Carlos Chagas Filho

Carlos Chagas Filho (September 10, 1910 – February 16, 2000) was a Brazilian physician, biologist and scientist active in the field of neuroscience. He was internationally renowned for his investigations on the neural mechanisms underlying the phenomenon of electrogenesis by the electroplaques of electric fishes. He was also an important scientific leader, being one of the founders of the Biophysics Institute of the Federal University of Rio de Janeiro and was also a president for 16 years of the Vatican's Pontifical Academy of Sciences, and president of the Brazilian Academy of Sciences (1965–1967).

Life

He was the second son of Carlos Chagas (1879–1934), an eminent scientist who is credited with the discovery of Chagas disease. His oldest brother was Evandro Chagas (1905–1940), also a physician and scientist specialized, like his father, in tropical medicine.

He studied medicine from 1926 to 1931 at the Faculdade de Medicina da Universidade do Brasil (presently the Federal University of Rio de Janeiro). While a student he worked at Manguinhos, where the Instituto Oswaldo Cruz was founded by the physician Oswaldo Cruz (1872–1917) and where his father worked, as well as at a hospital in Lassance, state of Minas Gerais, where his father had discovered Chagas disease. After graduation, he went to become a director of this hospital during 1932. But what he really liked to do was biomedical research, following the example of his father and colleagues, so in the next years he worked with several leaders in the field of physiology, such as Miguel Osório de Almeida (1890–1952) and José Carneiro Felippe. One year after graduation, he accepted a teaching post as assistant professor at the Medical School, in the chair of Biological Physics. With the death of its incumbent, Lafayette Rodrigues Pereira, he became its chairman and full professor.

Feeling the need to specialize further in neurophysiology, Filho travelled to France, where he worked with René Wurmser and Alfred Fessard, in Paris, and to England, where he worked with A.V. Hill (1886–1977). Returning to Brazil, he established a Laboratory of Biophysics at the Medical School and assembled a group of students and researchers. In 1945 he achieved the elevation of the Laboratory to the Biophysics Institute, which in a short time became one of the most important and excellent research centers in Brazil. He was its director for a long time, as well as the dean of the Medical School. The Institute presently bears his name. Carlos Chagas Filho retired in 1980, but continued to work steadfastly almost until his death, at 89 years of age.

Work

Filho's main scientific contribution was centered on the study of the electroplaques of the "poraquê" or electric eel (Electrophorus electricus), actually a fresh water electric fish native to the Amazon. With his group, he made important and original advances in the elucidation of its anatomy and electrophysiology, cytochemistry, as well as its nervous control. He discovered the brain command structures which control electrical discharges. He discovered also that the electroplaques has two kinds of excitability, one which is direct, and another which is reflex via the nervous pathways. He studied also the effects of curare on the electroplaques, which are modified striated muscles and thus have synaptic transmission based on acetylcholine (curare is an antagonist of this neurotransmitter). Filho also isolated the ACh membrane receptor.

As an educator, Filho left an important influence on biomedical research in Brazil, through his many scientific disciples and colleagues at the Biophysics Institute, such as Aristides Azevedo Pacheco Leão. It was during the initial years of the Institute, also, that Rita Levi-Montalcini (1909-), then a young researcher of Jewish descent who had to escape fascism, worked towards her important discoveries on neurotrophic factors, supported by Carlos Chagas Filho. She later received the Nobel Prize of Physiology and Medicine.

He published several books, including an autobiography, a biographical memoir about his father and more than 100 scientific papers.

Scientific leadership and honours

Dr. Chagas Filho played a significant role as international leader and representative of Brazilian science abroad. He was a Brazilian delegate and ambassador (1966) to UNESCO in Paris, and member of the Research Council of the Pan American Health Organization (PAHO), in Washington, DC. At the United Nations he was president of the Special Committee for the Application of Science and Technology to Development. Together with Nobel Prize winner, physicist Abdus Salam (1926–1996), he founded the International Federation of Institutes for Advanced Sciences (IFIAS).

In 1972, he was appointed by Pope Paul VI to the presidency of the Pontifical Academy of Sciences, which he occupied until 1989. During his tenure, he was distinguished with the historical task of rehabilitating Galileo Galilei by the Roman Catholic Church and with coordinating a study of the historical and scientific validity of the Turin shroud. He was deeply religious and sought to reconcile science and religion as best as possible. Thus, he led the Academy of Sciences through a number of important meetings and publications, examining controversial issues such as the brain and conscience, and attracting great scientific personalities to the Academy, including a number of Nobel awardees.

In Brazil he was a member, vice-president and president of the Brazilian Academy of Sciences (1941–2000) and member of the Brazilian Academy of Letters (1974–2000), a member of the National Research Council and one of the founders and member of the Brazilian Society for the Advancement of Science.

Carlos Chagas Filho was awarded with 16 titles of Honoris Causa Doctor in many national and foreign universities, and 19 decorations, including that of Légion d'Honneur (1979) and the Brazilian Order of Scientific Merit. He was a member of the French Académie des Sciences and Académie Nationale de Médecine, Academia das Ciências de Lisboa, American Academy of Arts and Sciences, American Philosophical Academy, Royal Academy of Belgium, Romanian Academy of Sciences and the International Academy of the History of Science.

Among his many scientific awards, he received the Moinho Santista Science Prize (1960); the Prêmio Álvaro Alberto para a Ciência e Tecnologia (1988); and the Prix mondial Cino Del Duca, by the Fondation Simone et Cino Del Duca, France (1989).

Bibliography

• Chagas Filho, C. Carlos Chagas, Meu Pai. Rio de Janeiro, Casa de Oswaldo Cruz/Fiocruz, 1993.
• E Gomes-Quintana, RD Machado, C Chagas Filho. Cholinergic membranes from normal and denervated electric organ of Electrophorus electricus (L.). IRCS Med. Sci Biochem, 1980.
• CS Mermelstein, V Moura Neto, C Chagas Filho . Desmin expression in the electric organs of Electrophorus electricus (L.). J Cell Biochem, 1988.
• H Meyer, G Oliveira Castro, C Chagas Filho. Quelques aspects de l’histogenese et de l’ontogenese des organes électriques chez l’ Electrophorus electricus… CR Acad Sci Paris, 1971.
• C Chagas Filho, E Penna-Franca, A Hassón-Voloch. Studies of the mechanism of curarization. An Acad Bras Cien, 1957.

External links

• Almeida DF. Carlos Chagas Filho, Scientist and Citizen. An Acad Bras Cienc. 2000 Sep;72(3):299-300. Full text in English
• Carlos Chagas Filho. Brazilian Academy of Sciences biography (In English)
• Carlos Chagas Filho. Notable Brazilians. Instituto Brasileiro de Informação Científica e Tecnológica. (In Portuguese)
• Carlos Chagas Filho. Brazilian Academy of Letters biography (in Portuguese)
• Pinto-Dias, JC. Carlos Chagas Filho e a doença de Chagas. Alguns traços à luz de confidências e inconfidências . Rev. Soc. Bras. Med. Trop. 2000; 33(3). Eulogy (in Portuguese). Full text
• Biography and interviews. Instituto Oswaldo Cruz. (In Portuguese)
• Instituto de Biofísica Carlos Chagas Filho website.
• Darcy Fontoura de Almeida, «Carlos Chagas Filho», Biographical Memoirs - Proceedings of the American Philosophical Society (vol. 147, no. 1, 2003, pp. 77–82)

Preceded by Marques Rebelo

Brazilian Academy of Letters - Occupant of the 9th chair 1974 — 2000

Succeeded by Alberto da Costa e Silva

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Patrons and members of the Brazilian Academy of Letters

Chairs
1 to 10

1 (Adelino Fontoura): Luís Murat ► Afonso d'Escragnolle Taunay ► Ivan Monteiro de Barros Lins ► Bernardo Élis ► Evandro Lins e Silva ► Ana Maria Machado
2 (Álvares de Azevedo): Coelho Neto ► João Neves da Fontoura ► João Guimarães Rosa ► Mário Palmério ► Tarcísio Padilha ► Eduardo Giannetti da Fonseca
3 (Artur de Oliveira): Filinto de Almeida ► Roberto Simonsen ► Aníbal Freire da Fonseca ► Herberto Sales ► Carlos Heitor Cony ► Joaquim Falcão
4 (Basílio da Gama): Aluísio Azevedo ► Alcides Maia ► Viana Moog ► Carlos Nejar
5 (Bernardo Guimarães): Raimundo Correia ► Oswaldo Cruz ► Aloísio de Castro ► Cândido Mota Filho ► Rachel de Queiroz ► José Murilo de Carvalho ► Ailton Krenak
6 (Casimiro de Abreu): Teixeira de Melo ► Artur Jaceguai ► Goulart de Andrade ► Barbosa Lima Sobrinho ► Raimundo Faoro ► Cícero Sandroni
7 (Castro Alves): Valentim Magalhães ► Euclides da Cunha ► Afrânio Peixoto ► Afonso Pena Júnior ► Hermes Lima ► Pontes de Miranda ► Diná Silveira de Queirós ► Sérgio Correia da Costa ► Nelson Pereira dos Santos ► Cacá Diegues
8 (Cláudio Manuel da Costa): Alberto de Oliveira ► Oliveira Viana ► Austregésilo de Athayde ► Antônio Calado ► Antônio Olinto ► Cleonice Berardinelli ► Ricardo Cavaliere
9 (Gonçalves de Magalhães): Carlos Magalhães de Azeredo ► Marques Rebelo ► Carlos Chagas Filho ► Alberto da Costa e Silva ► Vacant
10 (Evaristo da Veiga): Rui Barbosa ► Laudelino Freire ► Osvaldo Orico ► Orígenes Lessa ► Lêdo Ivo ► Rosiska Darcy de Oliveira

Chairs
11 to 20

11 (Fagundes Varela): Lúcio de Mendonça ► Pedro Augusto Carneiro Lessa ► Eduardo Ramos ► João Luís Alves ► Adelmar Tavares ► Deolindo Couto ► Darcy Ribeiro ► Celso Furtado ► Hélio Jaguaribe ► Ignácio de Loyola Brandão
12 (França Júnior): Urbano Duarte de Oliveira ► Antônio Augusto de Lima ► Vítor Viana ► José Carlos de Macedo Soares ► Abgar Renault ► Lucas Moreira Neves ► Alfredo Bosi ► Paulo Niemeyer Filho
13 (Francisco Otaviano): Alfredo d'Escragnolle Taunay ► Francisco de Castro ► Martins Júnior ► Sousa Bandeira ► Hélio Lobo ► Augusto Meyer ► Francisco de Assis Barbosa ► Sérgio Paulo Rouanet ► Ruy Castro
14 (Franklin Távora): Clóvis Beviláqua ► Antônio Carneiro Leão ► Fernando de Azevedo ► Miguel Reale ► Celso Lafer
15 (Gonçalves Dias): Olavo Bilac ► Amadeu Amaral ► Guilherme de Almeida ► Odilo Costa Filho ► Marcos Barbosa ► Fernando Bastos de Ávila ► Marco Lucchesi
16 (Gregório de Matos): Araripe Júnior ► Félix Pacheco ► Pedro Calmon ► Lygia Fagundes Telles ► Jorge Caldeira
17 (Hipólito da Costa): Sílvio Romero ► Osório Duque-Estrada ► Edgar Roquette-Pinto ► Álvaro Lins ► Antônio Houaiss ► Affonso Arinos de Mello Franco ► Fernanda Montenegro
18 (João Francisco Lisboa): José Veríssimo ► Barão Homem de Melo ► Alberto Faria ► Luís Carlos ► Pereira da Silva ► Peregrino Júnior ► Arnaldo Niskier
19 (Joaquim Caetano): Alcindo Guanabara ► Silvério Gomes Pimenta ► Gustavo Barroso ► Silva Melo ► Américo Jacobina Lacombe ► Marcos Almir Madeira ► Antônio Carlos Secchin
20 (Joaquim Manuel de Macedo): Salvador de Mendonça ► Emílio de Meneses ► Humberto de Campos ► Múcio Leão ► Aurélio de Lira Tavares ► Murilo Melo Filho ► Gilberto Gil

Chairs
21 to 30

21 (Joaquim Serra): José do Patrocínio ► Mário de Alencar ► Olegário Mariano ► Álvaro Moreira ► Adonias Filho ► Dias Gomes ► Roberto Campos ► Paulo Coelho
22 (José Bonifácio the Younger): Medeiros e Albuquerque ► Miguel Osório de Almeida ► Luís Viana Filho ► Ivo Pitanguy ► João Almino
23 (José de Alencar): Machado de Assis ► Lafayette Rodrigues Pereira ► Alfredo Pujol ► Otávio Mangabeira ► Jorge Amado ► Zélia Gattai ► Luiz Paulo Horta ► Antônio Torres
24 (Júlio Ribeiro): Garcia Redondo ► Luís Guimarães Filho ► Manuel Bandeira ► Cyro dos Anjos ► Sábato Magaldi ► Geraldo Carneiro
25 (Junqueira Freire): Franklin Dória ► Artur Orlando da Silva ► Ataulfo de Paiva ► José Lins do Rego ► Afonso Arinos de Melo Franco ► Alberto Venancio Filho
26 (Laurindo Rabelo): Guimarães Passos ► João do Rio ► Constâncio Alves ► Ribeiro Couto ► Gilberto Amado ► Mauro Mota ► Marcos Vilaça
27 (Antônio Peregrino Maciel Monteiro): Joaquim Nabuco ► Dantas Barreto ► Gregório da Fonseca ► Levi Carneiro ► Otávio de Faria ► Eduardo Portella ► Antonio Cícero
28 (Manuel Antônio de Almeida): Inglês de Sousa ► Xavier Marques ► Menotti Del Picchia ► Oscar Dias Correia ► Domício Proença Filho
29 (Martins Pena): Artur Azevedo ► Vicente de Carvalho ► Cláudio de Sousa ► Josué Montello ► José Mindlin ► Geraldo Holanda Cavalcanti
30 (Pardal Mallet): Pedro Rabelo ► Heráclito Graça ► Antônio Austregésilo ► Aurélio Buarque de Holanda Ferreira ► Nélida Piñon ► Heloísa Teixeira

Chairs
31 to 40

31 (Pedro Luís Pereira de Sousa): Luís Caetano Pereira Guimarães Júnior ► João Batista Ribeiro de Andrade Fernandes ► Paulo Setúbal ► Cassiano Ricardo ► José Cândido de Carvalho ► Geraldo França de Lima ► Moacyr Scliar ► Merval Pereira
32 (Manuel de Araújo Porto-Alegre): Carlos de Laet ► Ramiz Galvão ► Viriato Correia ► Joracy Camargo ► Genolino Amado ► Ariano Suassuna ► Zuenir Ventura
33 (Raul Pompeia): Domício da Gama ► Fernando Magalhães ► Luís Edmundo ► Afrânio Coutinho ► Evanildo Bechara
34 (Sousa Caldas): João Manuel Pereira da Silva ► José Maria da Silva Paranhos Jr. ► Lauro Müller ► Aquino Correia ► Magalhães Júnior ► Carlos Castelo Branco ► João Ubaldo Ribeiro ► Zuenir Ventura ► Evaldo Cabral de Mello
35 (Tavares Bastos): Rodrigo Otávio ► Rodrigo Otávio Filho ► José Honório Rodrigues ► Celso Cunha ► Cândido Mendes de Almeida ► Godofredo de Oliveira Neto
36 (Teófilo Dias): Afonso Celso ► Clementino Fraga ► Paulo Carneiro ► José Guilherme Merquior ► João de Scantimburgo ► Fernando Henrique Cardoso
37 (Tomás António Gonzaga): José Júlio da Silva Ramos ► José de Alcântara Machado ► Getúlio Vargas ► Assis Chateaubriand ► João Cabral de Melo Neto ► Ivan Junqueira ► Ferreira Gullar ► Arno Wehling
38 (Tobias Barreto): Graça Aranha ► Alberto Santos-Dumont ► Celso Vieira ► Maurício Campos de Medeiros ► José Américo de Almeida ► José Sarney
39 (Francisco Adolfo de Varnhagen): Manuel de Oliveira Lima ► Alberto de Faria ► Rocha Pombo ► Rodolfo Garcia ► Elmano Cardim ► Otto Lara Resende ► Roberto Marinho ► Marco Maciel ► José Paulo Cavalcanti Filho
40 (José Maria da Silva Paranhos Sr.): Eduardo Prado ► Afonso Arinos ► Miguel Couto ► Alceu Amoroso Lima ► Evaristo de Moraes Filho ► Edmar Bacha