DBX1

DBX1
Identifiers
Aliases	DBX1, developing brain homeobox 1, HLX1
External IDs	MGI: 94867 HomoloGene: 19002 GeneCards: DBX1
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11p15.1 Start 20,156,155 bp[1] End 20,160,475 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7 B4|7 31.44 cM Start 49,281,247 bp[2] End 49,286,597 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in pituitary gland Top expressed in tongue pineal gland condyle dermis extraocular muscle thoracic diaphragm ureter medial ganglionic eminence limb spinal cord More reference expression data BioGPS n/a
Gene ontology Molecular function sequence-specific DNA binding DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component nucleus Biological process regulation of transcription by RNA polymerase II multicellular organism development ventral spinal cord interneuron specification regulation of transcription, DNA-templated cell differentiation in spinal cord Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 120237 13172 Ensembl ENSG00000109851 ENSMUSG00000030507 UniProt A6NMT0 P52950 RefSeq (mRNA) NM_001029865 NM_001005232 RefSeq (protein) NP_001025036 NP_001005232 Location (UCSC) Chr 11: 20.16 – 20.16 Mb Chr 7: 49.28 – 49.29 Mb PubMed search [3] [4]
Wikidata
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Homeobox protein DBX1, also known as developing brain homeobox protein 1, is a protein that in humans is encoded by the DBX1 gene. The DBX1 gene is a transcription factor gene that is pivotal in interneuron differentiation in the ventral spinal cord.

The spinal interneurons V0 and V1 are derived from progenitor domains that are differentiated by the expression of homeodomain proteins DBX1 and DBX2. DBX1 is spatially restricted and has a critical role in establishing the distinction of V0 and V1 neuronal fate. In DBX1 mutant mice, neural progenitors fail to generate V0 interneurons and instead gave rise to interneurons expressing V1 characteristics, such as their transcription factor profile, neurotransmitter phenotype, migratory pattern, and aspects of their axonal trajectory, suggesting that this single homeodomain transcription factor coordinates many of the differentiated properties of one class of interneurons generated in the ventral spinal cord.

V0 and V1 interneurons are thought to be critical in the role of rhythmic breathing, after using a neonatal mouse model. Destruction of these DBX1 neurons in the pre-Botzinger complex showed an impaired respiratory rhythm as well as a decreased magnitude of motor output activity.^[5][6]

References

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