CYP26C1

Protein-coding gene in the species Homo sapiens

CYP26C1

Identifiers

Aliases

CYP26C1, FFDD4, cytochrome P450 family 26 subfamily C member 1

External IDs

OMIM: 608428 MGI: 2679699 HomoloGene: 28089 GeneCards: CYP26C1

Gene location (Human)

Chr.	Chromosome 10 (human)^[1]

Band	10q23.33	Start	93,060,798 bp^[1]
Band	10q23.33	End	93,069,540 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 19 (mouse)^[2]

Band	19\|19 C2	Start	37,674,029 bp^[2]
Band	19\|19 C2	End	37,681,846 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

prefrontal cortex

placenta

spleen

myometrium

substantia nigra

hippocampus proper

hypothalamus

adrenal gland

Top expressed in

amnion

tongue

maxillary prominence

surface ectoderm

cochlea

lens

liver

rhombencephalon

More reference expression data

BioGPS

n/a

Gene ontology
Molecular function	iron ion binding oxidoreductase activity retinoic acid binding heme binding oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen metal ion binding monooxygenase activity retinoic acid 4-hydroxylase activity
Cellular component	integral component of membrane endoplasmic reticulum membrane membrane
Biological process	negative regulation of retinoic acid receptor signaling pathway central nervous system development retinoic acid catabolic process organelle fusion vitamin metabolic process neural crest cell development anterior/posterior pattern specification sterol metabolic process
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


340665


546726

Ensembl


ENSG00000187553


ENSMUSG00000062432

UniProt


Q6V0L0


B2RXA7

RefSeq (mRNA)


NM_183374


NM_001105201

RefSeq (protein)


NP_899230


NP_001098671

Location (UCSC)

Chr 10: 93.06 – 93.07 Mb

Chr 19: 37.67 – 37.68 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

CYP26C1 (cytochrome P450, family 26, subfamily c, polypeptide 1) is a protein which in humans is encoded by the CYP26C1 gene.^[5]

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This enzyme is involved in the catabolism of all-trans- and 9-cis-retinoic acid, and thus contributes to the regulation of retinoic acid levels in cells and tissues.^[6]

CYP26C1 was found to show no expression in colorectal cancer cells or normal colonic epithelium.^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000187553 - Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000062432 - Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Taimi M, Helvig C, Wisniewski J, et al. (January 2004). "A novel human cytochrome P450, CYP26C1, involved in metabolism of 9-cis and all-trans isomers of retinoic acid". J. Biol. Chem. 279 (1): 77–85. doi:10.1074/jbc.M308337200. PMID 14532297.
^ This article incorporates public domain material from "Entrez Gene: CYP26C1". Reference Sequence collection. National Center for Biotechnology Information.
^ Brown, Gordon; Beatriz Cash; Daniela Blihoghe; Petronella Johansson; Ayham Alnabulsi; Graeme Murray (2014-03-07). "The Expression and Prognostic Significance of Retinoic Acid Metabolising Enzymes in Colorectal Cancer". PLOS ONE. 9 (3): e90776. Bibcode:2014PLoSO...990776B. doi:10.1371/journal.pone.0090776. PMC 3946526. PMID 24608339.

External links

Human CYP26C1 genome location and CYP26C1 gene details page in the UCSC Genome Browser.

Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10". Nature. 429 (6990): 375–81. Bibcode:2004Natur.429..375D. doi:10.1038/nature02462. PMID 15164054.
Rat E, Billaut-Laden I, Allorge D, et al. (2006). "Evidence for a functional genetic polymorphism of the human retinoic acid-metabolizing enzyme CYP26A1, an enzyme that may be involved in spina bifida". Birth Defects Res. A. 76 (6): 491–8. doi:10.1002/bdra.20275. PMID 16933217.
Nelson DR, Zeldin DC, Hoffman SM, et al. (2004). "Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants". Pharmacogenetics. 14 (1): 1–18. doi:10.1097/00008571-200401000-00001. PMID 15128046.
Wan C, Shi Y, Zhao X, et al. (2009). "Positive association between ALDH1A2 and schizophrenia in the Chinese population". Prog. Neuropsychopharmacol. Biol. Psychiatry. 33 (8): 1491–5. doi:10.1016/j.pnpbp.2009.08.008. PMID 19703508. S2CID 32862839.
Grupe A, Li Y, Rowland C, et al. (2006). "A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease". Am. J. Hum. Genet. 78 (1): 78–88. doi:10.1086/498851. PMC 1380225. PMID 16385451.