DMeOB

Chemical compound
DMeOB
Space-filling model of the DMeOB
Identifiers
  • 1-(3-methoxyphenyl)-N-[(3-methoxyphenyl)methylideneamino]methanimine
CAS Number
  • 40252-74-2 checkY
PubChem CID
  • 6891506
ChemSpider
  • 5277863 ☒N
CompTox Dashboard (EPA)
  • DTXSID10425967 Edit this at Wikidata
ECHA InfoCard100.164.778 Edit this at Wikidata
Chemical and physical data
FormulaC16H16N2O2
Molar mass268.316 g·mol−1
3D model (JSmol)
  • Interactive image
  • COc2cc(ccc2)C=NN=Cc1cccc(OC)c1
InChI
  • InChI=1S/C16H16N2O2/c1-19-15-7-3-5-13(9-15)11-17-18-12-14-6-4-8-16(10-14)20-2/h3-12H,1-2H3/b17-11+,18-12+ ☒N
  • Key:FBNPHFBYHYNMHC-JYFOCSDGSA-N ☒N
 ☒NcheckY (what is this?)  (verify)

DMeOB is a drug used in scientific research which acts as a negative allosteric modulator of the metabotropic glutamate receptor subtype mGluR5.[1]

References

  1. ^ O'Brien JA, Lemaire W, Chen TB, Chang RS, Jacobson MA, Ha SN, Lindsley CW, Schaffhauser HJ, Sur C, Pettibone DJ, Conn PJ, Williams DL (September 2003). "A family of highly selective allosteric modulators of the metabotropic glutamate receptor subtype 5". Molecular Pharmacology. 64 (3): 731–40. doi:10.1124/mol.64.3.731. PMID 12920211.
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Metabotropic glutamate receptor modulators
Group I
mGluR1Tooltip Metabotropic glutamate receptor 1
mGluR5Tooltip Metabotropic glutamate receptor 5
Group II
mGluR2Tooltip Metabotropic glutamate receptor 2
mGluR3Tooltip Metabotropic glutamate receptor 3
Group III
mGluR4Tooltip Metabotropic glutamate receptor 4
  • Antagonists: CPPG
  • MAP4
  • MPPG
  • MSOP
  • MTPG
  • UBP-1112
mGluR6Tooltip Metabotropic glutamate receptor 6
  • Antagonists: CPPG
  • MAP4
  • MPPG
  • MSOP
  • MTPG
  • UBP-1112
mGluR7Tooltip Metabotropic glutamate receptor 7
  • Antagonists: CPPG
  • MAP4
  • MMPIP
  • MPPG
  • MSOP
  • MTPG
  • UBP-1112
  • XAP044; Negative allosteric modulators: ADX71743
mGluR8Tooltip Metabotropic glutamate receptor 8
  • Antagonists: CPPG
  • MAP4
  • MPPG
  • MSOP
  • MTPG
  • UBP-1112
See also: Receptor/signaling modulators • Ionotropic glutamate receptor modulators • Glutamate metabolism/transport modulators


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