Councilman body

In pathology, a Councilman body, also known as a Councilman hyaline body or apoptotic body, is an eosinophilic globule of apoptotic hepatocyte cell fragments. Ultimately, the fragments are taken up by macrophages or adjacent parenchymal cells.^[1] They are found in the liver of individuals suffering from acute viral hepatitis, yellow fever, and other viral syndromes.^[2]

Associated conditions

Councilman bodies were first identified in yellow fever, which characteristically shows a midzonal hepatic necrosis on biopsy. Similar inclusions are observed in other viral hemorrhagic fevers and all of the viral hepatitides. Liver biopsy of acute viral hepatitis shows panlobular lymphocytic infiltrates with ballooning hepatocytes.

Eponym

Councilman bodies are named after American pathologist William Thomas Councilman (1854–1933), who discovered them.

References

^ Ivan Damjanov, MD, PhD: Pathology for the Health Professions, 4th ed, St. Louis, Saunders Elsevier, 2012, p 19, Fig. 1-26.)
^ "Hepatic Pathology".

Signs and symptoms relating to the human digestive system or abdomen

Gastrointestinal
tract

Accessory

liver: Councilman body
Mallory body

biliary: Boas' sign
Courvoisier's law
Charcot's cholangitis triad/Reynolds' pentad
cholecystitis (Murphy's sign
Lépine's sign
Mirizzi's syndrome)
Nardi test

Defecation

Abdomen

Pain	Abdominal pain Acute abdomen Colic Baby colic Abdominal guarding Blumberg's sign
Distension	Abdominal distension Bloating Ascites Tympany Shifting dullness Fluid wave test
Masses	Abdominal mass Hepatosplenomegaly Hepatomegaly Splenomegaly
Other	Jaundice Mallet-Guy's sign Puddle sign Ballance's sign Aortic insufficiency Castell's sign Kehr's sign Cullen's sign Grey Turner's sign

Hernia

Other

v t e Blood tests for infectious disease
Bacterial infection	syphilis Venereal Disease Research Laboratory test rapid plasma reagin Wassermann test Fluorescent treponemal antibody absorption test Abelin reaction Rickettsia Weil–Felix test Helicobacter HelicoCARE direct Streptococcus Anti-streptolysin O
Viral infection	HIV testing Branched DNA assay mChip Epstein–Barr virus Heterophile antibody test Dengue fever NS1 antigen test measles Warthin–Finkeldey cell Inclusion bodies Downie bodies B type inclusion Orthopoxvirus inclusion bodies rabies Negri bodies Cowdry bodies yellow fever Councilman body Tzanck test
Protozoan infection	toxoplasmosis Sabin–Feldman dye test malaria Diagnosis of malaria Schüffner's dots
Bloodstream infections	Blood culture Viremia Fungemia Parasitemia Algaemia
General	C-reactive protein Procalcitonin