Calcium-binding mitochondrial carrier protein SCaMC-1

Protein found in humans
SLC25A24
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

4N5X, 4ZCU, 4ZCV

Identifiers
AliasesSLC25A24, APC1, SCAMC-1, solute carrier family 25 member 24, SCAMC1
External IDsOMIM: 608744; MGI: 1917160; HomoloGene: 92693; GeneCards: SLC25A24; OMA:SLC25A24 - orthologs
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for SLC25A24
Genomic location for SLC25A24
Band1p13.3Start108,134,043 bp[1]
End108,200,849 bp[1]
Gene location (Mouse)
Chromosome 3 (mouse)
Chr.Chromosome 3 (mouse)[2]
Chromosome 3 (mouse)
Genomic location for SLC25A24
Genomic location for SLC25A24
Band3|3 F3Start109,030,465 bp[2]
End109,075,773 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • rectum

  • duodenum

  • islet of Langerhans

  • monocyte

  • Achilles tendon

  • endometrium

  • mucosa of transverse colon

  • smooth muscle tissue

  • placenta

  • gallbladder
Top expressed in
  • left colon

  • transitional epithelium of urinary bladder

  • endothelial cell of lymphatic vessel

  • stroma of bone marrow

  • cumulus cell

  • conjunctival fornix

  • belly cord

  • ileum

  • human fetus

  • endocardial cushion
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • calcium ion binding
  • ATP transmembrane transporter activity
  • metal ion binding
  • ADP transmembrane transporter activity
  • transmembrane transporter activity
Cellular component
  • integral component of membrane
  • membrane
  • mitochondrion
  • mitochondrial inner membrane
Biological process
  • regulation of cell death
  • cellular response to calcium ion
  • cellular response to oxidative stress
  • mitochondrial transport
  • transmembrane transport
  • ATP transport
  • ADP transport
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

29957

229731

Ensembl

ENSG00000085491
ENSG00000284468

ENSMUSG00000040322

UniProt

Q6NUK1

Q8BMD8

RefSeq (mRNA)

NM_013386
NM_213651

NM_172685

RefSeq (protein)

NP_037518
NP_998816

NP_766273

Location (UCSC)Chr 1: 108.13 – 108.2 MbChr 3: 109.03 – 109.08 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Calcium-binding mitochondrial carrier protein SCaMC-1 is a protein that in humans is encoded by the SLC25A24 gene.[5]

Function

This gene encodes a carrier protein that transports ATP-Mg exchanging it for phosphate. Multiple transcript variants encoding different isoforms have been found for this gene.

References

  1. ^ a b c ENSG00000284468 GRCh38: Ensembl release 89: ENSG00000085491, ENSG00000284468 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000040322 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: Solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 24".

Further reading

  • Fiermonte G, De Leonardis F, Todisco S, Palmieri L, Lasorsa FM, Palmieri F (July 2004). "Identification of the mitochondrial ATP-Mg/Pi transporter. Bacterial expression, reconstitution, functional characterization, and tissue distribution" (PDF). The Journal of Biological Chemistry. 279 (29): 30722–30. doi:10.1074/jbc.M400445200. PMID 15123600.
  • del Arco A, Satrústegui J (June 2004). "Identification of a novel human subfamily of mitochondrial carriers with calcium-binding domains". The Journal of Biological Chemistry. 279 (23): 24701–13. doi:10.1074/jbc.M401417200. PMID 15054102.
  • Traba J, Del Arco A, Duchen MR, Szabadkai G, Satrústegui J (April 2012). "SCaMC-1 promotes cancer cell survival by desensitizing mitochondrial permeability transition via ATP/ADP-mediated matrix Ca(2+) buffering". Cell Death and Differentiation. 19 (4): 650–60. doi:10.1038/cdd.2011.139. PMC 3307981. PMID 22015608.
  • Palmieri F (2013). "The mitochondrial transporter family SLC25: identification, properties and physiopathology". Molecular Aspects of Medicine. 34 (2–3): 465–84. doi:10.1016/j.mam.2012.05.005. PMID 23266187.
  • Jia L, Young MF, Powell J, Yang L, Ho NC, Hotchkiss R, Robey PG, Francomano CA (January 2002). "Gene expression profile of human bone marrow stromal cells: high-throughput expressed sequence tag sequencing analysis". Genomics. 79 (1): 7–17. doi:10.1006/geno.2001.6683. PMID 11827452.
  • Overview of all the structural information available in the PDB for UniProt: Q6NUK1 (Human Calcium-binding mitochondrial carrier protein SCaMC-1) at the PDBe-KB.


This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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