CYP3A43

Protein-coding gene in the species Homo sapiens

CYP3A43

Available structures

PDB

Human UniProt search: PDBe RCSB

List of PDB id codes
1TQN, 1W0E, 1W0F, 1W0G, 2J0D, 2V0M, 3NXU, 3TJS, 3UA1, 4I3Q, 4I4G, 4I4H, 4K9T, 4K9U, 4K9V, 4K9W, 4K9X, 4NY4, 5A1P, 5A1R

Identifiers

Aliases

CYP3A43, cytochrome P450 family 3 subfamily A member 43

External IDs

OMIM: 606534 HomoloGene: 136124 GeneCards: CYP3A43

EC number

1.14.14.56

Gene location (Human)

Chr.	Chromosome 7 (human)^[1]

Band	7q22.1	Start	99,828,013 bp^[1]
Band	7q22.1	End	99,866,093 bp^[1]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

liver

right lobe of liver

body of pancreas

jejunal mucosa

sperm

skeletal muscle tissue

prostate

gastrocnemius muscle

testicle

pharynx

n/a

More reference expression data

BioGPS


More reference expression data

Orthologs

Species

Human

Mouse

Entrez


64816


n/a

Ensembl


ENSG00000021461


n/a

UniProt


Q9HB55


n/a

RefSeq (mRNA)


NM_001278921 NM_022820 NM_057095 NM_057096


n/a

RefSeq (protein)


NP_001265850 NP_073731 NP_476436 NP_476437


n/a

Location (UCSC)

Chr 7: 99.83 – 99.87 Mb

n/a

PubMed search

^[2]

n/a

Wikidata

View/Edit Human

Cytochrome P450 3A43 is a protein that in humans is encoded by the CYP3A43 gene.^[3]^[4]^[5]

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This enzyme has a low level of testosterone hydroxylase activity. Although it bears homology to some drug-metabolizing cytochrome P450s, it is unknown whether the enzyme is also involved in xenobiotic metabolism. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. Alternate splicing of this gene results in three transcript variants encoding different isoforms.^[5]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000021461 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Domanski TL, Finta C, Halpert JR, Zaphiropoulos PG (Feb 2001). "cDNA cloning and initial characterization of CYP3A43, a novel human cytochrome P450". Mol Pharmacol. 59 (2): 386–92. doi:10.1124/mol.59.2.386. PMID 11160876.
^ Gellner K, Eiselt R, Hustert E, Arnold H, Koch I, Haberl M, Deglmann CJ, Burk O, Buntefuss D, Escher S, Bishop C, Koebe HG, Brinkmann U, Klenk HP, Kleine K, Meyer UA, Wojnowski L (Mar 2001). "Genomic organization of the human CYP3A locus: identification of a new, inducible CYP3A gene". Pharmacogenetics. 11 (2): 111–21. doi:10.1097/00008571-200103000-00002. PMID 11266076.
^ ^a ^b "Entrez Gene: CYP3A43 cytochrome P450, family 3, subfamily A, polypeptide 43".

External links

Human CYP3A43 genome location and CYP3A43 gene details page in the UCSC Genome Browser.

Smith G, Stubbins MJ, Harries LW, Wolf CR (1999). "Molecular genetics of the human cytochrome P450 monooxygenase superfamily". Xenobiotica. 28 (12): 1129–65. doi:10.1080/004982598238868. PMID 9890157.
Finta C, Zaphiropoulos PG (2001). "The human cytochrome P450 3A locus. Gene evolution by capture of downstream exons". Gene. 260 (1–2): 13–23. doi:10.1016/S0378-1119(00)00470-4. PMID 11137287.
Westlind A, Malmebo S, Johansson I, et al. (2001). "Cloning and tissue distribution of a novel human cytochrome p450 of the CYP3A subfamily, CYP3A43". Biochem. Biophys. Res. Commun. 281 (5): 1349–55. doi:10.1006/bbrc.2001.4505. PMID 11243885.
Finta C, Zaphiropoulos PG (2002). "Intergenic mRNA molecules resulting from trans-splicing". J. Biol. Chem. 277 (8): 5882–90. doi:10.1074/jbc.M109175200. PMID 11726664.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7". Nature. 424 (6945): 157–64. Bibcode:2003Natur.424..157H. doi:10.1038/nature01782. PMID 12853948.
Cauffiez C, Lo-Guidice JM, Chevalier D, et al. (2004). "First report of a genetic polymorphism of the cytochrome P450 3A43 (CYP3A43) gene: identification of a loss-of-function variant". Hum. Mutat. 23 (1): 101. doi:10.1002/humu.9211. PMID 14695544. S2CID 9162733.
Hillman RT, Green RE, Brenner SE (2005). "An unappreciated role for RNA surveillance". Genome Biol. 5 (2): R8. doi:10.1186/gb-2004-5-2-r8. PMC 395752. PMID 14759258.
Stone A, Ratnasinghe LD, Emerson GL, et al. (2005). "CYP3A43 Pro(340)Ala polymorphism and prostate cancer risk in African Americans and Caucasians". Cancer Epidemiol. Biomarkers Prev. 14 (5): 1257–61. doi:10.1158/1055-9965.EPI-04-0534. PMID 15894682.
Thompson EE, Kuttab-Boulos H, Yang L, et al. (2006). "Sequence diversity and haplotype structure at the human CYP3A cluster". Pharmacogenomics J. 6 (2): 105–14. doi:10.1038/sj.tpj.6500347. PMID 16314882.
Shchepotina EG, Nikishina MV, Vavilin VA, Lyakhovich VV (2006). "Analysis of restriction fragment length polymorphism of cytochrome P450 3A43 gene and evaluation of the incidence of CYP3A43*1B allele in europeoid residents of West Siberia". Bull. Exp. Biol. Med. 140 (6): 726–8. doi:10.1007/s10517-006-0067-6. PMID 16848237. S2CID 11922749.