CYP4X1

Protein-coding gene in the species Homo sapiens

CYP4X1

Identifiers

Aliases

CYP4X1, CYPIVX1, cytochrome P450 family 4 subfamily X member 1

External IDs

OMIM: 614999 MGI: 1932403 HomoloGene: 75853 GeneCards: CYP4X1

Gene location (Human)

Chr.	Chromosome 1 (human)^[1]

Band	1p33\|1	Start	47,023,669 bp^[1]
Band	1p33\|1	End	47,050,751 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 4 (mouse)^[2]

Band	4\|4 D1	Start	114,963,520 bp^[2]
Band	4\|4 D1	End	114,991,478 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

palpebral conjunctiva

trachea

bronchial epithelial cell

Brodmann area 23

urethra

endothelial cell

right coronary artery

minor salivary glands

ascending aorta

trigeminal ganglion

Top expressed in

facial motor nucleus

substantia nigra

trigeminal ganglion

piriform cortex

dorsomedial hypothalamic nucleus

medial dorsal nucleus

anterior horn of spinal cord

medial geniculate nucleus

temporal lobe

cingulate gyrus

More reference expression data

BioGPS

n/a

Orthologs

Species

Human

Mouse

Entrez


260293


81906

Ensembl


ENSG00000186377


ENSMUSG00000047155

UniProt


Q8N118


Q6A152

RefSeq (mRNA)


NM_178033 NM_001320289 NM_001320290


NM_001003947

RefSeq (protein)


NP_001307218 NP_001307219 NP_828847


NP_001003947

Location (UCSC)

Chr 1: 47.02 – 47.05 Mb

Chr 4: 114.96 – 114.99 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

CYP4X1 (cytochrome P450, family 4, subfamily X, polypeptide 1) is a protein which in humans is encoded by the CYP4X1 gene.^[5]

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The expression pattern of a similar rat protein suggests that this protein may be involved in neurovascular function in the brain.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000186377 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000047155 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Bylund J; Zhang C; Harder DR (August 2002). "Identification of a novel cytochrome P450, CYP4X1, with unique localization specific to the brain". Biochem. Biophys. Res. Commun. 296 (3): 677–84. doi:10.1016/S0006-291X(02)00918-X. PMID 12176035.
^ This article incorporates public domain material from "Entrez Gene: CYP4X1". Reference Sequence collection. National Center for Biotechnology Information.

Clark HF, Gurney AL, Abaya E, et al. (2003). "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
Savas U, Hsu MH, Griffin KJ, et al. (2005). "Conditional regulation of the human CYP4X1 and CYP4Z1 genes". Arch. Biochem. Biophys. 436 (2): 377–85. doi:10.1016/j.abb.2005.02.022. PMID 15797250.
Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Nelson DR, Zeldin DC, Hoffman SM, et al. (2004). "Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants". Pharmacogenetics. 14 (1): 1–18. doi:10.1097/00008571-200401000-00001. PMID 15128046.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.