijk J C; Mann M; Lamond A I (Dec 2000). "Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry". EMBO J. 19 (23): 6569–81. doi:10.1093/emboj/19.23.6569. ISSN 0261-4189. PMC 305846. PMID 11101529.

Further reading

  • Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.


  • v
  • t
  • e