Cilostamide

Cilostamide
Names
Preferred IUPAC name
N-Cyclohexyl-N-methyl-4-[(2-oxo-1,2-dihydroquinolin-6-yl)oxy]butanamide
Identifiers
CAS Number
  • 68550-75-4 checkY
3D model (JSmol)
  • Interactive image
ChEMBL
  • ChEMBL34431
ChemSpider
  • 2651
IUPHAR/BPS
  • 5167
PubChem CID
  • 2753
UNII
  • 45S5605Q18 checkY
CompTox Dashboard (EPA)
  • DTXSID3045140 Edit this at Wikidata
InChI
  • InChI=1S/C20H26N2O3/c1-22(16-6-3-2-4-7-16)20(24)8-5-13-25-17-10-11-18-15(14-17)9-12-19(23)21-18/h9-12,14,16H,2-8,13H2,1H3,(H,21,23)
    Key: UIAYVIIHMORPSJ-UHFFFAOYSA-N
  • CN(C1CCCCC1)C(=O)CCCOC2=CC3=C(C=C2)NC(=O)C=C3
Properties
Chemical formula
 C20H26N2O3
Molar mass 342.439 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references
Chemical compound

Cilostamide is a PDE3 inhibitor.[1]

References

  1. ^ De Jonge, HR; Tilly, BC; Hogema, BM; Pfau, DJ; Kelley, CA; Kelley, MH; Melita, AM; Morris, MT; Viola, RM; Forrest, JN (2013). "CGMP Inhibition of Type 3 Phosphodiesterase is the Major Mechanism by which C-type Natriuretic Peptide Activates CFTR in the Shark Rectal Gland". American Journal of Physiology. Cell Physiology. 306 (4): C343–C353. doi:10.1152/ajpcell.00326.2013. PMC 3919979. PMID 24259420.
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Phosphodiesterase inhibitors
PDE1
  • MMPX
  • SCH-51866
  • Vinpocetine
PDE2
PDE3PDE4
PDE5PDE7PDE9PDE10
PDE11
BC11-38
Non-selectiveUnsorted
See also: Receptor/signaling modulators


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