CYP2W1

Protein-coding gene in the species Homo sapiens

CYP2W1

Identifiers

Aliases

CYP2W1, cytochrome P450 family 2 subfamily W member 1

External IDs

OMIM: 615967 MGI: 3616076 HomoloGene: 69239 GeneCards: CYP2W1

Gene location (Human)

Chr.	Chromosome 7 (human)^[1]

Band	7p22.3	Start	983,181 bp^[1]
Band	7p22.3	End	989,640 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 5 (mouse)^[2]

Band	5\|5 G2	Start	139,338,372 bp^[2]
Band	5\|5 G2	End	139,342,788 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

vena cava

skin of abdomen

internal globus pallidus

sural nerve

trabecular bone

amniotic fluid

pancreatic ductal cell

duodenum

body of tongue

nipple

Top expressed in

zone of skin

esophagus

ileum

colon

stomach

jejunum

limb

duodenum

neural tube

More reference expression data

BioGPS

n/a

Gene ontology
Molecular function	iron ion binding oxidoreductase activity heme binding oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen metal ion binding monooxygenase activity arachidonic acid epoxygenase activity steroid hydroxylase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
Cellular component	cell surface plasma membrane endoplasmic reticulum lumen endoplasmic reticulum membrane endoplasmic reticulum membrane cytoplasm intracellular membrane-bounded organelle
Biological process	xenobiotic metabolic process epoxygenase P450 pathway organic acid metabolic process
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


54905


545817

Ensembl


ENSG00000073067


ENSMUSG00000029541

UniProt


Q8TAV3


E9Q816

RefSeq (mRNA)


NM_017781


NM_001160265

RefSeq (protein)


NP_060251


NP_001153737

Location (UCSC)

Chr 7: 0.98 – 0.99 Mb

Chr 5: 139.34 – 139.34 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

CYP2W1 (cytochrome P450, family 2, subfamily W, polypeptide 1) is a protein that in humans is encoded by the CYP2W1 gene.^[5]

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids.^[6] CYP2W1 is an interesting enzyme since it is mainly expressed in tumors and not in normal human tissue.

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000073067 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000029541 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Gerhard DS, Wagner L, Feingold EA, et al. (October 2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
^ This article incorporates public domain material from "Entrez Gene: CYP2W1". Reference Sequence collection. National Center for Biotechnology Information.

External links

Human CYP2W1 genome location and CYP2W1 gene details page in the UCSC Genome Browser.

Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Hanzawa Y, Sasaki T, Mizugaki M, et al. (2008). "Genetic polymorphisms and haplotype structures of the human CYP2W1 gene in a Japanese population". Drug Metab. Dispos. 36 (2): 349–52. doi:10.1124/dmd.107.019141. PMID 17998294. S2CID 5123383.
Yoshioka H, Kasai N, Ikushiro S, et al. (2006). "Enzymatic properties of human CYP2W1 expressed in Escherichia coli". Biochem. Biophys. Res. Commun. 345 (1): 169–74. doi:10.1016/j.bbrc.2006.04.080. PMID 16677611.
Karlgren M, Gomez A, Stark K, et al. (2006). "Tumor-specific expression of the novel cytochrome P450 enzyme, CYP2W1". Biochem. Biophys. Res. Commun. 341 (2): 451–8. doi:10.1016/j.bbrc.2005.12.200. PMID 16426568.
Gomez A, Karlgren M, Edler D, et al. (2007). "Expression of CYP2W1 in colon tumors: regulation by gene methylation". Pharmacogenomics. 8 (10): 1315–25. doi:10.2217/14622416.8.10.1315. PMID 17979506.
Nelson DR, Zeldin DC, Hoffman SM, et al. (2004). "Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants". Pharmacogenetics. 14 (1): 1–18. doi:10.1097/00008571-200401000-00001. PMID 15128046.